Bacterial Meningitis Research Paper

Cause
Bacterial meningitis can become serious even causing death in as little as a couple of hours. Those who are affected by this disease can recover for it. However, those who are unfortunate may have permanent disabilities including: hearing loss, brain damage, learning disabilities, etc. caused by the infection. There are a number of bacteria’s that result in meningitis such as: streptococcus pneumoniae, group B streptococcus, Neisseria meningitides, Haemophilus influenza, and listeria monocytogenes (CDC, 2017). The organisms responsible in causing bacterial meningitis colonizes the nasopharynx from there they enter into the blood stream entering the subarachnoid space passing by endothelial cells, traveling across the porous choroid plexus
The toxins from the bacterial can result in neuronal apoptosis, cell wall lipopolysaccharide, resulting in clotting leading to disseminated intravascular coagulation. Severe outcomes from the bacteria can be caused from an inflammation response. The cells that are innate and a part of the immune system of the brain found in the choroid plexus/BBB and ependymal identifies the bacteria secreting chemokines, complement, and cytokines attracting circulating granulocytes into the CSF. Macrophages and granulocytes are known to be strong lysosomal enzymes/free radicals that kill bacteria, but with a short life span. As they undergo lyse these components spill killing everything in their path. However, accumulation of neutrophils can lead to nerve, blood vessel, and brain damage resulting from partially or direct contact of the bacteria and partially by an antibacterial inflammatory response. The brain very intricate with the ability in regulating inflammation, however, an unbalanced defense reaction can result in severe injury. Bacterial meningitis can be dangerous and complicated increasing the chances of intracranial pressure from cerebral edema can include a combination of or all such as: vasogenic resulting from an increase of vascular permeability, cerebral hypoxia/cytotoxic, interstitial, and an increase of CSF. An increase of intracranial pressure could lead to a decrease of cerebral perfusion, neuronal
Signs and symptoms found in adults consisting of: stiff neck, fever, headache, difficulty sleeping, trouble waking from sleeping, vomiting, nausea, lack of appetite, and lack of energy. Those with viral meningitis their body is able to fight if off within 7-10 days. However, those infected with bacterial is typically serious and can lead to dangerous complications including: hearing loss, learning disabilities, and brain damage. The bacterial responsible for meningitis can also be associated with other diseases such as sepsis (a complications resulting by the body becoming overwhelmed and life threatening response infection that can cause damage to the tissue, failure of an organ, and even death) (CDC,