Diels-Alder Synthesis of Exo-Norbornene-cis-5‚6-Dicarboxylic Anhydride for Organic Chemistry Laboratory Instruction Kyle Myers and Dr. James Roark University of Nebraska at Kearney‚ Department of Chemistry‚ Kearney‚ NE 68849 Abstract A technique for the Diels-Alder synthesis of endo-norbornene-cis-5‚6dicarboxylic anhydride and its stereoisomer‚ exo-norbornene-cis-5‚6-dicarboxylic anhydride‚ is explained. To prove that each stereoisomer was made in the experiment and to distinguish between the
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Aim Synthesis of Meso-1‚2-diphenyl-1‚2-ethanediol with focus on stereoselectivity Method Please refer to the CEM3005W practical manual for details on experimental procedure. Results and Analysis {Limiting reagent} Mass benzoin = 2.0050g (0.00945 mole) Mass sodium borohydride = 0.4059g (0.0107 mole) Mass compound A used to form compound B = 1.0647g Results Mass (g) moles Molecular formula Yield (%) Mp (pure) Compound A 1.7458 0.00815 C14H14O2 86.22 138-139 Compound C 0.4255
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Chirality of Ethyl-3-hydroxybutanoate Generated from a Biological Pathway Jake Zimny LaSalle University Philadelphia‚ PA 19141 Submitted February 10‚ 2006 Abstract: The reaction being studied is a reduction of a ketone into an alcohol with a chiral center. Because a biological agent‚ bakers ’ yeast‚ is being used to drive this reaction‚ the optical purity that results in the product is so stereo-selective that the major product‚ (+)‚ is formed for 89% of the product. Introduction: This
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Introduction‚ Discuss the nucleophilic substitution reactions that take place in this experiment. Explain how the difference in activation energies‚ and the differences in stability of the product can cause either a kinetic or a thermodynamic product to be produced. What type of reaction conditions or electrophiles will cause one or the other product to be made. What product do you think will be made in this reaction? Describe how NMR can be used to determine the structure of the product the relative
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8. Terfenedine is an amino diol that is the active ingredient in the antihistamine Seldane. Mass spectral analysis of terfenedine shows a molecular ion at m/z = 471 and a peak at m/z = 472 which is 35.5% the height of the molecular ion. Terfenedine is known to contain C‚ H‚ O and N. (a) Suggest five molecular formulas for terfenedine. (b) Terfenedine has an even number of carbons and contains nine double bonds and four rings. Based on this additional information‚ what is the formula for terfenedine
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NMR Project Sample 35 and 40 Chemical Engineering Chemical Analysis Aim The two samples are 35 and 40. Analytical techniques are vital in everyday science and so NMR procedure is an absolute essential to deduce compounds and chemical structures; this assignment requires the identification of two samples using an NMR software program. Background NMR spectroscopy is a well established method for structure determination of various organic molecules ranging from small molecules all the
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Dr. Probst 06/05/2012 The Physics of an MRI Machine There are many physical concepts used in a Magnetic Resonance Imaging‚ also known as MRI‚ machine. There are many physical concepts used when an MRI is taken of the body‚ such as; radio waves‚ resonance and pulse sequences‚ magnetic fields being produced and lastly‚ magnets. Radio waves much stronger than the magnetic field of the Earth are sent through the body which causes the nuclei in the body to move to a different position
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Epoxidation Reactions Lab Report 2 Abstract An oxygen atom is transferred from a peroxy acid to the carbon=carbon double bond thus forming an epoxide. Scheme 1. Oxone Epoxidation. Scheme 2. mCPBA Epoxidation. The percent yield for the Oxone epoxidation reaction was 65% yield and the mCPBA epoxidation reaction was 70% yield. Oxone is the greener alternative because using mCPBA is twice as expensive as Oxone and leaves behind the epoxide plus m-chlorobenzoic acid while Oxone creates non-toxic
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General Papers ARKIVOC 2006 (i) 109-118 Synthesis and primary antiviral activity evaluation of 3-hydrazono-5-nitro-2-indolinone derivatives Nalan Terzioğlu *a‚ Nilgün Karalı a‚ Aysel Gürsoy a‚ Christophe Pannecouque b‚ Pieter Leysen b‚ Jan Paeshuyse b‚ Johan Neyts b‚ and Erik De Clercq b a Istanbul University‚ Faculty of Pharmacy‚ Department of Pharmaceutical Chemistry‚ 34116‚ Istanbul‚ Turkey b Rega Institue of Medical Research‚ Katholieke Universiteit Leuven‚ B-3000 Leuven‚ Belgium E-mail:
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Experiment 1: Preparation of 1-Bromobutane and Reactivity of Alkyl Halides Objective: The purpose of this lab is to prepare 1-bromobutane from 1-butanol in an acid-catalyzed substitution reaction. While the reaction would be expected to occur as SN2 due to the primary nature of the substrate‚ because H2SO4 is used as a solvent‚ the conditions are very polar and the reaction can proceed via an SN1 reaction. The main objective is to obtain test results to determine the mechanism of the reaction
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