Sickle Cell Anemia first came into the view of the world around 1910 when Dr. James Herrick; a cardiologist‚ had a patient who complained of pain and described symptoms that sounded like anemia. He handed the case down to his assistant who‚ after taking a blood sample‚ discovered that the patient’s blood cells were not shaped like normal blood cells. When the patient’s blood cells were compared to normal blood cells‚ they appeared to be “sickle shaped”. After seeing this for himself Dr. Herrick took
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Sickle cell anemia is a genetic disease that affects the shape and functionality of red blood cells. It is caused by a mutation in the DNA of the protein‚ hemoglobin‚ specifically in the beta chain. There are 531 base pairs in this DNA strand. Substitution or point mutation occurs‚ causing “GAG” to become “GTG”. This results in valine being created instead of glutamate. The mutation causes the hemoglobin to cling together in low oxygen levels and the red blood cell changes shape‚ preventing it from
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Differential diagnose 1: Sickle Cell Anemia A 17-year-old African American female presented to the clinic with the following symptoms‚ chest and abdominal pain‚ and jaundice eyes. Her vital signs revealed B/P 98/50‚ pulse 112‚ respiration. 28 and temp. 99.9. EKG and chest x-ray completed with the result within normal range. She was discharged‚ and within four hours returned to the ER. Sickle cell disease is defined as a group of heredity disorder characterized by abnormal hemoglobin‚ called hemoglobin
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Cell’s July 18‚ 2011 Sickle cell anemia is an inherited blood disease that means you are born with it and it lasts a lifetime. People with sickle cell anemia inherit two variant or sickle cell genes‚ one from each parent. In the United States‚ sickle cell anemia affects about 72‚000 people. About 2 million Americans carry the sickle cell trait but about 1 in 12 African Americans have the trait. The signs and symptoms of sickle cell anemia are different in each person. Some people
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Sickle Cell Anemia is a hereditary disease that changes the smallest and most important components of the body. A gene causes the bone marrow in the body to make sickled shapes‚ when this happens; it causes the red blood cell to die faster. This is what causes Hemolytic Anemia. Older children and adults with sickle cell disease may experience a few complications‚ or have a pattern of ongoing problems that shorten their lives. The most common and serious complications of sickle cell disease are anemia
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SCD also known as sickle cell disease affects the blood and cardiovascular system. There are six different types of SCD. The following discussion will include cause‚ symptoms‚ diagnosis‚ treatment and prevention. The proper education on this disease will give patients and the public a better knowledge of the common unfamiliarity with SCD. The cardiovascular system consists of the heart‚ arteries‚ capillaries‚ veins‚ and blood. The organs in the cardiovascular system are a vital part of the human
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Evolution of Sickle Cell Sickle Cell was discovered in the United states although it originated in Africa . The sickle cell disease (SCD) describes traits of an inherited red blood cell disorder‚ having SCD means you have abnormal hemoglobin‚ called hemoglobin S or sickle hemoglobin‚ in your red blood cells. What is hemoglobin u might ask?! Well Hemoglobin is a protein in red blood cells that is suppose to carry oxygen throughout the body. But when a sickle cell trait is “Inherited” it could
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Sickle-Cell Anemia is a genetic blood disorder caused by the presence of an abnormal form of hemoglobin. These hemoglobin molecules tend to aggregate after unloading oxygen forming long‚ rod-like structures that force the red cells to assume a sickle shape. Unlike normal red cells‚ which are usually smooth and malleable‚ the sickle red cells cannot squeeze through small blood vessels. When the sickle cells block small blood vessels‚ the organs are deprived of blood and oxygen. This leads to periodic
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Sickle cell disease is present usually in those of African or Mediterranean descent (Saladin 2007). About 1.3% of African Americans have sickle cell (Saladin‚ 2007). Sickle cell was originated in Africa where malaria was killing a vast number of people (Saladin‚ 2007). The sickle cell hemoglobin is not able to be digested by the parasites that cause malaria‚ making those with sickle cell resistant to malaria (Saladin‚ 2007). This paper will discuss a normal erythrocyte compared to an erythrocyte
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SICKLE CELL ANEMIA Tina Thompson‚ Ashley Scott‚ Araceli Galindo‚ Roshanda Dixon‚ Kristen Wyatt‚ Kimberly Dennis What is Sickle Cell Anemia? Sickle cell anemia is a severe hemolytic anemia resulting in a sickle shaped hemoglobin molecule. It is an inherited disorder with some having sickle cell trait and some having sickle cell disease. The sickle hemoglobin gene is known as the HbS gene. It is found predominantly in people of African descent and occasionally in those of Mediterranean descent
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