corrosive‚ harmful if inhaled‚ flammable and can cause burns (handle in fume hood) Gloves are recommended to avoid chemical contact with skin Reaction Scheme: Conversion of acetanilide to p-bromoacetanilide Procedure: To a 125 mL Erlenmeyer flask containing a mixture of 95% ethanol (6 mL) and acetic acid (5 mL)‚ dissolve acetanilide (7.4 mmol) and sodium bromide (1.8 g). Place the reaction flask in an ice bath (at least 5oC) for 5 minutes (keep this reaction in the hood). Add sodium hypochlorite (8
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different substituted benzenes towards bromination will be determined‚ where bromine is dissolved in acetic acid. Materials and apparatus Test solutions: 0.2 M solutions in ethyl acetate: Benzene‚ chlorobenzene‚ phenol‚ nitrophenol‚ aniline and acetanilide. Measuring pipettes (5 mL) micro test tubes 0.05 M Br2 in 90% CH3COOH Pasteur pipettes 0.05 M Br2 in cyclohexane II. Schematic Diagram of the Procedure Relative Rates of Bromination Add 2 drops of 0
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In the first part of this experiment acetic anhydride was used to prepare acetanilide which could then be readily brominated to form a mono-brominated product‚ with the bromine positioned at either the ortho‚ meta or para position on the aromatic ring. Acetic anhydride is very reactive towards nucleophiles and this reactivity is the result of the difference in electronegativities of the carbon and oxygen atoms that are bonded in acetic anhydride. This difference in electronegativities causes one
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the procedure outlined in Appendix A of the Lab Manual‚ approximately equal samples of p-Nitrophenol and acetanilide‚ which are known to have the same melting range of 113-114 degrees Celcius‚ were taken and inserted into the melting point apparatus. The melting points of the compounds were noted and found to be very similar. Next‚ approximately equal amounts of p-Nitrophenol and acetanilide were mixed on a clean watch glass. A sample of the mixture was placed in the Mel-temp apparatus as before
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Compounds by Solvent Extraction Introduction The purpose of this experiment was to use solvent extraction techniques in order to separate a mixture consisting of a carboxylic acid (p-toulic acid)‚ a phenol (p-tert-butylphenol)‚ and a neutral compound (acetanilide). Extraction is the process of selectively dissolving one or more of the compounds of a mixture into an appropriate solvent‚ the solution that contains these dissolved compounds is called an extract (Manion‚ 2004). Impurities that are present
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Mapua Institute of Technology Organic Chemistry Laboratory 2 Final Report Factors Affecting the Relative Rates of Electrophilic Aromatic Substitution Reaction Justiniano‚ Priscilla Raiza N. School of Chemical Engineering and Chemistry‚ Mapua Institute of Technology‚ Intramuros‚ Manila‚ Philippines Experiment No.1‚ Submitted on August 6‚ 2011 at N402. Abstract EXPERIMENT NUMBER ONE IS ALL ABOUT THE ELECTROPHILIC SUBSTITUTION OF AROMATIC COMPOUNDS. AROMATIC COMPOUNDS ARE THOSE ORGANIC
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Experiment 3 Objectives Separation by Solvent Extraction To separate a mixture consisting of a carboxylic acid and a neutral compound by using solvent extraction techniques. Introduction Frequently‚ organic chemists must separate an organic compound from a mixture of compounds‚ often derived from natural sources or products of synthetic reactions. One technique used to separate the mixture compounds is called extraction. Extraction is a process
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(2‚4‚6 tribromoaniline‚ mp of 108-110 C) respectively. Discussion and Conclusions: Interpreting these results have concluded that relative reactivity of these three anilines in order of most reactive to least reactive go; Aniline > Anisole > Acetanilide. Aniline‚ has an NH2 ‚ the most active substituent ‚ and adds to any ortho/para position available on the ring. This data is confirmed with the product obtained‚ (2‚4‚6 tribromoaniline‚ mp of 108-110 C). As for anisole‚ it has a strongly activating
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: Paracetamol (325mg)‚ a non-opioid and non-salicylate analgesic. It is indicated for the treatment of moderate to severe pain. Name Acetaminophen Drug Type Small Molecule Approved Description Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic‚ but may cause liver‚ blood cell‚ and kidney damage. Synonyms Acetaminofen Paracetamolo Paracetamol Brand Taken Crocin - Remidex Pharma Calpol -
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composed of sucrose (10%)‚ aspirin (40%)‚ and Tylenol (50%). Although this information is reported‚ the true composition of Panacetin is questionable. While sucrose and aspirin are present in Panacetin‚ Tylenol may be replaced by an unknown component (acetanilide or phenacetin). Separation of the components of a sample of Panacetin may prove valuable in identification of the unknown component‚ as well as the true percent composition of each component of Panacetin. This experiment involves two parts‚ covering
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