different nitrogens have been replaced by a hydrogen atom in these two variants. Later in the experiment‚ caffeine reacts with salicylic acid to form caffeine salicylate. The reaction is shown below. The nitrogen in the caffeine acts as a nucleophile‚ accepting the acidic proton from the salicylic acid. The Pka of the conjugate acid of caffeine is about 1.22‚ while the Pka of salicylic acid is 2.97. The reaction normally would be reagent favored‚ because the conjugate acid formed has a higher
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Introduction An electrophile is a reagent attracted to electrons and accepts an electron pair in order to bond to a nucleophile. Electrophiles will attack benzene and result in hydrogen substitution. However‚ this is not thermodynamically favoured because a sp3 hybridized carbon is generated‚ which disrupts the cyclic conjugation. In order to regenerate the aromatic ring‚ a proton is lost at the sp3 hybridized carbon. Thus‚ p-Nitroaniline can be prepared by means of electrophilic aromatic substitution
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Formaldehyde as a model protein crosslinking reagent. Understanding protein-protein interactions is becoming a vital study for application in the development of new age pharmaceuticals and utilization in diagnostic models. The overall aim is to gain an insight into the function and role of individual proteins with specific interest on how they react in cells‚ (Toews et al. 2008). The biopharma industry in Ireland is becoming a booming success for the economy therefore a complete understanding of
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Biochemistry Lecture Exam 1 Study Guide Chapter 1: Biochemistry: An Introduction I. Introduction a. Biochemistry: the study of molecules and chemical reactions of life b. Divided into 3 principal areas: 1. Structural chemistry of components of living matter & relationship of biological function to chemical structure 2. Metabolism – total chem reactions that occur in living matter; building & breaking down of molecules 3. Chemistry of processes & substances that store & transmit biological
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Grignard Synthesis of Tirphenylmethanol David Szuminsky Organic Chemistry Lab II Shaopeng Zhang Monday 1PM 2/10/14 & 2/24/14 - Abstract A sample of triphenylmethanol was prepared using Grignard synthesis techniques. Reflux was used in order to speed up the reaction and the final product was purified using recrystallization methods. The percent recovery and percent yield were 80.46% and 47.526%‚ respectively. A melting point range of 85-87oC was obtained from
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Wittig Reaction and Photoisomerization Abstract: For this laboratory experiment stilbene was produced through a Wittig reaction with benzyltriphenyl phosphonium and benzaldehyde producing a form of stilbene (Figure 1). This reaction favored a crude Z-Stilbene crystal product over its E counterpart. When Z-Stilbene underwent photoisomerization with iodine for 1 hour it reconfigured almost exclusively into its more stable counterpart E-Stilbene. The reaction produced very low yield of 6.3% due
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Radical Cations•+: Generation‚ Reactivity‚ Stability R A R A MacMillan Group Meeting 4-27-11 by Anthony Casarez Three Main Modes to Generate Radical Cations Chemical oxidation D A D A Photoinduced electron transfer (PET) h! 1) D A D A* D A 2) D A h! D* A D A Electrochemical oxidation (anodic oxidation) D Anode D Chemical Oxidation Stoichiometric oxidant: SET O N Bn H N Me O N Me t-Bu
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Preparation u Alcohols when heated in presence of H2SO4‚ H3PO4‚ P2O5‚ Al2O3 or BF3 undergo loss of water molecule with the formation of alkene. Conc. H2SO4 180oC H3PO4/P2O5 200oC Al2O3/BF3 350oC CH3-CH=CH2 + H2O CH3-CH2-CH2-OH CH3-CH=CH2 + H2O CH3-CH=CH2 + H2O u u Mechanism: In the first step OH group of the alcohol is protonated in a fast reversible reaction. Unlike OH group‚ protonated OH group is a good leaving group. Step 1: CH3 CH3-C-CH3 + H+ HO CH3 CH3-C-CH3 H2O+
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one atom contains a negative charge and another atom holds a positive charge. Both the positive and negative charges are contained on the same molecule. When an α-diazocarbonyl compound reacts with an aldehyde or ketone‚ the carbonyl acts as a nucleophile and will attack the electron-deficient carbene centre [7]. This will form an ylide. In the α-diazocarbonyl compound‚ the carbonyl carbon is negatively polarised due to the N2
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Multistep Synthesis of Tetraphenylcyclopentadienone Author: Instructor: Date work performed: 10.18.2012--10.25.2012 Date work submitted: 11.01.2012 Abstract: The aim of this experiment was to perform a multistep synthesis to form tetraphenylcyclopentadienone. The first step of the reactions was to synthesize benzoin from the condensation of benzaldehyde. A yield of 28.91% benzoin was obtained. The MP of benzoin was 127O-130O C and the IR spectra displayed a carbonyl peak at 3415 cm-1
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