The Grignard Reaction Abstract Through the use of the Grignard reaction‚ a carbon-carbon bond was formed‚ thereby resulting in the formation of triphenylmethanol from phenyl magnesium bromide and benzophenone. A recrystallization was performed to purify the Grignard product by dissolving the product in methanol. From here‚ a melting point range of 147.0 °C to 150.8 °C was obtained. The purified product yielded an IR spectrum with major peaks of 3471.82 cm-1‚ 3060.90 cm-1‚ 1597.38 cm-1‚ and 1489
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Preparation Of Triphenylmethanol Objectives 1. To study the preparation of triphenylmethanol using through Gridnard reaction 2. To study the operations of anhydrous reaction‚ water vapor distillation. Principles Alcohol is widely used in organic chemistry‚ not only as solute but also as intermediate to synthesize halide‚ alkene‚ ether‚ aldehyde and ketone etc. In laboratory‚ an important method of synthesizing alcohol is though the addition reaction of Gridnard reagent and carbonyl compound‚ whereas
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Grignard Reaction: Synthesis of Triphenylmethanol Hai Liu TA: Ara Austin Mondays: 11:30-2:20 Abstract: In this experiment‚ phenylmagnesium bromide‚ a Grignard reagent was synthesized from bromobenzene and magnesium strips in a diethyl ether solvent. The Grignard reagent was then converted to triphenylmethanol‚ a tertiary alcohol with HCl. The reaction for phenylmagnesium bromide was: The reaction for Grignard to triphenylmethanol was: In the formation of the Grignard reagent
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Introduction In a Grignard reaction‚ a Grignard reagent (R–MgX) adds to the carbonyl group in an aldehyde or ketone to form an alcohol (Figure 1). The reaction of a Grignard reagent with formaldehyde can be to synthesize a primary alcohol‚ with any other aldehyde can be used to synthesize a secondary alcohol‚ while the reaction with ketone is useful in the synthesis of a tertiary alcohol. Figure 1. General reaction mechanism of a Grignard Reaction The preparation of the Grignard reagent involves
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procedures were divided into two categories. First the formation of phenylmagnesium bromide‚ and second the reaction of the phenylmagnesium bromide with the carbonyl compound. However‚ before any of this could be done‚ the refluxing apparatus for the Grignard reaction was to be flame dried until no moisture remained inside because any water would cause the reagent to decompose and an alkane to form. The reaction would subsequently fail. Drierite was placed inside a plastic drying tube as a drying agent
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Experiment C. Aim: To protect one of two carbonyl groups (C1) in order to allow the other to react twice with a Grignard followed by removal of the protecting group by acid hydrolysis to give final product (C2). Method: Ethyl acetoacetate (30.03g)‚ ethylene glycol (15.01g) and toluene-p-sulphonic acid (0.13g) were added to a 250 cm3 round bottomed flask‚ containing a stirrer bar and toluene (100 cm3)‚ fitted with a condenser and dean-stark head. Solution was heated strongly under reflux using
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wavelength Percentage concentration (methanol: water) Peak H value (height equivalent to a theoretical plate) (mm) 230nm 80:20 Phenol 0.0373 Benzophenone 0.0196 Naphthalene 0.0164 235nm 80:20 Phenol 0.0327 Benzophenone 0.0203 Naphthalene 0.0147 260nm 80:20 Phenol 0.0318 Benzophenone 0.0202 Naphthalene 0.0146 Figure 11: table for the height equivalent of the theoretical plates. It can be observed that the H values or height equivalent to a theoretical plate for phenol at the three wavelengths
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Objective: The purpose of this experiment was to prepare the Grignard reagent methylmagnesium iodide and react it with benzoin to form the 3o alcohol 1‚2-diphenyl-1‚2-propanediol‚ through an addition reaction pathway. Introduction: Grignard reagents are alkyl or aryl-magnesium halides that act as the nucleophile in Grignard reactions‚ where ketones are reacted with the reagent‚ then treated with acid to produce an alcohol. In the case of this experiment‚ methylmagnesium iodide was created
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Experiment Date: 3/12/2012 Photochemistry: Photoreduction of benzophenone and rearrangement to benzpinacolone Abstract: In this experiment Benzpinacolone was synthesized in a process that contained two steps. First the photoreduction of benzophenone in 2-propanol‚ which was done by placing the flask under sunlightfor the absorption of the UV rays to carry out the reaction. Then the second part was the dehydration of benzpinacol to benzpinacolone‚ where the benzpinacol product was converted
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different melting point expected for the pure compound and a broadening of the melting point range. Such an observation would indicates that a compound is impure. In experiment 3.2‚ 0.120g sample of benzophenone was obtained from stock and crushed into a fine powder. Two samples of the benzophenone were loaded into a capillary tube. The capillary tubes were then individually placed in a Mel-Temp apparatus where they were gradually heated at a steady rate of 1º/minute. The melting rate was manually
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