To produce a vaccine, the antigen that stimulates the immune response is first generated. Viruses are grown on primary cells, bacteria in bioreactors and recombinant proteins derived from the pathogen are generated in either bacteria, yeast or cell cultures. Secondly, the antigen is released and isolated from the …show more content…
Both epidemiologic and mechanistic research done by the Institute of Medicine suggest that most individuals who experience an adverse reaction to the vaccine have a pre-existing susceptibility which can be due to many reasons- environmental exposure, behaviour, developmental stage or even genetic variants in DNA. Of course, the occurrence of such reactions are low, however, if vaccines are made mandatory, those with the risk of these adverse reactions that include brain damage, auto-immune disorder and seizures in severe cases will be sacrificed. In 2007, it was recorded that there were over 235 million doses of all vaccines distributed in the United States, and there were approximately 350 cases of vaccine-induced anaphylaxis which are life-threatening reactions to the vaccine. Vaccination is contraindicated when a person experiences anaphylaxis following a dose of a vaccine or following any vaccine component. To protect these people from such an experience, vaccines should not be made