Lab 3: Grignard Synthesis Objective: The goal of this lab is to synthesize a Grignard reagent from bromobenzene and magnesium metal in diethyl ether. This same Grignard reagent would then be used to prepare a tertiary alcohol and then purify and characterize the product. Table of Reagents: Name Chemical formula Melting Point Boiling Point Density Safety Hazards Diethyl ether C4H10O -116.3°C 34.6°C 0.7134 g/ml Flammable Bromobenzene C6H5Br -30.6°C 156°C 1.5 g/ml
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The purpose of this experiment was to synthesize triphenylmethanol from a Grignard reagent. The Grignard reaction technique was used in this synthesis but due to the fact that it is such a strong nucleophile and base‚ it was important to prevent water from interfering with the Grignard reaction. Purity of the product was determined by measuring the melting point. Reagent Table: Structure Name Molecular formula Molar mass Density Melting point Boiling Point Diethyl ether C4H10O
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The Grignard Reaction Abstract Through the use of the Grignard reaction‚ a carbon-carbon bond was formed‚ thereby resulting in the formation of triphenylmethanol from phenyl magnesium bromide and benzophenone. A recrystallization was performed to purify the Grignard product by dissolving the product in methanol. From here‚ a melting point range of 147.0 °C to 150.8 °C was obtained. The purified product yielded an IR spectrum with major peaks of 3471.82 cm-1‚ 3060.90 cm-1‚ 1597.38 cm-1‚ and 1489
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Station 1. Grignard Reaction Post-lab report Fill out the appropriate sections below. Show all work. Your calculated answers need to match the answers in the table. Also‚ attach the benzophenone and product spectra. Indicate appropriate stretches including differences in both spectra. Results | | Amounts and units | |Initial volume of bromobenzene
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Grignard reaction Abstract: In this laboratory‚ triphenylmethanol was synthesised from reacting benzophenone and bromobenzene using Grignard reaction. As the reaction was to set up to produce a Grignard reagent and then recrystallize it to obtain pure sample. The percentage yield obtained was 55% and its melting point was 161 co which is within the literature value 160-163 co. In addition to that the IR spectroscopy confirmed the molecule structure to be triphenylmethanol. Introduction: The Grignard
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Grignard Reaction: Synthesis of Triphenylmethanol Hai Liu TA: Ara Austin Mondays: 11:30-2:20 Abstract: In this experiment‚ phenylmagnesium bromide‚ a Grignard reagent was synthesized from bromobenzene and magnesium strips in a diethyl ether solvent. The Grignard reagent was then converted to triphenylmethanol‚ a tertiary alcohol with HCl. The reaction for phenylmagnesium bromide was: The reaction for Grignard to triphenylmethanol was: In the formation of the Grignard reagent
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The Grignard Synthesis of Triphenylmethanol Abstract: Grignard synthesis of triphenylmethanol was achieved by use of the Grignard reagent phenyl magesium brominde. The organometallic grignard reagent was synthesized by use of a reflux apparatus recrystallization techniques. Once synthesized it was used in a Grignard reaction that involved nucleophilic addition to a carbonyl in order to make triphenylmethanol. The final product was solidified and recrystallized and spectral data was obtained
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formation of phenylmagnesium bromide‚ and second the reaction of the phenylmagnesium bromide with the carbonyl compound. However‚ before any of this could be done‚ the refluxing apparatus for the Grignard reaction was to be flame dried until no moisture remained inside because any water would cause the reagent to decompose and an alkane to form. The reaction would subsequently fail. Drierite was placed inside a plastic drying tube as a drying agent‚ absorbing all the moisture from the solvents that would
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Grignard Synthesis of Tirphenylmethanol David Szuminsky Organic Chemistry Lab II Shaopeng Zhang Monday 1PM 2/10/14 & 2/24/14 - Abstract A sample of triphenylmethanol was prepared using Grignard synthesis techniques. Reflux was used in order to speed up the reaction and the final product was purified using recrystallization methods. The percent recovery and percent yield were 80.46% and 47.526%‚ respectively. A melting point range of 85-87oC was obtained from
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Experiment C. Aim: To protect one of two carbonyl groups (C1) in order to allow the other to react twice with a Grignard followed by removal of the protecting group by acid hydrolysis to give final product (C2). Method: Ethyl acetoacetate (30.03g)‚ ethylene glycol (15.01g) and toluene-p-sulphonic acid (0.13g) were added to a 250 cm3 round bottomed flask‚ containing a stirrer bar and toluene (100 cm3)‚ fitted with a condenser and dean-stark head. Solution was heated strongly under reflux using
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