Sickle cell anemia is a genetic disease that affects the shape and functionality of red blood cells. It is caused by a mutation in the DNA of the protein‚ hemoglobin‚ specifically in the beta chain. There are 531 base pairs in this DNA strand. Substitution or point mutation occurs‚ causing “GAG” to become “GTG”. This results in valine being created instead of glutamate. The mutation causes the hemoglobin to cling together in low oxygen levels and the red blood cell changes shape‚ preventing it from
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SICKLE CELL ANAEMIA Sickle cell anemia is an inherited condition. People with sickle cell anemia inherit two copies of the sickle cell gene‚ one from each parent. The sickle cell gene makes abnormal hemoglobin called Hemoglobin-S. The sickle cell gene is a trait due to a change in ONE nucleotide in the DNA sequence that leads to a change in ONE amino acid that changes how the hemoglobin protein folds. This change in the structure of the hemoglobin protein leads to a change in the shape of
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Critical Care Nursing: Sickle Cell Anemia Critical Care Nursing 10/15/2009 Sickle cell anemia affects millions of people worldwide. Sickle cell anemia is a disease in which your body produces abnormally shaped red blood cells. They don’t last as long as normal‚ round red blood cells‚ which leads to anemia. Sickle cells contain abnormal hemoglobin that causes the cells to have a sickle shape. Sickle-shaped cells don’t move easily through your blood vessels. They’re
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Sickle-Cell Anemia is a genetic blood disorder caused by the presence of an abnormal form of hemoglobin. These hemoglobin molecules tend to aggregate after unloading oxygen forming long‚ rod-like structures that force the red cells to assume a sickle shape. Unlike normal red cells‚ which are usually smooth and malleable‚ the sickle red cells cannot squeeze through small blood vessels. When the sickle cells block small blood vessels‚ the organs are deprived of blood and oxygen. This leads to periodic
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Conclusion 1 Based on what you know about blood‚ why would having a sickle cell anemia crisis result in a reduced red blood cell count‚ an elevated white blood cell count‚ and a reduced hematocrit? There’s a reduced RBC count‚ elevated WBC count‚ and a reduced hematocrit because of the shape of the RBC. The sickle cell anemia causes the RBC to have a different shape; a crescent and rigid shape and there are not a lot of them. So because of that‚ there’s more WBC and a reduced hematocrit. Also‚ the
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Communicable Disease * Keep in mind all have fever‚ swollen LN‚ rash etc. Scarlet Fever: * Cause: Group A beta Hemolytic Streptococcus * Spread via direct contact/droplet * May lead to RF * Uvula/pharynx beefy red; tonsils have white exudate‚ pinpoint lesions on palate * Sandpaper rash * Pastina Sign: hyperpigmentation at joints * TONGUE (white furry white strawberry strawberry ) * So throat culture if they have strept/sore throat *** Anybody with a sore throat
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What Is Sickle Cell Anemia? Sickle cell anemia (uh-NEE-me-uh) is the most common form of sickle cell disease (SCD). SCD is a serious disorder in which the body makes sickle-shaped red blood cells. “Sickle-shaped” means that the red blood cells are shaped like a crescent. Normal red blood cells are disc-shaped and look like doughnuts without holes in the center. They move easily through your blood vessels. Red blood cells contain an iron-rich protein called hemoglobin (HEE-muh-glow-bin). This protein
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Crohn and his team founded a disease that we have now known as Crohn’s disease. (The Secret History of Crohn’s Disease) Dr. Crohn didn’t know much about the cause and development of Crohn’s back then‚ and it still seems to be that way today. There has been a great amount of improvement on discovering the source of Crohn’s‚ but there is still much to be done. More research and funding need to be put towards Crohn’s disease in order to find an exact cause of the disease. If we make this possible‚ then
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Condition: Maple Syrup Urine Disease Maple Syrup Urine Disease is a genetic disorder caused by mutation in the DBT‚ DLD‚ BCKDHB‚ and BCKDHA genes‚ which codes for Branched Chain Keto Acid Dehydrogenase (BCKD). Normally‚ BCKD would process the keto acid derivatives for leucine‚ isoleucine‚ and valine and continue them on their respective metabolic pathways. As a result of these breaks in the metabolic pathway‚ the patient may suffer from mental retardation‚ lethargy‚ poor feeding habits‚ vomiting
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CDC‚ sickle cell disease is a hereditary disease where the red blood cells have an unusual shape that prevents them from moving easily through the blood vessels and satisfying their metabolic needs causing them to die faster. People with sickle cell disease often experience pain due to the sickle cell blocking the small blood vessels‚ anemia due to the low healthy blood cell count‚ and infections. Although it is impossible to obtain accurate information about everyone that has the sickle cell disease
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