coagulation

Schematic representation of the different phases of wound repair

The four physiologic processes that interrelate to limit blood loss

Formed elements of the blood various colony-stimulating factors (CSF)
G, granulocyte
M, macrophage

System for Naming Blood-Clotting Factors
I

Fibrinogen

II

Prothrombin

III

Thromboplastin

IV

Calcium

V

Proaccelerin, labile factor, accelerator globulin

VII

Proconvertin, SPCA, stable factor

VIII

Antihemophilic factor (AHF), antihemophilic factor A, antihemophilic globulin (AHG)

IX

Plasma thromboplastic component (PTC), Christmas factor, antihemophilic factor B

X

Stuart–Prower factor

XI

Plasma thromboplastin antecedent (PTA), antihemophilic factor C

XII

Hageman factor, glass factor

XIII

Fibrin-stabilizing factor, Laki–Lorand factor

HMW-K

High-molecular-weight kininogen, Fitzgerald factor

Pre-Ka

Prekallikrein, Fletcher factor

Ka

Kallikrein

PL

Platelet phospholipid
Factor VI is not a separate entity and has been dropped.

Schematic of the coagulation system

PK, prekallikrein;
HK, HMW kininogen

Formation of a provisional matrix and the healing process

Schematic representation of the formation of a provisional matrix and the different events that characterize the healing process. CTGF = connective tissue growth factor; ECM = extracellular matrix; FGF = fibroblast growth factor; IL-1 = interleukin 1; MMP = matrix metalloproteinase; PDGF = platelet-derived growth factor; TGF= transforming growth factor- ; VEGF = vascular endothelial growth factor

Major reactions of blood coagulation

Shown are interactions among proteins of the "extrinsic" (tissue factor and factor VII), "intrinsic" (factors IX and VIII), and "common" (factors X, V, and II) coagulation pathways that are important in vivo. Boxes enclose the coagulation factor zymogens (indicated by Roman numerals) and the rounded boxes represent the active