of domains shaped the universe of protein structure. This finding supports the hypothesis that optimization of the kinetic and thermodynamic accessibility of the native fold reduces protein aggregation propensities that hamper cellular functions. `s ´s ¨ Citation: Debe C‚ Wang M‚ Caetano-Anolle G‚ Grater F (2013) Evolutionary Optimization of Protein Folding. PLoS Comput Biol 9(1): e1002861. doi:10.1371/
Premium Protein Protein structure Protein folding
Executive Summary The case‚ Marriott Corporation: The Cost of Capital (Abridged)‚ concentrates on making decisions based on capital asset pricing model (CAPM) and the weighted average cost of capital (WACC) to measure the opportunity cost for investments. Dan Cohrs‚ the Vice President of Finance of Marriott Corporation‚ had to deal with making recommendations for the hurdle rates at Marriott Corporation and its three divisions which are lodging‚ restaurant and contract services. In calculating
Premium Weighted average cost of capital Finance
HBR Case #1 Marriott Corporation: The Cost of Capital Group 16—Tutorial Mon 11:30am Group members LIU Ying‚ Chloe | 1155019350 | LUO Yingying‚ Irika | 1155020931 | TIAN Tian‚ Sarah | 1155019114 | WU Jiajie‚ Jesse | 1155019061 | 17 September 2012 Executive Summary By 1987‚ Marriott Corporation had grown into a large multi-dimensional company with over $5 billion assets in lodging‚ contract services and restaurants. The company enjoyed fast growth in both sales and assets at around
Premium Weighted average cost of capital Debt
Debt Versus Equity Financing ACC/400 May 14‚ 2012 Debt versus Equity Financing Debt versus equity financing is a critical element in the process of managing a business and also the most challenging decision facing managers who require capital to fund their business operations (Schroeder‚ Clark‚ & Cathey‚ 2005). Debt and equity are the two main sources of capital available to businesses‚ and each offers both advantages and disadvantages. This paper will compare and contrast lease
Premium Finance Corporate finance Debt
“The Board of directors should be strengthened by appointing independent directors.” Efficient Corporate Governance has emerged to be an integral part of running a business in today’s scenario; hence it becomes pertinent to understand the nitty-gritties of the role played by the directors of a company to ensure the same. Over the course of time‚ and among important developments in corporate governance and company law reform corresponding to the same‚ have felt the need for independent directors owing
Premium Corporate governance Corporation Board of directors
Marriot Corporation : the Cost of Capital. In front of Dan Chores is the issue of recommending three hurdle rates for each of Marriott Corporation’s three divisions‚ which have significant effect on the firm’s financial and operating strategies as well as its incentive compensation. Marriott Corporation had three major lines of business: lodging‚ contract services and restaurants. Also Marriott had its growth objective‚ to remain a premier growth company. The four components of
Premium Weighted average cost of capital Finance Arithmetic mean
How does Marriott use its estimate of its cost of capital? Does this make sense? Marriott has defined a clear financial strategy containing four elements. To determine the cost of capital‚ which also acted as hurdle rate for investment decision‚ cost of capital estimates were generated from each of the three business divisions; lodging‚ contract services and restaurants. Each division estimates its cost of capital based on: Debt Capacity Cost of Debt Cost of Equity All of the above are calculated
Premium Weighted average cost of capital Finance
Marriot Corporation: Cost of Capital By Xue Fan Background Marriott Corporation began in 1927 with J. Willard Marriott’s root beer stand. Over the next 60 years‚ the business grew into one of the leading companies in industry in United States. In 1987‚ Marriott’s sales grew by 24% and its return on equity stood at 22%. Sales and earnings per share had doubled over the previous 4 years‚ and the company strategy was aimed at continuing this trend. Marriot Corporation had three major lines
Premium Generally Accepted Accounting Principles Marriott International Financial ratios
Case #3 “Marriott Corporation” The Cost of Capital” What is the weighted average cost of capital for the Marriott Corporation and cost of capital for each of its divisions? – What risk-free rate and risk premium did you use to calculate the cost of equity? – How did you measure the cost of debt? – How did you measure the beta for each division? Solution What risk-free rate and risk premium did you use to calculate the cost of equity? – Risk-free rate proxy The risk-free
Premium Arithmetic mean Weighted average cost of capital Average
The 1950’s-60’s70’s-80’s Miranda Moultrie Nixon Back Again The United States presidential election of 1968 was the 46th quadrennial presidential election‚ held on Tuesday‚ November 5‚ 1968. Moon Shot On July 21‚ 1969‚ President Nixon spoke from the Oval Office to Apollo 11 astronauts Neil Armstrong and Edwin Aldrin at the Sea of Tranquility on the Moon. Apollo 11 was the spaceflight that landed the first humans on the Moon‚ Americans Neil Armstrong and Woodstock A village in New York state
Premium Apollo 11 Richard Nixon Neil Armstrong