In order to carry out a detailed stability study of OXP and CYPZ in combination‚ it is essential to have a single stability-indicating assay method which can separate both drugs along with all of their degradation products from each other. Therefore‚ a RP-HPLC method was developed and optimized. Optimization of the chromatographic conditions In this study‚ the different experimental parameters were carefully studied and optimized in order to improve the performance and system suitability parameters
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Abstract: The optical and photocatalytic properties of Nb2O5 sculptured thin films (STF) are investigated. Films are synthesized via sol- gel route using spin coating technique. The sol is prepared from niobium ethoxide. The films are prepared at different rpm to tailor the thickness. The structures of the films are investigated through XRD measurements. Refractive index‚ extinction coefficient and thickness of the films are determined from Variable Angle Spectroscopic Ellipsometery. The absorbance
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According to Stability testing of new drug substances and products‚ a guideline of ICH desires that to clarify the inherent stability characteristics of the active component stress testing was implemented. The aim of this work was to carry out the stress degradation studies on the Lamivudine‚ Abacavir and Dolutegravir using the proposed method. Formulation drug products were exposed to thermal stress‚ oxidative stress‚ photolytic‚ hydrolytic stress under acidic medium and basic medium. An ideal
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For this lab‚ we had to figure out which antacid was the most effective out of all 3 of them. To figure out which one was the most effective‚ the antacid which took the most amount of drops of Hydrochloric Acid (HCl) to neutralize the antacid would be most effective. Based on the results‚ Life Brand Milk of Magnesia was the most effective out of the three antacids because it took 120 drops of hydrochloric acid (HCl) to neutralize the antacid. The active ingredient in Life Brand Milk of Magnesia is
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Paragraph 1 In this paragraph‚ the structural and chemistry differences between quartz‚ α-FePO4 and β-FePO4 will be discussed. Quartz do have some similarities with the other 2 components. The structure of quartz‚ similarly depends on the temperature of the environment. Quartz can exist as an alpha or beta form. This is one similarity between the 3. The difference between α-FePO4 and β-FePO4‚ is that α-FePO4 is the most common form of existence for FePO4 and is structurally similar to the alpha
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A simple‚ precise‚ accurate and rapid High-Performance Thin Layer Chromatographic method has been developed and validated for the simultaneous estimation of of ellagic acid‚ chlorogenic acid‚ gallic acid and quercetin in the leaf extract of Terminalia tomentosa and its Formulation. The stationary phase used was precoated silica gel 60F254.The mobile phase used was a mixture of Butyl acetate: Formic Acid: Distilled Water 14:5:5 (v/v). The detection of spots were carried out at 254 nm. This HPTLC method
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A simple‚ specific‚ accurate and rapid reversed phase high performance liquid chromatographic method was developed for the simultaneous estimation of cilnidipine and chlorthalidone‚ using a Hiber® C18 (25cm x 4.6 mm)‚ Lichrospher® 100‚ RP-18 e (5µm) column and a mobile phase composed of phosphate buffer(pH 4.0 adjusted with orthophosphoric acid) : Acetonitrile (30:70‚ v/v). The retention times of Cilnidipine and Chlorthalidone were found to be 3.967 min and 6.427 min‚ respectively. Linearity was
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Research Question: How can different masses of salt affect the percentage of transmitted light? Variables – Independent – • Mass of salt‚ the salt added into the distilled water in grams (0.1‚ 0.5‚ 0.75‚ 1‚ 1.5) Dependent – • Percentage of transmitted light through the solution using 5 different mass of salt and a constant availability of 2g of sugar as source of food. (there are 5 trails for each conical flask representing 5 different salt masses) Controlled – What is being Controlled
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Abstract: A simple‚ eco-friendly‚ stability-indicating HPLC method was developed for the determination of Donepezil Hydrochloride (DH) in tablet dosage form in presence of its pharmacopoeial related compound (Donepezil related compound A) and its different degradation products. The chromatographic conditions were optimized to achieve the highest performance parameters using Zorbax Eclipse Plus C18 rapid resolution column (4.6 X 100 mm‚ 3.5 µm)‚ with a mobile phase composed of 72.5 % acetate buffer
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Experiment Separation of Organic Compounds by Acid-Base Extraction Techniques 5 A commonly used method of separating a mixture of organic compounds is known as liquid-liquid extraction. Most reactions of organic compounds require extraction at some stage of product purification. In this experiment you will use extraction techniques to separate a mixture of an organic acid‚ a base‚ and a neutral compound. Organic acids and bases can be separated from each other and from neutral compounds
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