Lessons from Biological Membranes‚ Liposomes for Drug Delivery Advantages of Pectin Coating of Liposomes for Drug Delivery Liposomes are miniscule vesicles composed of hydrophilic and hydrophobic ends used for many processes in the body including delivery of pharmaceuticals‚ more often known as medication. For the delivery of drugs that are hydrophilic and hydrophobic‚ the liposome is used (Alund et al.‚ 2013). Prior to the drug delivery process‚ these liposomes are coated with a gel-like substance
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harsh requirements on the taste-masking technology of the fast dissolving oral film.How to mask the terrible taste of the active pharmaceutical ingredient is also a key issue to be solved. In view of the above problems‚ suspension intermediate and liposome intermediate were prepared respectively for the preparation of two kinds of fast dissolving oral
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certain conditions by delivering drugs or nutrients to the body with the help of liposomes. Liposomes are artificially engineered vesicles within a lipid bilayer. (Lee‚ 2006) There are various methods by which liposomes can deliver the needed substances. One of these ways is to create a PH gradient between the solution and the liposome. As the pH neutralizes the drug is able to diffuse across the membrane into the liposome and will eventually diffuse into the cells once it is within the body. (Bertrand
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Liposomes Definition and background10 Liposomes were discovered in the early 1960’s and subsequently studied as cell membrane models. They have since gained recognition in the field of drug delivery. Liposomes are spherical vesicles which can be thought of as a hollow sphere they are composed of a bilayer membrane which entraps an aqueous core. The particle size of liposomes ranges from 20 nm to 10 μm in diameter. Liposomes vary in charge and in size depending on their manufacturing protocol
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Biosensors and Bioelectronics 21 (2005) 384–388 Short communication Fluorescence detection of enzymatic activity within a liposome based nano-biosensor Vicky Vamvakakia ‚ Didier Fournierb ‚ Nikos A. Chaniotakisa‚∗ a Laboratory of Analytical Chemistry‚ Department of Chemistry‚ Knossou Avenue‚ University of Crete‚ 71409 Iraklion‚ Crete‚ Greece b IPBS‚ 205 Route de Narbonne‚ 31077 Toulouse‚ France Received 26 July 2004; received in revised form 22 September 2004; accepted 25 October 2004
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properties when formulated in the colloidal state. Another important pharmaceutical application of colloid is their use as drug delivery system. The most often used colloid type drug delivery systems include hydrogels‚ microspheres‚ microemulsions‚ liposomes‚ micelles‚ nanoparticles and nanocrystals. Here we mention the main characteristics of each colloidal delivery system. Hydrogels: Hydrogel is a colloidal gel in which water is the dispersion medium. It (also called aquagel) is a network of polymer
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MINIREVIEW Folate Receptor-Mediated Drug Targeting: From Therapeutics to Diagnostics ANDREW R. HILGENBRINK‚ PHILIP S. LOW Department of Chemistry‚ Purdue University‚ West Lafayette‚ Indiana 47907 Received 25 May 2005; accepted 27 June 2005 Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jps.20457 ABSTRACT: Folate targeted drug delivery has emerged as an alternative therapy for the treatment and imaging of many cancers and inflammatory diseases. Due to its
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Liposomes of specific composition were prepared using a standard protocol. Briefly‚ Overnight hydration of lipid thin film obtained by high pressure vacuum evaporation of lipid mixture was done using Buffer A (Hepes-10 mM‚ KCL-150 mM‚ and 2mM EDTA‚ pH 7.4). This was followed by short periods of shaking and bath sonication for better retrieval of the lipids. Vesicles were generated from this initial mixture by freeze-thawing (10 cycles) and bath sonication for 20 min. 100 nm liposomes were produced
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Vaccines represent one of the great achievements in public health. A turning point in the war against pathogenic infection occurred over 200 years ago when Edward Jenner used cowpox to elicit protective immune responses against a devastating outbreak of smallpox. Since then‚ the use of safe and effective vaccines to prevent infection has become a fundamental aspect of modern medicine. While many vaccination campaigns have been successful‚ the constant emergence‚ and re-emergence‚ of pathogens challenges
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replace mutated‚ improperly functioning genes with regular DNA. There are several gene therapy methods‚ most of which involve using a vector to transport the corrected gene into targeted cells. Retroviruses‚ adenoviruses‚ adeno associated viruses and liposomes are commonly used as vectors. Naked DNA (DNA without a vector) has also been used in gene therapy. Recently‚ gene therapy has been used as a treatment for deadly genetic conditions such as cystic fibrosis. Even though gene therapy has a promising
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