Diamorphine is an opioid produced over one hundred years ago by the acetylation of morphine. Diamorphine is twice as potent when compared to morphine‚ because it is a more lipophilic molecule‚ containing a partition coefficient of 280 (Suresh‚ 2013). The lipophilicity of diamorphine allows it to rapidly distribute across the blood-brain barrier‚ producing effects within seconds. Morphine cannot penetrate the blood brain barrier at that rate‚ because it contains two hydroxyl groupings within its structure
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Farbenfabriken vorm Fredrick Bayer and CO was the first to commercially sell Heroin in 1898. C. The reason heroin was able to become deeply rooted in the U.S. Body A. Re-synthesized because Scientist were searching for a non addictive substitute for morphine as a treatment
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growing up watching his mother’s doctor make house calls and treating her illness with morphine. Dr. Shipman’s mom died a slow and painful death of cancer. (Morris‚ 2001) On the night of her death‚ Dr. Shipman ran miles through the streets of Nottingham in the pouring rain‚ tears streaming down his face. (Morris‚ 2001) Dr. Shipman pursues becoming a doctor; nevertheless‚ he was fascinated with the effects of the morphine when he would see how high his mother‚ would be. Who knows what was going through
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LAURELS OPTIONS AT THIS STAGE? (Retrieved from: http://www.huffingtonpost.co.uk/2013/01/22/cancer-non-hodgkin-lymphoma-patient-speed_n_2526486.html) TYPES OF PHARMACOLOGICAL PAIN RELIEF Inhalation Analgesia (Nitrous Oxide) Opioids (Pethidine/Morphine) Local Anesthetics Regional Anesthetics (Epidural/Spinal) INHALATION ANALGESIA NITROUS OXIDE (N 2 O) Nitrous Oxide is commonly known as “laughing gas” or “gas and air” It is a mixture of 50% Nitrous Oxide and 50% Oxygen Acts as a relaxant
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agent. 120mg of codeine administered SC (subcutaneously‚ injected under the skin) provides pain relief equal to 10mg of morphine administered by the same route. Doses used to relieve cough or diarrhea range from 5mg to 30mg. Codeine is absorbed quickly from the GI tract and it’s first pass through the liver results in very little loss of the drug. This contrasts with morphine in which over 90% of the drug is metabolized in the first pass through the liver resulting in a considerable loss of potency
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Endorphins ("endogenous morphine") are endogenous opioid peptides that function as neurotransmitters.[1] They are produced by the pituitary gland and the hypothalamus in vertebrates during exercise‚[2] excitement‚ pain‚ consumption of spicy food‚ love and orgasm‚[3][4] and they resemble the opiates in their abilities to produce analgesia and a feeling of well-being. The term implies a pharmacological activity (analogous to the activity of the corticosteroid category of biochemicals) as opposed to
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unruly and disturbing that their father was okay with this behavior. Jem and scout heard criticism from a lot of people but the person who made it sting the most lived two houses down from them‚ Mrs. Dubose. Mrs. Dubose is an old‚ rude hag addicted to morphine and in this book is a symbol for the reality of things. This mean old witch is racist‚ very rude and knows how to make her words sting. Mrs. Dubose’s full name is Henry Lafayette Dubose‚ a boy’s name‚ which is more than ironic when she makes fun
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Heroin 1.The correct chemical name for heroin is‚ Diacetylmorphine or Diamorphine. Heroin falls into the depressants category. Depressants slow down the messages between the brain and the body by slowing down the central nervous system. According to National Institute on Drug Abuse (NIDA) and Drug Enforcement Agency (DEA)‚ heroin is a schedule I substance. Since it is a schedule I substance‚ it means that it is more likely to be abused. 2. Heroin has a lot of slang terms. Some nicknames are‚ H
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The patient arrived with a systolic blood pressure in the low 60’s and was administered three liters IVF bolus before getting the systolic blood pressure to 90 mm Hg. Again‚ the patient was administered IV morphine 8mg for pain and she subsequently became bradycardic and complained of feeling lightheaded. Atropine was ordered on standby and aggressive IVF hydration was continued. A CT scan of the abdomen and pelvis was performed and demonstrated a blocked
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is Mrs Dubose? Mrs Dubose was an old‚ bad-tempered‚ wheel-chair bound woman who lives with her maid‚ Jessie‚ two doors down from the Finches‚ sits on her porch and shouts out rude comments to the children whenever they pass her house. She was a morphine addict and as the novel progresses she attempts to break off her compulsion. 2. How does she fit into Maycomb society? Nobody in Maycomb really liked Mrs Dubose. Just like the Mockingbird‚ she was not what people thought she was supposed
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