Pott’s disease Definition Pott’s disease is a presentation of extrapulmonarytuberculosis that affects the spine‚ a kind of tuberculous arthritis of the intervertebral joints. It is named after Percivall Pott (1714-1788)‚ a London surgeon who trained at Barts. Scientifically‚ it is called tuberculousspond ylitis and it is most commonly localized in the thoracic portion of the spine. AKA: Pott’s syndrome‚ Pott’s caries‚ Pott’s curvature‚ angular kyphosis‚ kyphosis secondary to
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Serum creatinine concentration shows a relationship with GFR‚ making it specific‚ but not a sensitive measure of GFR. The creatinine pool is influenced by nutritional state‚ hepatic disease gender‚ ethnicity‚ protein intake‚ and age (Slack et al.‚ 2010). In liver cirrhosis‚ the decrease in serum creatinine is due to a 50% reduction in hepatic production of creatine; increases in volume of distribution due to accumulation of extracellular fluid‚ ascites‚ edema‚ loss of muscle mass and malnutrition
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Gastric mucosal lies over the epithelium. The secretion of mucus and bicarbonate serve as the first line of defense in the stomach and work to maintain a normal pH. Mucus and bicarbonate both protect the stomach against acid‚ while gastro-mucosal prostaglandins increase this barrier. Its important that the stomach receives a rich blood supply to keep its integrity. When a break in the mucosal lining occurs hydrochloric acid is able to reach the epithelium. When the epithelium is injured dysfunction of
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After completing that course‚ each time I filled a medication at work‚ it provoked me to think about its mechanisms of action. For example‚ Tylenol has a diverse effect on the central nervous system. It inhibits the prostaglandins to increase pain threshold‚ and interferes with the hypothalamus to reduce fever. This perspective taught me medications can have multiple purposes. Ultimately‚ this experience initiated my curiosity in the clinical research side of pharmacy.
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Naphthalimide derivatives are classified under intercalators‚ having a flat aromatic or heteroaromatic moiety and basic side chains. Amonafide is one of the most widely studied naphthalimides‚ which binds DNA by intercalation and also as Topoisomerase II inhibitors. The napthalimides showed excellent activity in breast cancer trials but failed in phase III trials due to its side effects and bone marrow toxicity [54]. The justly Naphtalene diimide (NDI) scaffold achieved recently as intercalators
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CYTOCHROME P450 2S1 Cytochrome P450s (CYPs) are monooxygenase proteins that catalyze the metabolism of exogenous and endogenous substrates. CYPs function as enzymes and are found in all kingdoms of life. The P in P450 refers to pigment and 450nm refers to the wavelength of CYPs in solution exposed to carbon monoxide (CO). CYPs belong to the superfamily of proteins containing a heme (iron) cofactor active site. The heme active site is tethered to the CYP protein via thiolate ligand derived from
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Home » Nursing Care Plans » 5 Bronchial Asthma Nursing Care Plans 5 Bronchial Asthma Nursing Care Plans 5 Bronchial Asthma Nursing Care Plans Posted by: Matt Vera in Nursing Care Plans February 11‚ 2012 Updated: July 3rd‚ 2013 0 4‚388 Views tweet Definition Contents 1 Definition 2 Nursing Care Plans 2.1 Ineffective Airway Clearance 2.2 Ineffective Breathing Pattern 2.3 Impaired Gas Exchange 2.4 Fatigue 2.5 Risk for Activity
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1. Briefly explain how does the body maintain homeostasis? Homeostasis is a existence and maintenance of a relatively constant internal environment. Homeostasis is maintain by negative and positive feedback mechanism. Most homeostatic control mechanisms are negative feedback mechanisms. In these system‚ the output shut off the original stimulus or reduce its intensity. These mechanisms cause the variable to change in a direction opposite to that of the initial change‚ returning it to its “ideal”
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Abortion Report I have chosen for my topic Abortion. I think that it is a topic that is very important in today’s society however it is often dodged or avoided. Different Presidents say different things and have different stances about it‚ and often it is had to know what to think about it. Basically there are two different ways of looking at it: Pro-Choice‚ which takes the stance of saying that it is the woman’s choice if she wants to have an abortion and that it is only her business. So
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MODULE 3 Innate Immunity 1. Describe the composition‚ function‚ and the purpose of physical‚ mechanical‚ and biochemical barriers‚ The first line of defense against damage and infection is composed of tightly associated epithelial cells including those of the skin and the mucous membranes of the GI‚ GU‚ and respiratory tracts. The highly interconnected mucosal epithelial cell junctions prohibit the passage of microorganisms. Many infectious microorganisms are mechanically cleansed
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