Lab 6: Electrophilic Aromatic Substitution(1) Nitration of Methyl Benzoate(2) Synthesis of 1‚4-Di-t-butyl-2‚5-dimethoxybenzene byFriedel-Crafts Alkylation of 1‚4-DimethoxybenzenePurpose1)To carry out the nitration of methyl benzoate‚ and then identify the major product formed (position at which nitro-group substitution takes place) by thin-layer chromatography (TLC)‚ the percent yield and the melting point range. 2)To synthesize 1‚4-Di-t-butyl-2‚5-dimethoxybenzene by Friedel-Crafts Alkylation of
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Bromination of acetanilide to 4-bromoaniline was studied in this experiment. One of the most important mechanism with the reaction of aromatic compounds is the electrophilic aromatic substitution reactions(wade‚2013). The electrophilic aromatic substitution enable scientists to make substituted aromatic compounds. However‚ substitution groups affect the electrophilic substitution mechanism. A nitrogen atom attached to hydrogen is learned to be a powerful activating group‚ which allow the procedure to go
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Methyl Benzoate Objectives: -To prepare methyl-3-nitrobenzoate from nitration of methyl benzoate by electropilic aromatic substitution. -To calculate the percentage yield and get the melting point of methyl-3-nitrobenzoate. Introduction: Benzene contains compounds have special properties that make them to react differently than other molecules. The conjugated compound of dienes in aromatic rings give an extra stability to undergo addition reactions
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benzoate‚ concentrated HNO3‚ and concentrated H2SO4 via an electrophilic aromatic substitution reaction. The HNO3 and H2SO4 were combined to form a nitrating solution‚ which was mixed with a mixture of methyl benzoate and H2SO4. Percent yield for the final product was calculated followed by recrystallization and melting point was measured. Introduction: Nitration of Methyl Benzoate is one of the examples of Electrophilic aromatic substitutions. The use of a mixture of Sulfuric Acid and Nitric Acid
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Preparation of 4-bromoaniline Introduction Aromatic compounds tend to undergo electrophilic aromatic substitutions rather than addition reactions. Substitution of a new group for a hydrogen atom takes place via a resonance-stabilized carbocation. As the benzene ring is quite electron-rich‚ it almost always behaves as a nucleophile in a reaction which means the substitution on benzene occurs by the addition of an electrophile. Substituted benzenes tend to react at predictable positions. Alkyl groups
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hexagonal ring of carbon called as benzene in their molecule. Aromatic hydrocarbon can contain one or more than one benzene ring. Those compounds which contain more than one benzene ring are known as polynuclear aromatic hydrocarbon like naphthalene‚ anthracene etc. The aromatic compounds are generally taken as derivatives of benzene. Benzene and its derivatives are mainly used in synthetic organic chemistry. The main source of polynuclear aromatic compounds is coal tar. For example‚ naphthalene is the
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Introduction: The purpose of this lab was to explore the concepts of electrophilic aromatic substitution‚ specifically nitration by synthesizing methyl m-nitrobenzoate using methyl benzoate‚ nitric acid and sulfuric acid. This nitration is a type of electrophilic aromatic substitution. A strongly charged electrophile‚ in this case a nitro group‚ replaces a proton on the aromatic ring. Aromatic compounds undergo substitution instead of addition to maintain resonance. The substituent on the benzene
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acetanilide after reacting with pyridinum tribromide in order to undergo electrophilic aromatic substitution. The melting point of the isolated products were measured against the standards in order to determine how strong of an ortho/para activator the compound was based on the product(s) and melting point obtained. Theory: Electrophilic aromatic substitution is an organic reaction that takes place when an atom that is bound to an aromatic ring is replaced by an electrophile. The electrophile replaces a
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Nitration of Methyl Benzoate to form Methyl-m-nitrobenzoate via Aromatic Substitution Linh Ngoc Thuy Nguyen Seattle Central Community College Professor: Dr. Esmaeel Naeemi Date: February 21st‚ 2012 Abstract In this experiment‚ methyl-m-nitrobenzoate‚ followed the electrophilic addition of aromatic ring‚ would be formed from the starting material methyl benzoate and nitric acid‚ under the catalysis of concentrated sulfuric acid. The reaction between nitric acid and sulfuric acid resulted
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nitronium ion. Electrophilic aromatic substitution is a method used when a functional group is needed to be substituted on to an aromatic compound. In the nitration‚ nitronium ion acts as the electrophile that involves the attack of the electron-rich benzene ring. Aromatic substitution is electrophilic‚ due to the high density in benzene ring. Benzene ring is one of the components in most important natural products and other useful products. The species reacting with the aromatic ring is usually
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