Aspirin Synthesis Lab Report
Rebecca Boreham
7/1/14
Chem 2423
Experiment #5
Synthesis of Aspirin
Elizabeth Ajasa
Kaylee Seymour
Lauren Hatfield
Suveda Perikala
Introduction/ Purpose Aspirin is the most commonly used drug in the United States. Forty million pounds are produced each year. The chemical name for aspirin is Acetylsalicylic acid. Aspirin is a pain reliever and a fever reducer. Aspirin originated from the bark of a White Willow Tree. Chewing the bark however is extremely acidicand irritates the mucous membranes of the mouth and stomach.Then, in 1893 a chemist named Felix Hoffman synthesized acetylsalicylic acid. The purpose of this experiment is to synthesize aspirin from salicylic acid and acetic anhydride. To filter and air dry to find the actual …show more content…
Then we added 3 mL of Acetic anhydride and 2 drops of concentrated Sulfuric acid. Swirl the flask for proper mixing.
Then the group proceeded to warm the Erlenmeyer flask and the contents in a water bath to 95°C for 10 minutes. When the temperature was reached and kept for 10 minutes we took the flask away from heat and allowed it to cool to room temperature. We then added 50 mL of cold DI water to the flask. Stirring well to allow the crystals to form. We then filtered the crystals using a vacuum filtration apparatus.
We then allowed the crystals to air dry on the filter paper with the vacuum aspirator still running for several minutes. Afterwards, we transferred the crystals to a watch glass and let sit …show more content…
2. Esters are prepared by condensation (dehydration) of an alcohol with an acid. 3. A class of organic compounds in which a carbon (C) atom is bonded to an oxygen (O) atom by a double bond and to a hydroxyl group (−OH) by a single bond. A fourth bond links the carbon atom to a hydrogen (H) atom or to some other univalent combining group. 4. The reaction using acetic anhydride is faster and produces a higher yield. 5. Molar Mass of salicylic acid = 138 g Molar Mass of acetylsalicylic acid = 180 g 180 g / 138 g = 1.3 g (Theoretical yield) (1.02 g / 1.3 g) x 100 = 78.46% (Percent yield) 6. 7. It is a test used to determine the presence or absence of phenols in a given sample.
Conclusions
The main purpose of this lab is to obtain aspirin by chemical synthesis from salycylic acid by acetylation with acetic anhydride and crystallization. The purpose of crystallization is to create a pure sample. In this experiment, pure aspirin was obtained after filtering out the impurities and excess reagent through filter
7/1/14
Chem 2423
Experiment #5
Synthesis of Aspirin
Elizabeth Ajasa
Kaylee Seymour
Lauren Hatfield
Suveda Perikala
Introduction/ Purpose Aspirin is the most commonly used drug in the United States. Forty million pounds are produced each year. The chemical name for aspirin is Acetylsalicylic acid. Aspirin is a pain reliever and a fever reducer. Aspirin originated from the bark of a White Willow Tree. Chewing the bark however is extremely acidicand irritates the mucous membranes of the mouth and stomach.Then, in 1893 a chemist named Felix Hoffman synthesized acetylsalicylic acid. The purpose of this experiment is to synthesize aspirin from salicylic acid and acetic anhydride. To filter and air dry to find the actual …show more content…
Then we added 3 mL of Acetic anhydride and 2 drops of concentrated Sulfuric acid. Swirl the flask for proper mixing.
Then the group proceeded to warm the Erlenmeyer flask and the contents in a water bath to 95°C for 10 minutes. When the temperature was reached and kept for 10 minutes we took the flask away from heat and allowed it to cool to room temperature. We then added 50 mL of cold DI water to the flask. Stirring well to allow the crystals to form. We then filtered the crystals using a vacuum filtration apparatus.
We then allowed the crystals to air dry on the filter paper with the vacuum aspirator still running for several minutes. Afterwards, we transferred the crystals to a watch glass and let sit …show more content…
2. Esters are prepared by condensation (dehydration) of an alcohol with an acid. 3. A class of organic compounds in which a carbon (C) atom is bonded to an oxygen (O) atom by a double bond and to a hydroxyl group (−OH) by a single bond. A fourth bond links the carbon atom to a hydrogen (H) atom or to some other univalent combining group. 4. The reaction using acetic anhydride is faster and produces a higher yield. 5. Molar Mass of salicylic acid = 138 g Molar Mass of acetylsalicylic acid = 180 g 180 g / 138 g = 1.3 g (Theoretical yield) (1.02 g / 1.3 g) x 100 = 78.46% (Percent yield) 6. 7. It is a test used to determine the presence or absence of phenols in a given sample.
Conclusions
The main purpose of this lab is to obtain aspirin by chemical synthesis from salycylic acid by acetylation with acetic anhydride and crystallization. The purpose of crystallization is to create a pure sample. In this experiment, pure aspirin was obtained after filtering out the impurities and excess reagent through filter