Analgesics Using the thin layer chromatography the major components of a commercial analgesic tablet will be indentified and purified. The active ingredients of the analgesic used were characterized by comparison with chromatograms of aspirin‚ acetaminophen‚ ibuprofen‚ mefanemic acid‚ and caffeine through the use of UV chromatography then the Rf value was calculated for each solvent. INTRODUCTION In this experiment‚ thin-layer chromatography (TLC) will be used to determine the composition
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over-the-counter classifications of painkillers are acetaminophen‚ nonsteroidal anti-inflammatory drugs (NSAIDs)‚ and salicylates. One of the most popular over-the-counter drugs used to relieve pain is Tylenol. Tylenol is the brand name for acetaminophen or paracetamol. Consumers take acetaminophen to relieve mild to moderate pain such as for osteoarthritis or headaches. The National Center for Biotechnology Information (NCBI) says that acetaminophen works by changing the way the body senses pain (2012)
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prepared by reacting salicylic acid with acetic anhydride:  Figure 1. Chemical Equation for Aspirin Synthesis (Aspirin) Tylenol‚ acetaminophen‚ is also used both as a fever reducer and pain reliever. Acetaminophen is prepared by reacting ammonia with acetic acid:  Figure 2. Chemical Equation for Tylenol Synthesis (Acetaminophen) The purity of an aspirin or Tylenol sample can be obtained by determining the melting point. The presence of impurities always lowers the melting
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in 24 hours” and “adults and children 12 years of age and over: 2 caplets every 6 hours while symptoms persist”. (Benadryl) So what happened in this case? Acetaminophen is an active ingredient in Benadryl® Maximum Strength Severe Allergy and Sinus along with Diphenhydramine and Pseudoephedrine. In each capsule‚ there is 500 mg of acetaminophen‚ therefore the is 1000 mg in one dose‚ and 4000 mg
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------------------------------------------------- Drug Name: Hydrocodone/Acetaminophen Trade Name: Vicodin ------------------------------------------------- Indication: Relief of moderate to severe pain ------------------------------------------------- Safe Range: Peds: <40kg 0.2mg/kg-15mg/kg/dose q3-4h PRN. Maximum dose of acetaminophen 1000 mg/dose and 4000mg/day; Adult initially 10mg q3-4h PRN. ------------------------------------------------- Action / Where does it
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where the given distance from origin to solvent front measures 59 mm: 1.) acetaminophen has a Rf value of 0.48; 2.) aspirin has a Rf value of 0.64; 3.) caffeine has a Rf value of 0.22; 4.) Biogesic® sample has a Rf value of 0.48 ; 5.) ibuprofen has a Rf value of 0.73; and 6.) mefenamic Acid has a Rf value of 0.76. Thus‚ the study shows that by having equal Rf values of about 0.48‚ Biogesic®’s most active component is acetaminophen (paracetamol)‚ a relatively polar compound having a molecular formula
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through melting point‚ percent recover‚ and Rf values. The comparable data for acetaminophen from the manufacturer is 500mg of active ingredient. After conducting the experiment-extraction‚ distillation‚ and evaporation- 451mg of active ingredient. This relates to a 68.1% recovery. The melting point was between 158 and 165 degrees Celsius‚ which is almost ten degrees lower than the published melting point of acetaminophen. After conducting a TLC plate‚ the Rf value was calculated to be .4268‚ the same
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Organic Chemistry Lab Introduction: Panacetin purportedly includes sucrose‚ aspirin‚ and acetaminophen. However‚ the accuracy of Panacetin’s contents has been called into question by the Association for Safe Pharmaceuticals. Therefore‚ the lab must discover the accuracy of the ingredients listed on Panacetin’s label. The unknown in this experiment is presumed to be something similar to acetaminophen‚ such as acetanilide or phenacetin. Recrystallization and melting point temperature were
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Objective: The goal of the experiment was to use UV/VIS spectroscopy to collect data to quantify acetaminophen‚ aspirin‚ and caffeine from a migraine tablet where there is heavy spectral interference using Target Factor Analysis1. The migraine tablet has other ingredients in it like FD&C blue #1‚ stearic acid‚ and saccharin. Saccharin is the ingredient thought to have the biggest interference and was used as the experimental basis2. Instruments: UV/VIS spectroscopy was used to analyze the absorption
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Wednesday‚ May 8th‚ 2013 | | | 5/15/2013 | | Introduction: The goal of this experiment was to identify an unknown analgesic drug through the use of thin-layer chromatography. The drugs used were‚ Unknown #1‚ caffeine‚ aspirin‚ and acetaminophen. Thin-Layer Chromatography is a technique for identifying substances using a mobile phase (developing solvent) that draws up through a stationary phase (TLC plate) and marks spots of differing distances for differing substances. (1) The TLC
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