Do you know that tall‚ skinny kid that towers over everyone? There might be a genetic disorder to explain why he is like that. Have you ever heard of something called Marfan syndrome or MFS? It is a genetic disorder that about one in every five thousand people have and there is a fifty percent chance that it can be passed on to the next generation ("What Is Marfan Syndrome?"). Marfan syndrome is an abnormal condition characterized by elongation of the bones‚ and abnormalities in the cardiovascular
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The Roux Lab is one of the labs at Sanford Research that focuses on proteins. The goal of the lab is to map the proteins of the nuclear envelope using BioID. This may sound like a simple goal but figuring out where each protein is located but it is a daunting task. With the lab trying to map the proteins‚ it is necessary to develop efficient ways of seeing how proteins interact. In the past years of the Roux lab‚ they have developed a system to see which proteins interact with other proteins
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Coagulation factor V (FV) circulates in the bloodstream in an inactive form (procofactor) and is activated to factor Va (FVa) by thrombin. Thrombin cleaves away the large inhibitory B-domain of FV which resolves the molecule into a heterodimer that is stabilized through non-covalent interactions between heavy (A1-A2) and light (A3-C1-C2) chains. A recombinantly expressed truncated B-domain variant of factor V (FV-DT) exhibits constitutive FVa-like activity even in the absence of proteolysis. FV maintains
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An enzyme rotates around the double helix unwinding and flattening the structure. The double helix being unwinded is not a natural shape to have for dsDNA. Once the dsDNA is “unzippered”‚ ssDNA can only have new nucleotides partnered with it in one direction. each strand of the chromosome serves as a template to specify as a new complementary DNA strand. Dna acts as a template because each strand becomes a daughter strand by pairing the bases. Replication happens when the helicase attaches and breaks
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The very first motion picture of a galloping mare filmed in 1878 by the British photographer‚ Eadweard Muybridge is now the first movie ever to be encoded in the DNA of a living cell by Harvard researchers‚ where it can be retrieved at will and multiplied indefinitely as the host cells divide and grow. “What we’re trying to develop is a molecular recorder that can sit inside living cells and collect data over time.” said Seth Shipman‚ a neuroscientist at Harvard
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1. 2. 3. All of Allison’s eggs will carry the X chromosome and 50% of Allison’s egg cells will carry the recessive allele (hexa). 4.a. There is a 25% chance that Allison and Tim will have a baby boy who is heterozygous for Tay-Sachs. b. No‚ the baby boy will not have Tay-Sachs he will be a carrier for the disease. The boy would only have the disease if he was homozygous recessive. | X | Y | X | XX | XY | X | XX | XY | 1:2 1:2 | T | t | T | TT | Tt | t | Tt | tt
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Deoxyribonucleic acid (DNA) is the fundamental molecule of life encoding the genetic code for the development and functioning of every living organism and a large variety of viruses. RNA‚ proteins‚ and DNA are the main macromolecules‚ which are necessary for every form of life. The genetic system is encoded in the form of a sequence of nucleotides (guanine‚ adenine‚ thymine‚ and cytosine)‚ which are denoted by the letters G‚ A‚ T‚ and C. Most DNA molecules consist of double-stranded helices‚ composed
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Accepted: 27 September 2007 / Published online: 17 January 2008 # Springer Science + Business Media‚ LLC 2007 Abstract We explored the possibility of protecting Penaeus monodon against white spot syndrome virus (WSSV) infection via interference RNA technology by oral administration of bacterially expressed WSSV VP28dsRNA. Shrimp were given dsRNA orally via two methods. In the first method‚ pellet feed was coated with inactivated bacteria containing overexpressed dsRNA of the WSSV VP28 gene
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5’-CAG AAG AAA AUU AAC AUG UAA-3’ mRNA sequence 3’-GTC TTC TTT TAA TTG TAC ATT-5’ DNA template strand We get the mRNA sequence due the transcription process‚ which gives us the RNA bases that are complementary to the DNA template strand that uses uracil opposite to adenine. The RNA polymerase which is an enzyme that moves from the 3’ to 5’end on DNA template strand to synthesis mRNA from 5’ to 3’. b. What is the amino acid sequence produced by translation of the mRNA sequence
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in terms of selection mechanisms shaping localizable trajectories and/or resulting in more globalized regimes. By expanding the data with patents and scholarly publications‚ we demonstrate the use of this multi-perspective approach in the case of RNA Interference (RNAi). The possibility to develop an "Innovation Opportunities Explorer" is specified. Comments: | Technology Analysis and Strategic Management (forthcoming in 2013) | Subjects: | Digital Libraries (cs.DL); Physics and Society (physics
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