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typhoid fever

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typhoid fever
TYPHOID
FEVER
BY: CATHERINE E. JOAQUIN

REPORT CONTENT


INTRODUCTION



SIGNS AND SYMPTOMS



PATHOGENS AND VIRULENCE FACTORS



PATHOGENESIS/TRANSMISSION



EPIDEMIOLOGY



DIAGNOSIS, TREATMENT AND PREVENTION

INTRODUCTION

What are Food & Waterborne
Diseases?
 Diseases

that are supported, carried or transmitted by food & water.

 Examples

are: Cholera, Hepatitis A,
Amoebic Dysentery, & Typhoid Fever

INTRODUCTION

What is a Typhoid Fever?
 It

is an acute bacterial infection characterized by fever, headache and abdominal discomfort.

 Also

known as ENTERIC FEVER

PATHOGENS & VIRULENCE FACTORS

What causes Typhoid Fever?
 Typhoid

Fever is caused by the bacterium Salmonella typhi from the family Enterobacteriacea.

 Salmonella

typhi is a gram-negative bacteria that is motile due to its peritrichous flagella

 The

bacteria grows best at 37°C.

Color pink therefore Gramnegative

With peritrichous flagella PATHOGENS & VIRULENCE FACTORS

can also be caused by Salmonella paratyphi, a related bacterium that usually causes a less severe illness known as Paratyphoid Fever.

 It

PATHOGENESIS

How does the bacteria cause disease? Ingestion of contaminated food or water Salmonella bacteria penetrate the epithelial wall of the small intestine Phagocytosed by macrophages

PATHOGENESIS

How does the bacteria cause disease? S. typhi then alters its structure to resist destruction and allow them to exist within the macrophage Spread via the lymphatics while inside the macrophages

Travels to the reticulo endothelial system and then to the different organs throughout the body

PATHOGENESIS

How does the bacteria cause disease? Goes back to the bloodstream accompanied with development of symptoms

Salmonella bacteria may be passed out through the stool

Cycle continues SIGNS AND

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