Preparation and melting point of Aspirin Aspirin is a painkilling drug and is produced worldwide to reduce and stop pain. Aspirin is made up of ehtanoylation of 2-hydroxbenzenecarboxylic acid in a presence of phosphoric acid. AIM: The aim of the experiment is to prepare and produce aspirin as pure as possible. I will do this threw preparing the aspirin and purifying the product threw recrystallization. I will then obtain a melting point of my product to get an estimate of its purity. By the end
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Synthesis of Aspirin and Oil of Wintergreen INTRODUCTION: Synthesis and use of organic compounds is an extremely important area of modern chemistry. Approximately half of all chemists work with organic chemicals. In everyday life‚ many if not most of the chemicals you come in contact with are organic chemicals. Examples include drugs‚ synthetic fabrics‚ paints‚ plastics‚ etc. Synthesis of Aspirin and Methyl Salicylate. The two compounds we will be preparing‚ aspirin (acetylsalicylic acid) and oil
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b. Characterization of Aspirin B. Set – up Fig. 11.1. Suction Filtration Set – up C. Table 11.1 List of Necessary Chemicals Sample Structure Purpose Physical Properties Hazards Salicylic Acid Starting Material Appearance: white powder Molar Mass: 138.12 g/mol Melting Point: 1590C Boiling Point: 2110C Density: 1.44 g/cm3 Mildly irritating (pulmonary irritants). Harmful by inhalation‚ ingestion and through skin absorption. Acetic Anhydride
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Greaves Chem3301-112 June 19‚ 2013 Synthesis of Aspirin from Methyl Salicylate Introduction The synthesis of Aspirin (Acetyl Salicyclic Acid) began with methyl salicylate and sodium hydroxide as the reagent. The polar oxygen accepts the electrons from now positively charged hydrogen. The positively charged sodium disassociates leaving the hydroxide ion with a negative Scheme 1 shows the mechanisms that were demonstrated during the synthesis of Aspirin. charge that attracts to the positively charged
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Formal Report no. 1 Synthesis of Aspirin Chemical Principles Aspirin is most widely sold over-the-counter drug. It has the ability to reduce fever (an antipyretic)‚ to reduce pain (an analgesic)‚ and to reduce swelling‚ soreness‚ and redness (an anti-inflammatory agent). Much of this is believed to be due to decreased production of prostaglandins and thromboxanes. Aspirin’s ability to suppress the production of prostaglandins and thromboxanes is due to its irreversible inactivation of the cyclooxygenase (COX)
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Once the aspirin is prepared‚ it is isolated from the reaction solution and then it is purified. The aspirin is insoluble in cold water‚ and it is isolated by filtering the chilled reaction solution. Purification is essential to remove any unreacted salicylic acid and acetic anhydride as well as the acetic acid product and phosphoric acid. Acetic anhydride is caused to decompose by the addition of water once the formation of aspirin is complete. C4H6O3 (Acetic anhydride) + H2O (Water) ------------------------->
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Formal Lab Report 1 Chemistry 100-03 March 19‚ 2012 Abstract: • Introduction/Objective: Prepare and analyze aspirin from salicylic acid and acetic anhydride‚ and calculate the percent yield of the synthesized aspirin. • Materials and Methods: This experiment called for the synthesis of acetylsalicylic acid‚ or aspirin‚ by using salicylic acid‚ acetic anhydride‚ sulfuric acid‚ and vacuum filtration. The salicylic acid and the acetic anhydride were mixed in a flask. Sulfuric
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Experiment 2 and 3: Synthesis of Aspirin and Determination of Melting Point A. Abstract Aspirin is the common name for the compound acetylsalicylic acid‚ widely used as a fever reducer and as a pain killer. The first part of the experiment aims to synthesize aspirin from the reaction of salicylic acid with acetic anhydride with the aid of phosphoric acid as a catalyst. The second part of the experiment aims to assess the purity of aspirin through the determination of its melting point and
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OF ASPIRIN Abstract This report gives a detailed account of the experimental preparation of aspirin in a laboratory environment as well as some basic industrial background on the product. It also contains information about safety precautions put in place to ensure the safety of the team who carried out the experiment. All results obtained have been included as well as a detailed analysis of what they represent alongside any improvements to the method used. Introduction The aim of this experiment
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Conclusion: The purpose of this lab was to synthesize and purify aspirin. The theoretical yield was calculated to 3.766g. The actual yield of pure aspirin was 2.863g with a yield of 76%. The percent yield indicates that our synthesis was a success but the yield is low and indicates that some of the aspirin was lost during synthesis. Some reasons for loss can result from human error such as loosing product from sticking on the spatula and the Buchner funnel and several weighings. Also‚ when transferring
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