Sideroblastic Anemia Essay
Explain in details regarding the sideroblastic anemia.
- The sideroblastic anemia is a heterogeneous group of blood disorders. This type of anemia will occur because an impaired ability of the bone marrow to produce normal red blood cells. The person who has these anemia can found sideroblasts (abnormal red blood cells) in the blood. Sideroblastic anemia can be categorized into three groups such as reversible, acquired and reversible hereditary.
2. Explain in details regarding the morphology of siderocytes.
- The morphology of siderocytes are different in normal size and shape of red blood cell. The haemoglobin content will contain granules just within the visible range . Monstly the siderocyte contains a single or double granule. Another is …show more content…
Explain in details regarding the stain used for siderocytes.
- The stain used for siderocytes is Perl’s stain or Prussian Blue. It is used to detect the presence of iron in the red blood cells. It is an extremely sensitive test which can even detect single granules of iron in cells. Perl’s stain or Prussian Blue contain three types of reagent. First is potassium ferrocyanide solution is used to detect the presence of iron in the red blood cells. It reacts with ferrous iron in acidic solution to produce the insoluble blue pigment and showed Prussian blue. Dilute hydrochloric acid is acid activation buffer. It is help to create an acidic solution to let potassium ferrocyanide bind with iron to form prussian blue colour. The Carmalum according Mayer is the stain that give the nucleus red colour and background pink colour. Methanol is used to fix and preserve the smear.
4. List the drugs that induced sideroblastic anemia.
- The drugs that induced sideroblastic anemia are antibiotics such as isoniazid, fusidic acid and tetracycline; chemotherapy agents such as busulfan; pain medicines; hormones such as progesterone, and also copper chelating agents such as penicillamine.
5. Explain the clinical manifestations and
- The sideroblastic anemia is a heterogeneous group of blood disorders. This type of anemia will occur because an impaired ability of the bone marrow to produce normal red blood cells. The person who has these anemia can found sideroblasts (abnormal red blood cells) in the blood. Sideroblastic anemia can be categorized into three groups such as reversible, acquired and reversible hereditary.
2. Explain in details regarding the morphology of siderocytes.
- The morphology of siderocytes are different in normal size and shape of red blood cell. The haemoglobin content will contain granules just within the visible range . Monstly the siderocyte contains a single or double granule. Another is …show more content…
Explain in details regarding the stain used for siderocytes.
- The stain used for siderocytes is Perl’s stain or Prussian Blue. It is used to detect the presence of iron in the red blood cells. It is an extremely sensitive test which can even detect single granules of iron in cells. Perl’s stain or Prussian Blue contain three types of reagent. First is potassium ferrocyanide solution is used to detect the presence of iron in the red blood cells. It reacts with ferrous iron in acidic solution to produce the insoluble blue pigment and showed Prussian blue. Dilute hydrochloric acid is acid activation buffer. It is help to create an acidic solution to let potassium ferrocyanide bind with iron to form prussian blue colour. The Carmalum according Mayer is the stain that give the nucleus red colour and background pink colour. Methanol is used to fix and preserve the smear.
4. List the drugs that induced sideroblastic anemia.
- The drugs that induced sideroblastic anemia are antibiotics such as isoniazid, fusidic acid and tetracycline; chemotherapy agents such as busulfan; pain medicines; hormones such as progesterone, and also copper chelating agents such as penicillamine.
5. Explain the clinical manifestations and