Preparation of SKEO The extraction of S. khuzistanica was performed by hydro distillation and clevenger apparatus for 5 hours. Once extraction was completed‚ the resulted essential oil was dehydrated using sodium sulfate (Merck). The essential oil was stored at temperature of 4ºC until using (12). In order to provide different concentrations of the extract‚ Dimethyl sulfoxide (DMSO) was used. Gas chromatography/mass spectrometry analysis of essential oil Isolation and measurement of the sample
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3. Summarize an article from a peer reviewed journal dealing with one of the topics presented in the article. The article reviewed discussed the topic of human cytotoxicity in response to exposure to glyphosate‚ its major metabolite (AMPA)‚ and the commonly added surfactant compounds found in major herbicides. Glyphosate exposure has increased world-wide at an exponential rate along with the production of genetically modified crops. Currently up to 75% of genetically modified crops are treated
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Results and Discussion: A reaction involving two bond formation was employed for the preparation of 3‚5-disubstituted 1‚2‚4-triazole as nucleobase analog. The hydrazides 2a‚b were allowed to react with the heteroaryl substituted acetonitrile derivatives 1a-c using catalytic amount of K2CO3 and n-butanol as a solvent to afford the disubstituted 1‚2‚4-triazoles 3-7 bearing benzothiazole‚ benzotriazole‚ quinoloxymethyl and benziimidazole ring systems in moderate yields. The structures of compounds
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ABSTRACT Purpose: To evaluate the antifungal and cytotoxicity activity of four medicinal plants like Mystroxylon aethiopicum‚ Lonchocarpus capassa‚ Albizia anthelmentica and Myrica salicifolia. Methods: Microdilution method and brine shrimp lethality test were employed to evaluate antifungal and cytotoxicity of plant extracts. Results: Lonchocarpus capassa leaf extracts exhibited antifungal activity against tested fungal strains with MIC range of 0.78 – 3.125 mg/mL with LCLA extract inhibiting C
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CHEMICAL MEDIATORS OF INFLAMMATION Cell derived mediators Mediator | Source | Function | Vasoactive amines | Histamine | Mast cells‚ basophil‚ platelet | Vasodilation‚ ↑ vascular permeability‚ endothelial activation | Serotonin | platelets | Vasodilation‚ ↑ vascular permeability | Eicosanoids | Prostaglandins | Mast cells‚ leukocytes | Vasodilation (PGD2‚PGE1‚E2 & PGF2-α)‚ pain (PGE2)‚ fever | Thromboxane A2 | | Promotes platelet aggregation‚ vasoconstriction | Prostacyclin
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It was observed that the test compound showed minor cytotoxicity as compared to the positive control‚ and the IC50was found to be 110µgm192-93. In last phase‚ it was planned to assess the anticancer activity of the selected quinazoline derivatives against MCF7 (Human breast cancer cell lines) and HCT116 (Human
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numerous methods used and the end points measured in cytotoxicity can be grouped into the following
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magnetic resonance (NMR) techniques. PLGA-heparin (PLGAh) and PLGA-heparin-quercetin (PLGAh+Q) loaded microspheres were characterized for morphology using scanning electron microscopy (FESEM). The PLGAh and PLGAh-Q microspheres were tested for its cytotoxicity against MCF-7 lines.
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Philippine Normal University- Mindanao Campus‚ Prosperidad‚ Agusan del Sur‚ Philippines Abstract The present study was conducted to determine the lethal concentrations of the different parts of Dioscorea hispida through Brine Shrimp Lethality Assay. Cytotoxicity was evaluated in terms of lethal concentration. Each part of the plant was powdered and 0.1 gram of it was added to the first of the five wells. One (1) mL of the mixture was added to the vials with different concentrations. Fifteen brine shrimp
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into the cell releasing its payload‚ and effectively mediate the gene silencing pathway158. The cationic nature of chitosan and its derivatives has inspired the investigators to use them as promising non-viral gene vectors because of their less cytotoxicity‚ and immunogenicity‚ non-mutagenesis response in comparison with the viral vectors‚ polyarginine and polyethylene imine (PEI). As well as‚ their ability in the formation of stable
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