acetic anhydride with sodium acetate. This step protects the amine functional group from doing unwanted reactions during chlorosulfonation and amination steps. The chlorosulfonyl group attacks in the para position to the acetamide group‚ by electrophilic aromatic substitution. Sulfonic acid is converted to 4-acetamidobenzenesulfonyl chloride by reacting with chlorosulfonic acid. The 4-acetamidobenzenesulfonyl chloride is converted to sulfonamide by reacting with aqueous ammonia. Acetamide group
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| Separation of Nitrophenols | | | | Abstract: Using a micro scale steam distillation we separated ortho and para-nitrophenol from a mixture that was already made. After the para and ortho were separated we measured their melting points and compared it to the literature values for purity. For ortho-nitrophenol we had 60% recovery and for para 160% recovery. Our melting point ranges were ortho: 45-46°C and para 64-95°C. Introduction: Nitration: In phenols‚ -OH group strongly
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Analysis of Hydrocarbons Jovellanos‚ Bien Jindrich Johannes; Lacson‚ Danise Angelica; *Lagula‚ Nina Francesca; Lañez‚ Kristine Department of Psychology College of Science University of Santo Tomas España Manila 1015 Abstract A hydrocarbon is strictly composed of carbon and hydrogen atoms only. Five hydrocarbons were used namely hexane‚ cyclohexene‚ toluene‚ naphthalene (in hexane)‚ and the unknown (which will be known through parallel chemical tests). Three tests‚ nitration test‚ bromine
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ETHERS Classification of Ethers: Symmetrical ethers – two groups attached to O are identical Ex. CH3CH2OCH2CH3 – diethyl ether Unsymmetrical ethers – two groups attached to O are not identical Ex. CH3CH2OCH3 – ethyl methyl ether Physical Properties of Ethers: Ethers have much lower boiling points compared to alcohols of comparable MWs. BPs of ethers increases with increasing MW. BPs of isomeric ethers increase with increasing alkyl chain length. BPs of ethers are about the
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enone “9” to form the aminopyrimidine “8” then “8” is reduced in the presence of palladium then refluxed for 21 hrs to form amine group which is replaced by nitro group‚ finally they added acid chloride 6 to 17 then the amine group attack the electrophilic carbon (the carbon near to Cl) and eliminate Cl
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UNIVERSITY OF SAN CARLOS DEPARTMENT OF CHEMISTRY NAME: Maniwang‚ Ma. Aiza C. DATE: March 21‚ 2011 COURSE: BS Chemistry II APPROVED: ___________ PREPARATION OF AZO DYES ABSTRACT In this experiment‚ the azo dyes p-nitrobenzene azoresorcinol and methyl orange were prepared by the azo coupling reaction. The p-nitrobenzene azoresorcinol dye was prepared from p-nitroaniline and resorcinol. The diazonium salt formed was from the reaction of the cold solution of dissolved p-nitroaniline
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Bromination of Acetanilide Objective: The objective of this experiment was to use melting point and NMR to determine which of two isomers‚ ortho or para‚ would most likely form after brominating Acetanilide through electrophilic aromatic substitution. Procedure/Observations: 1. Weigh out ~280 mg of acetanilide in a 10 mL r.b. flask with a stir bar. 2. Then‚ add 2.0 mL of glacial acetic acid using a calibrated Pasteur pipet. 3. Stir the mixture until all of the acetanilide has dissolved
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1. (a) Alkanes are saturated hydrocarbons.explain the words saturated and hydrocarbons. (b) Alkanes are generally unreactive. Explain why this is so. (c) write balanced equations for the complete combustion of: (i) methane (ii) ethane. 2. Use the passage below and your knowledge to answer the questions that follow. Methane reacts with bromine to give bromomethane and hydrogen bromide. The mechanism for the reaction is called free-radical substitution and involves
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can act as potential mediators capable of affecting signal pathways as those mediated by NF-κB (Evans et al.‚ 2002)‚ and proliferative and functional response of target cells (Parola and Robino‚ 2001). Lipid peroxidation also generates reactive electrophilic compounds‚ mainly α‚ β-unsaturated aldehydes. These compounds react with DNA
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determine the rate of the SN2 reaction: nucleophile‚ substrate‚ solvent and the leaving group. This reaction requires a lone pair from a nucleophile to donate an electron-pair in the formation of a chemical bond; it then attacks the bonds to an electrophilic
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