and Tylenol). These compositions were determined by using the method of thin-layer chromatography (TLC) of the four over-the-counter drugs‚ which were then compared to four different components of drugs (acetaminophen‚ aspirin‚ caffeine‚ and salicylamide). Experiment Scheme1: Figure 1. Structure formulas1 Under an open flame in the hood‚ 12 capillary micropipettes were made. Two silica TLC plates were obtained‚ along with a development chamber. Each plate was prepared
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plate‚ a reference plate‚ we will spot five standard compounds . In addition‚ a standard reference mixture containing four of these same compounds will be spotted. In this experiment we will not be using Ibuprofen because it would overlap with salicylamide after the plate is developed.On the second plate (the sample plate)‚ you will spot Naproxen sodium as an additional standard and four commercial analgesic preparations in order to determine their composition. Two methods of visualization will
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Travels (cm) | Fluorescence? | I2 Staining Appearance | Acetaminophen | 48 | 150 | No | Dark Yellow | Aspirin | 86 | 150 | No | Not Significant | Caffeine | 14 | 150 | No | Not Significant | Ibuprofen | 92 | 148 | No | Not Significant | Salicylamide | 81 | 148 | Yes |
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compare unknown in TLC Silica Gel Plates- TLC plates. Stationary phase Elemental Iodine- used to accentuate the spots on the TLC plates so we can measure Rf. Asprin(Acetylsalicylic acid)- First compound used on TLC plate to compare the unknown. Salicylamide(o-hydroxybenzamide)-Second compound used on TLC plate to compare unknown. Caffine(1‚3‚7-Trimethylxanthine)-Third compound used on TLC plates to compare unknown. Acetone- Solvent A used in paper chromatography. Ethanol- Solvent B used in paper
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4cm = .392 Rf4 Ibuprofen 2.9cm/7.4cm = .392 Rf5 Salicylamide 5.0cm/7.4cm = .676 Rf6 Caffeine 1.0cm/7.4cm = .135 Trial 2: Rf1 Unknown 5.0cm/7.4cm = .676 Rf1 Unknown 5.0cm/7.4cm = .676 Rf2 Aspirin 5.2cm/7.4cm = .703 Rf3 Acetaminophen 3.3cm/7.4cm = .446 Rf4 Ibuprofen 4.9cm/7.4cm = .662 Rf5 Salicylamide 5.1cm/7.4cm = .689 Rf6 Caffeine 0.9cm/7
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percent of the population was affected with IDD‚ according to the goiter prevalence survey done by Food and Nutrition Research Institute (FNRI).Selected ReferencesDepartment of Health. Guidelines for Salt Iodination for IDD Elimination Training Modules‚ 1994. Mannar‚ V. Salt Iodination-Part 2: Iodination Techniques. IDD Newsletter‚ 1988. Suwanik‚ R.‚ et al. Simple Technology Provides Effective IDD Control at the Village Level. IDD Newsletter‚ 1989. | Mechanical Chalkdust Dispenser | AbstractThe
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Objective The purpose of this experiment is to identify an unknown proprietary drug using thin-layer chromatography. The unknown’s behavior in thin-layer chromatography will be compared with that of its possible component analgesics. The possible unknowns and their analgesic ingredients will be Anacin (aspirin‚ caffeine)‚ Excedrin (acetaminophen‚ caffeine‚ aspirin)‚ Motrin (ibuprofen)‚ and Tylenol (acetaminophen). Introduction Thin-layer Chromatography(TLC) was the method used to figure out and
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system were iodinated with an iodic acid-iodine mixture [37]. Bromination at the same positions was performed via N-bromosuccinamide (NBS) [38]. 8-Palmitoyl-1‚ 3‚ 5‚ 7-tetramethyl-2‚ 6 diiodo-4-bora‚ 3a‚ 4a-diaza-s-indacene was obtained by the iodination of 8-palmitoyl-1‚ 3‚ 5‚
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tract OT 16. _______ is the term for the constellation of defects resulting from untreated neonatal hypothyroidism. cretinism 17. _______ may have synthetic hormones bind to them hormone receptors 18. _______ stimulates both I- uptake and iodination of tyrosine residues on thyroglobulin TSH 19. _______ stimulates contraction of the uterus and ejection (let-down) of milk from the breasts oxytocin
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Experiment A1: Kinetics of the Reaction between Acetone and Iodine The key aim of this experiment was to determine the rate equation for the acid-catalysed iodination of acetone and to hence consider the insinuations of the mechanism of the rate equation obtained. The stoichiometric equation for the reaction between iodine and acetone is below‚ followed by the rate equation (where x‚y‚z and k are the values to be obtained): I2 + CH3COCH3 CH3COCH2I + HI -d[I2]/dt = k [I2]x [CH3COCH3]y [H+]z
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