Title: Reaction of Iodoethane with Sodium Saccharin- Ambient Nucleophile Dates Performed: February 21 + 28‚ 2013 Date Submitted: March 14‚ 2013 Abstract: The product ratio of N-ethylsaccharin to O-ethylsaccharin that occurred due to alkylation with iodoethane at 80 oC was determined to be 81.5% to 18.5%‚ respectively‚ based on an analysis of the 1H NMR spectrum that was collected. The melting point range of 87.8-94.7 oC also indicated that the mixture was largely composed of N-ethylsaccharin
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Discussion: In this experiment‚ we alkylate sodium saccharin to N-ethylsaccharin with iodoethane in an aprotic solvent N‚N dimethylformamide. Nucleophiles in this experiment will react better in an aprotic solvent. Aprotic solvents have dipoles due to its polar bonds but they do not have H atoms that can be donated into a H-bond. The anions which are the O- and N- of sodium saccharin are not solvated therefore are “naked” and the reaction is not inhibited and preceded in an accelerated rate.
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Saccharin is one of the most disputed sugar substitutes in the United States today. Since 1977‚ it has been regarded as potentially carcinogenic ("Saccharin"‚ 1999). The sweetness of saccharin compared to sugarcane is utterly amazing. When measured up to sugarcane‚ saccharin is 550 times as sweet in its pure state. Also‚ it is estimated to have a sweetening power of 375 times that of sugar ("Saccharin"‚ 2000)! This drug may be amazing‚ but some people say that it causes a dangerous disease‚
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Introduction The purpose to of this experiment is to carry out the alkylation of sodium saccharin with iodo-ethane and analyze the product mixture to determine the structure of the major product. Sodium saccharin is made from the base catalyzed de protonation of saccharin. This nucleophilic reaction is special because the nucleophilic atom can be oxygen or nitrogen and the leaving group is iodide ion. The solvent used in this reaction is very important for determining the rate of nucleophilic
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SODIUM gSodium is a chemical element with the symbol Na (from Latin: natrium) and atomic number 11. It is a soft‚ silver-white‚ highly reactive metal and is a member of the alkali metals; its only stable isotope is 23Na. The free metal does not occur in nature‚ but instead must be prepared from its compounds; it was first isolated by Humphry Davy in 1807 by the electrolysis of sodium hydroxide. Sodium is the sixth most abundant element in the Earth’s crust‚ and exists in numerous minerals such
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Sodium From Wikipedia‚ the free encyclopedia This article is about the chemical element. For the PlayStation Home game‚ see Sodium (PlayStation Home). For the racehorse‚ seeSodium (horse). "Natrium" redirects here. For the town in West Virginia‚ see Natrium‚ West Virginia. Sodium 11Na
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Sodium is a mineral that is present only in small quantities in most natural foods‚ but salt is added‚ often in large amounts‚ in food processing and by cooks to enhance flavor. Sodium is the predominant ion in extra cellular fluid. Sodium (Na) is the predominant cation in extra cellular fluid and its concentration is under tight homeostatic control. Excess dietary sodium is excreted in the urine. The kidney very efficiently reabsorbs the mineral when intakes are low or losses are excessive. Sodium
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Sodium chloride‚ also known as salt‚ common salt‚ table salt‚ or halite‚ is an ionic compound with the formula NaCl. Sodium chloride is the salt most responsible for the salinity of the ocean and of the extracellular fluid of many multicellular organisms. As the major ingredient in edible salt‚ it is commonly used as a condiment and food preservative. [edit] Properties Thermal conductivity of pure NaCl as a function of temperature has a maximum of 2.03 W/(cm K) at 8 K and decreases to 0.069 at 314
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Sodium hydroxide‚ also known as caustic soda‚[2][3] or lye‚ is an inorganic compound with the chemical formula NaOH (also written as NaHO). It is a white solid‚ and is a highly caustic metallic base and alkali salt. It is available in pellets‚ flakes‚ granules‚ and as a 50% saturated solution.[citation needed] Sodium hydroxide is soluble in water‚ ethanol and methanol. This alkali is deliquescent and readily absorbs moisture and carbon dioxide in air. Sodium hydroxide is used in many industries
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SODIUM DISORDERS * Identify specific types of hyponatremia and hypernatremia using diagnostic criteria and assessment questions * Hyponatremia * Mild: 125-130 * Nausea‚ Malaise * Moderate: 115-125 * HA‚ Lethargy‚ Restlessness‚ Disorientation * Severe: <115 * Seizures‚ Coma‚ Resp/Brainstem damage * Hypernatremia * Mild: 145-160 * Asymptomatic * Moderate: 160-180
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