Experiment A1: Kinetics of the Reaction between Acetone and Iodine The key aim of this experiment was to determine the rate equation for the acid-catalysed iodination of acetone and to hence consider the insinuations of the mechanism of the rate equation obtained. The stoichiometric equation for the reaction between iodine and acetone is below‚ followed by the rate equation (where x‚y‚z and k are the values to be obtained): I2 + CH3COCH3 CH3COCH2I + HI -d[I2]/dt = k [I2]x [CH3COCH3]y [H+]z
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CONCEPTS IN ORGANIC CHEMISTRY • Inductive Effect : Inductive effect is defined as permanent displacement of shared electron pair in a carbon chain towards more electronegative atom or group. Types of Inductive effect : 1.Negative Inductive Effect : (—I effect‚ Electron withdrawing effect) when an electronegative atom or group (more electro negative than hydrogen)is attached to the terminal of the carbon chain in a compound‚ the electrons are displaced in the direction of the attached
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reactions of carbon-carbon bonds are important in organic synthesis [1-5]. In general‚ acylation reaction is one of the important carbon-carbon forming reactions. It belongs to the reactions of the enolate derived from a carbonyl group with an electrophilic carbon such as Aldol‚ Claisen‚ Michael reaction and alkylation of metal enolates [6-9].The acylation reaction as well as above other reactions of enolates has serious limitations to be overcome. In these reactions‚ a strong base NaOH is needed
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Synthesis of p-Nitroacetanilide (electrophilic aromatic substitution) In this experiment‚ we convert acetanilide to p-nitroacetanilide. [pic] The mechanism for the nitration is that of electrophilic aromatic substitution. The nitronium ion is directed to the positions ortho and para to the acetamido (-NHCOCH3) group. This occurs because the resonance electron-releasing effect of that group increases the electron density at those positions‚ helping to stabilize the intermediates that
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| Reactions of Grignard Reagents with Carbonyls | | | Tuesday 1:30 | 2/28/2012 | | Introduction This experiment explores the reactivity pattern for the addition of Grignard reagents to three different carbonyl groups: a ketone‚ an ester‚ and a carbonate. Grignard reagents are organometallic compounds that have a carbon-metal bond‚ such as carbon-magnesium. Grignard reagents are formed from the reaction of an alkyl‚ cycloalkyl‚ or aryl halide and magnesium metal in dry ether
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SUMMARY OF ORGANIC REACTIONS SECTION 1 - ALIPHATIC Aldehydes and ketones |Type of reaction |Mechanism | |1. oxidation (aldehydes only): aldehyde ( carboxylic acid |n/a | | | | |reagents: potassium
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analysis and boiling points were used to identify the product. The reactant and product are in equilibrium. The reaction was pushed forward by an excess of acid. The acetic acid contained an electrophilic carbonyl. The isopentyl alcohol acted as the nucleophile. The electrophilic compound attacked the nucleophile and produced both an ester and water. The sulfuric acid was used as a catalyst for this reaction. Experimental Acetic acid‚ concentrated sulfuric acid‚ and isopentyl
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threo-dibromide (opposite side of Fischer Projection) H Ph Br H CO2H Br H Br Ph Br H Christopher B. Martin CHEM 3411 4 2 3. Carbocation Intermediate Br H Br CO2H H Ph Br CO2H H Br (top face) Br H Ph Br CO2H H Ph H Electrophilic Addition of one Bromine Carbocation Intermediate Cis Addition of the Bromine Atoms Br CO2H H H Ph H Ph CO2H (bottom face) H Br Br Br CO2H CO2H Br H Ph CO2H H Br Ph Br H H H H Br Br Br Trans Addition of the Bromine Atoms H H
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an electrophilic aromatic substitution reaction‚ in which the nitro group replaces a proton of the aromatic ring. Following recrystallization‚ melting point and infrared were used to identify and characterize the product of the reaction. Purpose: The purpose of this experiment is to synthesize methyl nitrobenzoate from methyl benzoate‚ concentrated nitric acid‚ and concentrated sulfuric acid via an electrophilic aromatic substitution reaction. This experiment demonstrates an electrophilic aromatic
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The early twentieth century led to the discovery of penicillin‚ which revolutionized the use of curative agents to combat many bacterial contagions found around the globe. This was particularly useful in 1943 when the War Production Board outlined a plan to mass-produce a powdered formula of the drug to aid in the WWII American war effort.1 Penicillin’s use on Allied forces in the field reduced the number of amputations and deaths by an estimated 12-15%.2 Despite penicillin’s continued use today
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