Megan Wierzbowski Organic II Laboratory Wed. 11-1:50 Title: Grignard Reaction with a Ketone: Triphenylmethanol Part 1 Objective: The goal of this experiment is to learn to make Grignard reagents. The reactions of the Grignard reagents with ketones form tertiary alcohols. These reagents are highly air- and moisture-sensitive materials. We will observe the formation of the Grignard reagents‚ which magnesium metal is transformed into organometallic salts. Experimental Procedure:
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The Grignard Synthesis of Triphenylmethanol Organic Chemistry Lab II March 19‚ 2012 Abstract The purpose of this experiment was to synthesize the Grignard reagent‚ phenyl magnesium bromide‚ and then use the manufactured Grignard reagent to synthesize the alcohol‚ triphenylmethanol‚ by reacting with benzophenone and protonation by H3O+. The triphenylmethanol was purified by recrystallization. The melting point‚ Infrared Spectroscopy‚ 13C NMR‚ and 1H NMR were used to characterize and confirm
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Grignard Synthesis of Triphenylmethanol from Benzophenone Purpose: The purpose of this experiment was to synthesize the tertiary alcohol triphenylmethanol from a Grignard reagent‚ phenyl magnesium bromide. The Grignard reagent was synthesized from bromobenzene and magnesium and then reacted with benzophenone to produce triphenylmethanol. It was important that water be excluded from the reaction‚ in order to prevent the formation of benzene. The reaction of phenyl magnesium bromide and benzophenone
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on the aromatic aldehyde affect the E/Z ratio of products that form. In this experiment‚ a nitro group was used as the substituent in the ortho‚ meta and para positions‚ with benzaldehyde as the control. Each of the four aldehydes reacted with (carbethoxymethylene) triphenylphosphorane to produce ethyl cinnamate‚ ethyl-3-(2-nitrophenyl)acrylate‚ ethyl-3-(3-nitrophenyl)acrylate‚ and ethyl-3-(4-nitrophenyl)acrylate. The prediction was the closer the substituent was to the aldehyde‚ the greater the
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Objective: The purpose of this experiment was to prepare the Grignard reagent methylmagnesium iodide and react it with benzoin to form the 3o alcohol 1‚2-diphenyl-1‚2-propanediol‚ through an addition reaction pathway. Introduction: Grignard reagents are alkyl or aryl-magnesium halides that act as the nucleophile in Grignard reactions‚ where ketones are reacted with the reagent‚ then treated with acid to produce an alcohol. In the case of this experiment‚ methylmagnesium iodide was created
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Flavoring Agents made from Aldehydes and Ketones Peter Konn Mountain State University Chemistry 302 7/31/12 Abstract This paper looks to delve into the chemistry behind ketones and aldehydes as well as related compounds. The endeavor involved looking into the way their bonding influences how they react. It also considers the simple physical properties of these compounds including their reaction with other compounds‚ chemical structures and formulas. The paper also looked to
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State and explain principles governing the physical and chemical properties of aldehydes‚ ketones‚ carboxylic acid‚ carboxylic acid derivatives and amines. Write‚ explain and solve problems related the reaction mechanisms for nucleophilic addtition of carbonyl compounds and nucleophilic acyl substitution of carboxylic acids and their derivatives. Develop synthetic methods for preparations of various types of aldehydes‚ ketones‚ carboxylic acids‚ carboxylic acid derivatives and amines. Plan‚ conduct
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Lewis acid and Lewis base. Orbital hybridization: sp3‚ sp2‚ sp. Conjugated double bonds and resonance 2. Classification of organic compounds Nomenclature: homologues series‚ alkanes‚ cycloalkanes‚ alkene‚ alkynes‚ alkyl halides‚ alcohols‚ amines‚ aldehydes‚ ketones and carboxylic 4 acids and their derivatives. 3. Stereochemistry Conformations of alkanes and cycloalkanes. Isomerism and optical activity. Structural isomers and stereoisomers. Geometrical isomers: (E) and (Z) systems. Enantiomers and
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August 24‚ 2012; Date Submitted: September 19‚ 2012 Results and Discussion Aldehydes and ketones both contain the carbonyl group – a group in which a carbon atom has a double bond to oxygen. The carbonyl group in aldehydes is bonded to at least one hydrogen atom‚ and in ketones it is bonded to two carbon atoms. The general formula for an aldehyde is And the general formula for a ketone is Aldehydes and ketones have a trigonal planar arrangement of groups around the carbonyl carbon
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Lab #5: Grignard Reaction – Synthesis of Triphenylmethanol John Kang Chem 152L Performed: 7/20/04 Date submitted: ________________ Lab Partners: Sang Lee‚ Vicky Lai TA: John Stanko Abstract: This experiment explored the synthesis of triphenylmethanol through the use of Grignard reagents. The percent yield of the product was 10% on a relatively humid day. The melting point was calculate to be 127.2oC with a literature value of 162oC. An IR spectrum of the product was taken and used
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