Aspirin Synthesis Introduction Out of all the pharmaceutical drugs in the worlds‚ aspirin is made the most. Any potential pharmacist must be familiar with synthesizing the drug. The goal of this lab is to synthesize as much pure aspirin as possible. The reactants‚ acetyl anhydride and salicylic acid‚ must react in phosphoric acid. With phosphoric acid as a catalyst‚ the reaction yields aspirin and acetic acid. The equation for the reaction is as follows: “(CH3CO)2O + HOC6H4COOH □(→┴yields ) CH3CO2C6H4CO2H
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transfer 0.8 ml of this solution and the reaction was allowed to proceed until the solution turns brown and cloudy. The conical vial was then rinsed with 2 ml of anhydrous ether to get any remaining solution into the reaction vessel. Simultaneously‚ 1.09 g of benzophenone and 2ml of anhydrous ether were added to a 3ml conical vial and gently stirred. The reaction vessel was taken off of the hot plate and allowed to cool. The benzophenone was then added to the reaction mixture while stirring vigorously.
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Rebecca Boreham 7/1/14 Chem 2423 Experiment #5 Synthesis of Aspirin Elizabeth Ajasa Kaylee Seymour Lauren Hatfield Suveda Perikala Introduction/ Purpose Aspirin is the most commonly used drug in the United States. Forty million pounds are produced each year. The chemical name for aspirin is Acetylsalicylic acid. Aspirin is a pain reliever and a fever reducer. Aspirin originated from the bark of a White Willow Tree. Chewing the bark however is extremely acidicand irritates the mucous membranes
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Introduction In a Grignard reaction‚ a Grignard reagent (R–MgX) adds to the carbonyl group in an aldehyde or ketone to form an alcohol (Figure 1). The reaction of a Grignard reagent with formaldehyde can be to synthesize a primary alcohol‚ with any other aldehyde can be used to synthesize a secondary alcohol‚ while the reaction with ketone is useful in the synthesis of a tertiary alcohol. Figure 1. General reaction mechanism of a Grignard Reaction The preparation of the Grignard reagent involves
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this lab‚ caproic acid was synthesized in a multi-step process that involved the synthesis of three intermediates – diethyl n-butylmalonate‚ potassium n-butylmalonate‚ and n-butyl malonic acid respectively. An IR was used to characterize the starting material‚ n-bromobutane‚ and the first intermediate‚ diethyl n-butylmalonate; while IR and NMR were used to characterize the final product‚ caproic acid. Reactions‚ Mechanism and Theory Caproic acid a.k.a n-hexanoic acid is a carboxylic acid derived
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The Grignard Synthesis of Triphenylmethanol Abstract: Grignard synthesis of triphenylmethanol was achieved by use of the Grignard reagent phenyl magesium brominde. The organometallic grignard reagent was synthesized by use of a reflux apparatus recrystallization techniques. Once synthesized it was used in a Grignard reaction that involved nucleophilic addition to a carbonyl in order to make triphenylmethanol. The final product was solidified and recrystallized and spectral data was
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Theory: Esters are derived from carboxylic acids and alcohols with the presence of a catalyst. A carboxylic acid contains the -COOH group‚ and in an ester the hydrogen in this group is replaced by a hydrocarbon group of some kind. Sulfuric acid (H2SO4)is used as a catalyst for this reaction in order to accelerate the rate at which the product is formed. The general formula of an ester is RCOOR’ in which R is the alkyl group that comes from the carboxylic acid while R’ is the alkyl group that comes from
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BCH3015 Organic Chemistry Name: Chun Ka Yuen (52180145) Group: C Date of experiment: 30/3/2012 Date of report: 3/4/2012 Experiment 5: Polymers Aim: This experiment is to prepare polymeric materials including polystyrene‚ Nylon6‚ 10‚ and cellulose triacetate. Introduction: A polymer consists of repeating subunits in the form of –A-A-A-A-A- or A-B-A-B-A-B-‚ where A and B are different subunits. These sub-units are typically connected
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4/2/14 Period: 1st Chemistry Sour Acids and Bitter Bases Purpose: The purpose of this lab was to observe the different reactions formed between various acids and bases with the aid of indicators. Equipment: 1. Safety goggles. 2. Droppers. 3. Red Litmus paper. 4. Blue Litmus paper. 5. pH paper. 6. Well plate. 7. Micro spatula. Materials: 1. Zinc. 2. Magnesium. 3. Iron. 4. Copper. 5. HCL. 6. HC₂H₃O₂. 7. NaOH. 8. Phenolphthalein. Procedure: Part A: 1. Add five drops
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Acetylsalicylic Acid (Aspirin) Synthesis Telow‚ AJV Sumicad‚ CJ‚ Tavanlar‚ EMMT‚ Chem 40.1‚ Institute of Chemistry‚ University of the Philippines Los Baños I. Introduction Organic synthesis is the process where a desired organic compound is constructed or prepared from commercially available materials. The objective of organic synthesis is to design the simplest synthetic routes to a molecule. Aspirin‚ also known as acetylsalicylic acid is as salicylate drug often used as analgesic
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