Purpose Acetophenetidin can be formed through two methods‚ Williamson ether synthesis and amide synthesis. By working in groups of two we were able to complete both methods of synthesis routes. The end result should be the synthesis of a similar product‚ by verification between the two individuals. Reaction Experiment and Observations Amide Synthesis of Acetophenetidin The Synthesis reaction began by removing the colored impurities from the p-phenetidine‚ accomplished by mixing
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A- HPTLC Flavonoid profile of methanol extract M. concanensis leaves B- HPTLC Flavonoid profile of methanol extract M. concanensis flowers C- HPTLC Flavonoid profile of methanol extract M. concanensis seeds 4.2.3.1 C) HPTLC Phenol profile of M. concanensis Nimmo. HPTLC finger printing of M. concanensis was done by using selected solvent system Chloroform: Ethyl acetate: Formic acid (50%:40%:10%v/v) for leaf‚ flower and seed extracts‚ visualized under UV 254 and 366 nm showed more
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is used to separate the organic layer‚ and the product is recrystallized for TLC‚ GC/MS‚ and melting point analysis. Pre-Lab 1. What is the limiting reagent in step 1? What is the theoretical yield of amide 1 in figure 3? The amine is the limiting reagent. The theoretical yield is 4.81 grams of amide 1. 2. What is the theoretical yield of Lidocaine? Base calculations on 2‚6-dimethylaniline. The theoretical yield of lidocaine is 5.71 grams. 3. How many molar equivalents of diethyl amine are used in
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In the same year Pradidphol synthesized novel naphthoquinone aromatic amides and evaluated for anticancer activity. Benzamide 80 showed potent inhibition against NCI-H187 cell lines while naphthamides 81 and 83 were the most potent inhibition against KB cells. The decatenation assay revealed that compounds 82 and 83 inhibit
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Starting material may be any lysergic acid derivative‚ from ergot on rye grain or from culture‚ or morning glory seeds or from synthetic sources. Preparation #1 uses any amide‚ or lysergic acid as starting material. Preparations #2 and #3 must start with lysergic acid only‚ prepared from the amides as follows: 10 g of any lysergic acid amide from various natural sources dissolved in 200 ml of methanoic KOH solution and the methanol removed immediately in vacuo. The residue is treated with 200 ml of an 8%
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groups. The amine and amide functional groups are the most polar. In this experiment‚ we found that both these functional groups are found in Caffeine. As a result‚ Caffeine was the most polar out of Acetylsalicylic Acid‚ Ibuprofen‚ Acetaminophen‚ and Caffeine. Aside from Caffeine‚ Acetaminophen has one amide functional group. This makes it the second most polar analgesic. In addition‚ Acetylsalicylic Acid has an ester group. Since ester group is not as polar as either amine or amide groups‚
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The net dipole moment of the molecule Atenolol has amide functional group that makes it the most polar out of three drugs. Because of the greater electronegativity of oxygen‚ the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and‚ to a lesser extent N–C dipole‚ allows amides to act as H-bond acceptors. The presence of N–H dipoles allows amides to function as H-bond donors as well. Therefore‚ atenolol is the most polar drug and
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The early twentieth century led to the discovery of penicillin‚ which revolutionized the use of curative agents to combat many bacterial contagions found around the globe. This was particularly useful in 1943 when the War Production Board outlined a plan to mass-produce a powdered formula of the drug to aid in the WWII American war effort.1 Penicillin’s use on Allied forces in the field reduced the number of amputations and deaths by an estimated 12-15%.2 Despite penicillin’s continued use today
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Chapter 1: Introduction Chapter 1: Introduction Ionic liquids (ILs) can be viewed as a new and remarkable class of solvent. They are also a type of materials that have a long and useful history‚ where the earliest material that meets the current definition of IL was observed in the mid-19th century when a separate liquid phase called the “red oil” was observed in Friedel-Crafts reaction [17]. Over the following years‚ there has been a rapid growing of interest in ILs due to the realization
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Biuret Test Biuret Test • Biuret Test is a chemical test used to show/detect the presence of peptide bonds‚ which are the basis for the formation of proteins. Explanation In the presence of peptides‚ copper (II) ion forms a violet-colored coordination complexes in an alkaline solution. This test can be used to asses the concentration of protein because peptide bonds occur with the same frequency per amino acid in the peptide. According to Beer-Lambert Law‚ the intensity of the color and hence
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