electrophile in the nitration reaction‚ will attack the benzene ring and produces the nitrobenzene ring. Resonance-stabilized arenium ion is created when the nucleophilic carbon pi bond on the acetanilide reacts with the nitronium ion. The aromaticity of the compound is lost in this important step. Water‚ acting as the Lewis base‚ removes a proton from the carbon bonded to the nitro group‚ an aromatic benzyl structure is created again: nitroacetanilide; thus ending the nitration reaction (1). Next
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Paracetamol - a curriculum resource Frank Ellis RSeC ROYAL SOCIETY OF CHEMISTRY Paracetamol - a curriculum resource Compiled by Frank E llis Edited by Colin Osborne and Maria Pack Designed by lmogen Bertin Published by the Royal Society of Chemistry Printed by the Royal Society of Chemistry Copyright 0 Royal Society of Chemistry 2002 Registered charity No. 207890 Apart from any fair dealing for the purposes of research or private study‚ or criticism or review‚ as permitted under
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an organic laboratory‚ to carry out syntheses that are discussed in the lecture course‚ and to familiarize you with the principles employed in identifying a simple organic compound. Occupational Health and Safety Notices The Elements 1. Nitration of acetanilide 2. Hydrolysis of p – nitroacetanilide and thin layer chromatography 3. Separation of a three – component mixture by extraction 4. Completion of experiments from day 1 to 4 5. NMR workshop 6. Sandmeyer Reaction: Preparation of p-chloronitrobenzene
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In this experiment‚ acetanilide‚ the crude product of acetylation of aniline and acetic anhydride‚ was used as the pure organic compound. Crude acetanilide underwent crystallization process using the preferred recrystallizing solvent‚ water. The crystallization process was when crude acetanilide was placed in hot water bath and was cooled after in an ice bath which would then yield to the formation of crystals of pure acetanilide. The percentage yield form the crude acetanilide was 94.59%. The percentage
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RECRYSTALLIZATION OF ACETANILIDE ABSTRACT Recrystallization is the primary method for purifying solid organic compounds through the differences in solubility at different temperatures. In this experiment‚ a suitable solvent was first determined. Acetanilide was produced by acetylation of aniline with acetic anhydride. The crude acetanilide was dissolved in a solvent in a heating water bath. The hot solution was filtered and the filtrate‚ cooled slowly in an ice bath as crystals started forming
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question by the Association for Safe Pharmaceuticals. Therefore‚ the lab must discover the accuracy of the ingredients listed on Panacetin’s label. The unknown in this experiment is presumed to be something similar to acetaminophen‚ such as acetanilide or phenacetin. Recrystallization and melting point temperature were used to help identify the unknown in Panacetin. Recrystallization removes impurities as a substance goes through physical transformations from a solid to a liquid and back to
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Purification of Acetanilide by Recrystallization Method Dupaya‚ Julian Victor M. Estacio‚ Jerwin Caesar A. Farnacio‚ Rebecca Ruth Gabito‚ Jose Luis F. Gallo‚ Cian Carlo M. Galvez‚ Joshua M. Group no.4‚ 2D-Medical Technology‚ Faculty of Pharmacy‚ University of Santo Tomas ABSTRACT Recrystallization is a method for purifying solid organic compounds. The process is dissolving the solid to be purified in a hot solvent and cooling the solution slowly‚ this allows impurities with different
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Recrystallization Abstract: Technical grade aniline was reacted with acetic anhydride to give acetanilide a dark brown color‚ due to the presence of impurities. Crystallization of the crude product from water was combined with decolorization with activated carbon‚ furnished pure acetanilide as white flakes‚ melting point 112-115°C‚ yield 70.3%. Experimental: 2 grams of technical grade aniline and 15ml water were placed in a 125ml Erlenmeyer flask. Then‚ 2.5ml of acetic anhydride was
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the weight and melting point of the final version of the sample. I began the lab with 1.5 grams of the impure acetanilide solute and ended the lab with 0.05 grams of pure acetanilide crystals. The percentage of pure acetanilide I recovered during this lab was 3.33%‚ which is lower than I expected. However‚ the low percentage shows that the impurities within the original impure acetanilide solute were removed. A number of factors could have caused the low yield of pure crystals. The melting
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compound. The methods used to achieve this objective were also hot vacuum filtration in order to remove suspended solid impurities‚ and isolating the pure acetanilide. In the next lab‚ percent recovered was obtained through weighing the acetanilide sample as well as comparing its melting point range. In this experiment‚ the sample‚ acetanilide was weighted to be 1.523 grams. The sample appeared to be a pale mixture of brown flakes before it was crushed into small flakes. When boiling the sample with
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