Synthesis of 1-Bromobutane from 1-Butanol Reference: Discovering Organic Chemistry in the Laboratory; John R. Ganson Ph. D‚ Revised 2011 by Alfredo Mellace Ph. D www.Aldrich.com Purpose: To synthesize 1-bromobutane from 1-butanol via SN2 reaction. Alcohols are converted into the alkyl halides adding an aqueous solution sodium bromide. The sulfuric acid acts as a catalyst in converting the OH functional group of butanol‚ to a better leaving group. In order for this reaction to synthesis 1-Bromobutane
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Isoamyl Acetate Synthesis through Fischer Reaction Lesaca‚ Anna*‚ Lopez‚ Maria Flor‚ Lu‚ Ricardo‚ Magdurulan‚ Tricia 2Biology6‚ Department of Biology‚ College of Science‚ UST‚ Manila annalesaca@yahoo.com Abstract Esters are a type of functional group that causes distinguishable flavors or odors of some fruits. It can be synthesized by Fischer reaction‚ which is an acid-catalyzed reaction of an alcohol and carboxylic acid. One of the esters known for its characteristic banana flavor is the isoamyl
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CONTRIBUTION T HE O RCAXIC FROM CHEMICAL RESEARCH SECTION‚ LEDERLE LABORATORIES v r s r o x ‚ MERICAN VASAMID U~ A C R Co.‚ PBARLIVER‚X. Y . ] &Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1 BY GEORGEv. ANDERSON i A ND FRANCIS. C.4LLAHAN M R ECEIVED NOVEMBER 1959 30‚ T he s ynthesis of t-but)-1 esters of amino acids and peptides and their use in peptide synthesis is described. T h e most convenient method was the acid-catalyzed reaction of isobutylene
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Synthesis of Phenacetin from para-Acetamidophenol Aims: To determine how phenacetin from acetamidophenol (known as paracetamol) is synthesized using Sodium Ethoxide Iodine‚ which is the Williamson Ether synthesis. Experimental: Sodium metal was patted dry to remove any oil and was cat into small pieces. A dry 100cm3 round bottom flask was placed on a cork ring‚ on a balance and tarred sodium metal (0.6g) was placed into the flask. The flask was then attached to the dry reflux condenser
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becoming more and more acidic by everyday pollution from houses‚ factories‚ cars‚ and etc. This is the concept of acid rain‚ which according to EPA.gov is a broad term referring to a mixture of wet and dry deposition from the atmosphere containing higher than normal amounts of nitric and sulfuric acids. Acid rain isn’t just rain‚ its forms like hail or snow‚ which is wet deposition‚ and smoke or dust‚ which is dry deposition. The effects of acid rain are quite terrifying bringing all types of problems
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The C-O-C bond angle is 111o‚ slightly higher than the H-O-H bond angle in water because of the stronger electron repulsion between the bulky alkyl groups. Preparation of Ethers: 1. Preparation of symmetrical ethers from alcohols H2SO4 R O R + H2O 2ROH 2. Williamson Ether Synthesis R O Na - - + + + R’X R O R’ + NaX Ar O Na + RX Ar O R + NaX Involves a nucleophilic substitution reaction. Halide ion is displaced by the alkoxide or phenoxide ion. Gives best results
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Acid Base Titration bre’ana March 1‚ 2013 Purpose: The purpose of this experiment is to determine the concentration of a solution of NaOH by titration with a standard solution of HCl. It was also the purpose to determine the concentration of a sample of white vinegar by titration with a standard solution of NaOH. Introduction: Using the method of titration is how the experiment gets to the conclusion of the concentration of a solution. When doing this experiment‚ measurement is very important
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goals of this experiment are to determine if the products derived from amide synthesis and Williamson Ether Synthesis are identical‚ and if one of the synthetic routes is more advantageous than the other. In Part 1‚ an attempt to synthesize acteophenetidin crystals by amide synthesis was made. We began by removing the colored impurities from the p-Phenetidine (reddish-brown) by placing 2g of the sample in 38 mL of hydrochloric acid and heating the solution to boiling point. Upon reaching just below
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the same time its nonpolar‚ being that Silica gel in TLC 2 was polar and the solvent ethyl acetate-hexane is non-polar it moved relatively with the solvent. The stationary phase in TLC 3‚ alumina is non polar and the solvent ethyl acetate is polar so from the ideal that polar does not attract non-polar benzophenone stick stronger to alumina non-polar rather than moving up with polar solvent ethyl acetate as it did in tlc2. 6. Ethyl acetate is polar and Ethyl acetate- hexane is nonpolar‚ use of polarity
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An Unknown Amino Acid From Titration Abstract Experiment 11 used a titration curve to determine the identity of an unknown amino acid. The initial pH of the solution was 1.96‚ and the pKa’s found experimentally were 2.0‚ 4.0‚ and 9.85. The accepted pKa values were found to be 2.10‚ 4.07‚ and 9.47. The molecular weight was calculated to be 176.3 while the accepted value was found to be 183.5. The identity of the unknown amino acid was established to be glutamic acid‚ hydrochloride. Introduction
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