Neururoprotective Effect Of Curcumin Nannoparticles: A Case Study
Objective The present study was conducted to evaluate the neuroprotective effect of curcumin nanoparticles (CUR NP) against the neurotoxicity induced by cisplatin (CP) in rat.
Material and methods: Rats were divided into control group that received saline solution; CP-treated rats that received a single i.p. injection of CP (12 mg/kg) and CP-treated rats that received a single i.p injection of CP (12 mg /kg) followed by a daily oral administration of CUR NP (50 mg/kg) for 14 days. At the end of the experiment, the motor activity of rats was evaluated by open field test. The neurochemical and histopathological changes were investigated in the cerebral cortex.
Results A significant decrease in motor activity was observed in CP-treated rats. …show more content…
Curcumin’s neuroprotective effect was investigated in a number of animal models of neurodegenerative diseases including epilepsy [18], Parkinson’s disease [19], depression [20] and Alzheimer’s disease [21]. In addition, several studies have shown that curcumin possesses antitumor, anti-inflammatory and antioxidant effects [22]. Unfortunately, curcumin in its normal form is characterized by low water solubility. This character reduces its bioavailability [23, 24]. The low water solubility of curcumin results in decreased absorption, extensive metabolism, and rapid systemic elimination of serum and tissue levels of curcumin [25, 26]. Therefore, curcumin has a very short retention time in the body [26] and hence, its therapeutic efficacy will be restricted. Wahlstrom and Blennow demonstrated that after oral administration of 1 g/kg of curcumin, more than 75% was excreted in feces and negligible amounts of curcumin were detected in urine [27]. These findings indicate that a limited amount of curcumin could be absorbed to the systemic circulation. Under such conditions, several studies have been carried out to solve the problem of curcumin’s low water solubility to exploit the benefits of curcumin and exaggerate its therapeutic efficacy. One of such strategies is to use curcumin in its nanoparticle form. It has been suggested that nanocurcumin represents a promising therapeutic …show more content…
This was achieved by evaluating the effect of CUR NP on the levels of oxidative stress parameters (lipid peroxidation, nitric oxide and reduced glutathione), caspase-3 and tumor necrosis factor-α and the activities of acetylcholinesterase and Na+, K+-ATPase in the cerebral cortex of CP-treated rats. The present study also extended to investigate the effect of CUR NP on the changes in the motor activity and histological profile of rats treated with
Material and methods: Rats were divided into control group that received saline solution; CP-treated rats that received a single i.p. injection of CP (12 mg/kg) and CP-treated rats that received a single i.p injection of CP (12 mg /kg) followed by a daily oral administration of CUR NP (50 mg/kg) for 14 days. At the end of the experiment, the motor activity of rats was evaluated by open field test. The neurochemical and histopathological changes were investigated in the cerebral cortex.
Results A significant decrease in motor activity was observed in CP-treated rats. …show more content…
Curcumin’s neuroprotective effect was investigated in a number of animal models of neurodegenerative diseases including epilepsy [18], Parkinson’s disease [19], depression [20] and Alzheimer’s disease [21]. In addition, several studies have shown that curcumin possesses antitumor, anti-inflammatory and antioxidant effects [22]. Unfortunately, curcumin in its normal form is characterized by low water solubility. This character reduces its bioavailability [23, 24]. The low water solubility of curcumin results in decreased absorption, extensive metabolism, and rapid systemic elimination of serum and tissue levels of curcumin [25, 26]. Therefore, curcumin has a very short retention time in the body [26] and hence, its therapeutic efficacy will be restricted. Wahlstrom and Blennow demonstrated that after oral administration of 1 g/kg of curcumin, more than 75% was excreted in feces and negligible amounts of curcumin were detected in urine [27]. These findings indicate that a limited amount of curcumin could be absorbed to the systemic circulation. Under such conditions, several studies have been carried out to solve the problem of curcumin’s low water solubility to exploit the benefits of curcumin and exaggerate its therapeutic efficacy. One of such strategies is to use curcumin in its nanoparticle form. It has been suggested that nanocurcumin represents a promising therapeutic …show more content…
This was achieved by evaluating the effect of CUR NP on the levels of oxidative stress parameters (lipid peroxidation, nitric oxide and reduced glutathione), caspase-3 and tumor necrosis factor-α and the activities of acetylcholinesterase and Na+, K+-ATPase in the cerebral cortex of CP-treated rats. The present study also extended to investigate the effect of CUR NP on the changes in the motor activity and histological profile of rats treated with