Genetic Information Tay Sachs is a devastating genetic disease. There are three different forms of the disease- Early Onset which emerges around three to six months of age‚ Juvenile which mainly appears between the ages of two and five but could start anytime in childhood‚ and Late Onset which mostly presents in adolescence or early adulthood but could occur at any time. Tay Sachs is caused by a mutation--a deletion of chromosome 15. The HEX A gene on this chromosome is responsible for creating
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Tay Sachs Disease Tay Sachs disease is caused by the homozygous recessive gene on chromosome 15 that codes for the lack of production of hexosaminidase-A (Hex-A) [1]. Since there is no HexA‚ a fatty substance is allowed build up abnormally in nerve cells‚ which damages the cells and the brain [1]. Males and females are equally likely to carry this recessive gene but the heterozygous gene carriers are not affected‚ because they still have the dominant gene [2]. If both parents have the heterozygous
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Tay-Sachs Disease History: The disease is named for Warren Tay (1843-1927)‚ a British ophthalmologist who in 1881 described a patient with a cherry-red spot on the retina of the eye. It is also named for Bernard Sachs (1858-1944)‚ a New York neurologist whose work several years later provided the first description of the cellular changes in Tay-Sachs disease. Sachs also recognized the familial nature of the disorder‚ and‚ by observing numerous cases‚ he noted that most babies with Tay-Sachs
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Emma Goldman perseverance towards equal rights‚ views on women‚ and reorganizing politics especially for women earned her‚ her place in history. Emma was born in Lithuania‚ but she moved to a czarist Russian ghetto called Kovno until 1886.(“Was My Life Worth Living?”‚ 2000) Her father discouraged her from having an education‚ and he told her that her only meaning in life was marrying and having a family.(“Emma Goldman: Overview‚ 2003) She moved to New York to live with her sister Lena at the age
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Tay-Sachs is a devastating disease affecting lysosomal storage. According to McCance & Huether (2014)‚ it is due to a deficiency in the lysosomal enzyme hexosaminidates A (HexA) that’s function is to degrade GM2 gangliosides (fatty acids) in nerve cells. Those diagnosed with Tay-Sachs do not have the ability to degrade this fatty acid and as a result‚ it builds up in the body causing nerve cell toxicity. It is genetically inherited through an autosomal recessive pattern meaning that both parents
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1. Stakeholder Theory vs. Shareholder Theory The Stakeholder Theory is defined as having three dimensions. The first dimension is that the stakeholders must contribute valued resources to the firm. The second dimension is how the stakeholders use these resources and the risks involved that could affect the success or failure of the firm and the relationship with that firm if it is terminated. The third dimension deals with the power that the stakeholders have within the firm. While one can be
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Stakeholders and Organizations Stakeholders are persons or groups that affect or are affected by an organization. They fulfill many roles within organizations. What is the most significant role stakeholders play in an organization? Why? How do stakeholders acting in this role influence the organization ’s mission‚ vision‚ and strategy? The answer to this question depends to a large degree who the stakeholder is and whether it is a market or nonmarket stakeholder (Lawrence & Weber‚ 2011). However
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definition of internal and external stakeholders This website shows the differnent stakeholders and how they influnece businesses. the main two businesses i am going to be investigating are McDonalds and cadbury. what are stakeholders? Stakeholders are people who own a share in the business‚ they have to buy the shares from the stock exchange or they have an influence or interest in the business. an example of a stakeholder of a school would be a govnor. they dont own a share but they influence
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Abc Stakeholders can be briefly defined as any party who are interested in an organization. This might be a member of an organization‚ volunteer‚ staff‚ management‚ board member‚ founder or a contracting body‚ client‚ community of interests such as locality or grouping of people who might benefit. Every business organization has a range of stakeholders. An organization is established based on blending the various interests of these stakeholder groupings. An objective to be the market leader of an
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