MSA University Faculty of Pharmacy Organic Chemistry Department Spectrometry Course Code: PC 222 Name: Ghazal Mhd Bassam Bakieh ID: 136909 Name: Christine Botros Mihail Bishay ID:124509 Name: Yaman Mhd Fawaz Hawasly ID: 137215 DR/ Hala I-Infrared spectrometer and sampling techniques Spectrophotometer Spectrophotometry in chemistry is a quantitative measure of the reflection or transmission of material properties as a function of wavelength. It is more
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Results and discussion The aqueous solubility of midazolam is a function of both the imidazobenzodiazepine ring opening‚ which is a fully reversible process‚ and the ionization of the drug molecule play an important role in the supramolecular complexation with water-soluble cyclodextrins (Loftsson et al.‚ 2001). Therefore‚ the total charges were assessed from the acid dissociation constant determined for different forms of midazolam as depicted in Figure 1. First‚ predicted negative decimal logarithm
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CHAPTER 3 Studies on Mn (II)‚ Co (II)‚ Ni(II)‚Cu(II)‚Zn(II) and Cd(II) Complexes of Dimedone bis Semicarbazone (H2DSC) During the past few decades‚ major developments have been achieved in the research of coordination compounds with special emphasis on metal complexes of Schiff bases containing nitrogen and oxygen donors 1-5 . This may be due to their stability‚ biological activity5-6and potential applications in many fields 9-10. Biological activity of complexes derived from semicarbazide has
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Causes and spread of Infection 1. Understand the causes of Infection 1.1 Identify the differences between bacteria‚ viruses‚ fungi and parasites More accurately‚ parasites are actual animals‚ along with mites‚ and mites are so small you have some thousands living in your eyebrows. Bacteria are one cell things with a cell wall. Virae (viruses) are code only--they are the core requirement that bacteria have‚ but without all the other protective layers like cell wall and energy production. Instead
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ulcerative colitis. Budesonide is provided as a mixture of two epimers (22R and 22S). Interestingly‚ the 22R form is two times more active than the 22S epimer. The two forms do not interconvert. Solubulity :. Soluble in DMSO (100 mM)‚ ethanol (50 mM)‚ chloroform‚ Half life :Following IV administration of budesonide‚ the elimination half-life is 2.0 to 3.6 hours. This value does not differ between healthy adults and patients with Crohn’s disease. Mechanism of action : Budesonide
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The vas deferens is the small tubes that transport the sperm cells from the testes. As stated by ScienceDaily‚ “it is composed of high molecular weight polymer powder dissolved in dimethyl Sulfoxide (DMSO)‚ a biocompatible solvent.” (ScienceDaily) The resulting vasalgel implant remains in a soft gel-like state that allows water-soluble molecules to pass but not larger structures‚ such as spermatozoa. This quality is thought to be beneficial for preventing
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leaving groups are: H2O‚ CH3OH‚ OTs‚ ISolvent: Polar protic solvents are the worst for SN2; they solvate the nucleophile so it cannot attack Polar aprotic solvents stabilize the transition state and speed SN2 reactions up Polar aprotic solvents are DMSO‚ DMF‚ CH3CN‚ HMPA Notes: The SN2 reaction is bimolecular - it depends on amounts of nucleophile and leaving group In synthesis‚ always convert an OH leaving group into an OTs leaving group Converting an OH into an OTs will NOT change the stereochemistry
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680cc-flame. The magnetic susceptibility values were obtained at room temperature using Magnetic Susceptibility Balance Bruke Magnet B.M.6. The 1H and 13C nuclear magnetic resonance spectra were recorded on a jeol 400 MHz spectrometer in dueteated DMSO‚ relative to the internal standard Tetramethylsilane (TMS). Conductivity measurements were carried out by using a WTW conductivity meter . Synthesis of Ag (I) complexes A solution of (2.5 mmole) of AgNO3 dissolved in 50 ml of water was added
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Drug-Eluting Stents to Prevent Coronary Restenosis Szycher M‚ Ph.D.*; Armini A‚ Ph.D.; Bajgar C‚ Sc.D.; Lucas A * CardioTech International‚ Inc.‚ 78E Olympia Avenue‚ Woburn‚ MA 01801‚ and Implant Sciences Corporation‚ 107 Audubon Road‚ Suite 5‚ Wakefield‚ MA 01880. Copyright 2002. All rights reserved. IMX Paper v2 ______________________________________________________________________________________ Background – The development of coronary stents has revolutionized the practice of interventional
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2-a]pyrimidin- 4-one. Its molecular formula is C23H27FN4O2 and its molecular weight is 410.49 (Salwan et al. 2013) Risperidone is a white to slightly beige powder. It is practically insoluble in water‚ freely soluble in methylene chloride‚ soluble in DMSO (Dimethyl Sulfoxide) and soluble in methanol and 0.1 N HCl. Risperdal tablets are available in 0.25 mg (dark yellow)‚ 0.5 mg (red-brown)‚ 1 mg (white)‚ 2 mg (orange)‚ 3 mg (yellow)‚ and 4 mg (green) strengths. Tablets of 0.25‚ 0.5‚ 2‚ 3‚ and 4 mg also
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