The nAChR is unusual among receptors in that agonist-induced desensitization leads to an up-regulation of the receptor. Ligand interactions occur with various discrete forms of the receptor as originally proposed in 1958 by Katz and Thesleff‚ e.g.‚ open‚ resting‚ and desensitized states that are in equilibrium (Lena and Changeux‚ 1993). In addition to the acetylcholine (ACh) binding site‚ the nAChR‚ like other LGICs‚ e.g.‚ GABAA(benzodiazepine‚ neurosteroid‚ and barbiturate) andN-methyl-D-aspartate
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Statement of Purpose(SOP) for Pharmacy‚ Pharmaceutics The urge to achieve and prove myself among the greats in the history of science has been my ambition from the day I was first introduced to the captivating concepts of science and medicine in particular. The mental ability to approach a problem with the right amalgam of logic and reasoning has supported me in inching towards my goal. As a first step out of school I decided to take up biology‚ physics & chemistry as my optional subjects which
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a firm foundation in topics such as Pharmaceutics‚ Medicinal Chemistry‚ Analytical Chemistry‚ Biochemistry‚ Organic Chemistry‚ Inorganic Chemistry‚ Physical Pharmacy‚ Instrumental Analysis‚ Microbiology and Immunology‚ Clinical Administration‚ Pharmacology‚ Bio-pharmaceutics‚ Biostatistics and other topics related to pharmaceuticals comprehensively taught by highly qualified and competent faculty members and through interaction with industrialists. Undergraduate study in the field of pharmacy helped
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What are the implications of personal genomes for drug discovery and development ? In the past decade‚ increasing amounts of dollars have been spent on drug development yet the amount of new drugs entering the market per year remains the same. Furthermore with 200 billion dollars of patents expiring in the past four years (Witty‚ 2010)‚ innovative pharmaceutical companies will need to look at new approaches to discover drugs. With the human genome being sequenced in 2003‚ a new field of science
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For hundreds of thousands of years now‚ different plants were able to be of use for drinks‚ antibiotics‚ dyes‚ beauty cosmetics‚ etc. to upgrade quality of life. The Panax Ginseng‚ found in mostly Korea and China‚ is regarded as one of the most important and useful herbs around the world‚ particularly in Asia. When its name is said in Chinese‚ it means “root of men”‚ which is associated to the form of the roots‚ which have a striking resemblance to legs of men. People have been using many different
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1. TDI (The Tropical Disease Initiative) This programme was started because of lack of innovation and availability of drugs in tropical regions‚ especially; for diseases that are indigenous to the tropical regions. Drugs for diseases like the African sleeping sickness‚ dengue fever‚ kwashiorkor‚ malaria‚ tuberculosis etc.‚ are only 1% of the newly developed drugs. Due to patent incentives for the Western pharmaceutical companies and lack of payers for the drugs in the Tropics‚ drug availability is
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Suboxone Biological Psychology Suboxone | Addiction psychology has made a great impact on the field of biological psychology‚ especially when it comes to subjects such as | |psycho-pharmacology. The abuse of prescription pain medicine has risen to an estimated 9 million in America alone who take the medication for | |non-medical reasons. The psychology field has had a new revolution in addiction control called Suboxone. In order for psychiatric doctors or other|
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Assessment of the Medication Safety Practices in Selected Government and Private Hospitals In Quezon City A Research Presented To The School Of Pharmacy Centro Escolar University In Partial Fulfillment Of The Degree of Bachelor Of Science in Pharmacy By: Bolaños‚ Jam Claudinee S. Café‚ Cecille Ann A. Carlos‚ Diana Ruth B. Deniega‚ Leslie Ann L. Fernando‚ Khristine Mae C. Gagala‚ Pauline Rose A. Vargas‚ Kristine Joy M. March 2014 ACKNOWLEDGEMENT It is with pleasure that
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CHAPTER ONE 1.0 INTRODUCTION 1.1 BACKGROUND TO THE STUDY Pharmacoepidemiological studies attempt to link clinical pharmacology to epidemiology. Drug utilization research is an integral component of pharmacoepidemiology that focuses not only on the medical‚ but also socio-economic implications of drug distribution and use in a large population‚ with the primary aim of ensuring the safe‚ effective and rational drug use. Medical concerns encompasses the actual or potential risks that are inherent in
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Beginning as a small scale manufacturer of chemical in the United States‚ Merck Research Labs (MRL) became the top notch research institution in the pharmaceutical industry by World War II. By attracting the top talent in chemistry‚ biology‚ and pharmacology‚ MRL emerged as the leader in human pharmaceuticals with the release of highly necessary drugs to treat infections‚ and tuberculosis. MRL focused their strengths on three key areas: vitamins‚ antibiotics‚ and hormones. With the best scientists
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