Introduction Hemophilia is a rare genetic blood clotting disorder that primarily affects males. People living with hemophilia do not have enough of‚ or are missing‚ one of the blood clotting proteins naturally found in blood. Two of the most common forms of hemophilia are A and B. In persons with hemophilia A (also called classic hemophilia)‚ clotting factor VIII is not present in sufficient amounts or is absent. In persons with hemophilia B (also called Christmas disease)‚ clotting factor
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Hemophilia is the most common inherited coagulation disorder. Although hemophilia is commonly inherited‚ it can also occur due to a spontaneous mutation. Hemophilia A is an X-linked‚ recessive disorder caused by a deficiency of Factor VIII. Hemophilia can be severe‚ moderate‚ or mild. Individuals diagnosed with severe hemophilia A are typically diagnosed early in life‚ prior to age two. This is diagnosed particularly following episodes of bleeding from mouth injuries and bumps on the head.
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correct order of draw when evacuated tube method is used. Gold top tubes contain Serum Separator Gel which are used for chemistry‚ immunology and serology tests and requires 5-6 inversions. Light blue tubes contain sodium citrate which are used for coagulation tests and only requires 3-4 inversions. Black top tubes on the other hand contain buffered sodium citrate which are used for erythrocyte sedimentation rate and requires 8-10 times inversions. Red plastic tubes which contain silica enhances clot
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Hemophilia is a genetic bleeding disorder. People who have hemophilia have a deficiency or an absence of a coagulation protein. A blood clotting factor is deficient or absent. Bleeding is most often into joints‚ such as the knee‚ elbow‚ or ankle‚ but bleeding can occur anywhere in the body. People with hemophilia bleed longer‚ not faster. The severity of hemophilia varies greatly. Hemophilia A and Hemophilia B are the most common genetic bleeding disorders. Hemophilia A is observed in 80 percent
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Hemostasis "How does our body handle bleeding?" Model 1: blood clotting platelet serotonin (vasoconstrictor) prothrombin activator (active) Ca2+ Prothrombin (inactive) thrombin ! fibrinogen (soluble) fibrin! (insoluble) Part 1: Platelet Plug Formation Part 2: clot formation (occurs after plug formation) Critical thinking questions: 1. Although not pictured in the model above‚ the first thing that happens when a blood vessel is torn is vasospasm‚ in which the
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healing. Hemostasis can be divided into two stages: Primary and Secondary. 1- Primary hemostasis includes the platelet and vascular response to vessel injury. 2- Secondary hemostasis includes the coagulation factors response to such injury. Together‚ platelets‚ vessels‚ and coagulation factors combine to stop bleeding and allow for vessel repair through formation of a stable fibrin-platelet plug at the site of injury. Primary Means‚ it is individual there is no dependence‚ But Secondary
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sepsis are abnormalities of body temperature‚ pulse‚ respirations‚ and white blood cell counts. When sepsis is associated with one or more organ dysfunctions‚ it is referred as severe sepsis. Organ dysfunction can be defined as acute lung injury; coagulation abnormalities; thrombocytopenia; altered mental status; renal‚ liver‚ or cardiac failure; or hypo-perfusion with lactic acidosis. Septic shock is defined as sepsis-induced hypotension with lower than 90 mm Hg or reduction by 40 mm Hg or more from
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peripheral blood film is an important indicator of hematological and other disease. ← Blood smear ← 3. Coagulation test A. Bleeding Time Test ← Bleeding time is a very popular blood test that is primarily used to gauge the speed with which the blood is able to clot. ← The clotting of blood incorporates the functionality of a number of factors such as coagulation factors‚ platelets‚ as well as small vessel vasospasm. ← Methods of
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followed by renal failure. It was argued that when Thomas beat the victim‚ the tissue damage was so extensive that extracellular fluid accumulated within the tissue layers following ischaemia repercussion. This led to disseminated intravascular coagulation which cause an overall intravascular volume depletion that made it impossible for the victim to participate in basic activities such as sitting up and
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prevent deep vein thrombosis (DVT) and pulmonary emboli (PE)‚ myocardial infarction‚ open heart surgery‚ disseminated intravascular clotting syndrome‚ and atrial fibrillation with embolization. It is also used as an anticoagulant in transfusion and dialysis procedures‚ to maintain patency of indwelling venipuncture devices‚ and diagnosis and treatment of disseminated intravascular coagulation (DIC) (p.517). In Pharmacology and the Nursing Process (2013)‚ Pharmaceutics
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