Cisplatin Resources 1. M. H. Hanigan and P. Devarajan‚ “Cisplatin nephrotoxicity: molecular mechanisms‚” Cancer Therapy‚ vol. 1‚ pp. 47–61‚ 2003. 2. Santiago Gómez-Ruiz‚ Danijela Maksimović-Ivanić‚ Sanja Mijatović‚ and Goran N. Kaluđerović‚ “On the Discovery‚ Biological Effects‚ and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy‚”Bioinorganic Chemistry and Applications‚ vol. 2012‚ Article ID 140284‚ 14 pages‚ 2012. 3. N/A 4. Santiago Gómez-Ruiz‚ Danijela Maksimović-Ivanić‚ Sanja
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Contents 1.0 Abstract Acetaminophen and aspirin are both well-known drugs that relieve pain and reduce fever. This report looks at acetaminophen as a potential substitute for a patient who is allergic to aspirin. Acetaminophen‚ a common analgesic drug that can be bought over the counter‚ was synthesised by Hormon Northrop Morse. With acetaminophen consisting of a benzene ring‚ an amide and an alcohol group‚ it has the ability to stop pain and reduce fevers. However‚ due to the state of technology
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Undergraduate Questions (50 Pts) 1. (4 pts) A chemist working in a pharmaceutical lab synthesized a new drug as a racemic mixture. Why is it important that she separates the two enantiomers and test each for its biological activity? 2. (6 pts) Phosphoric acid (H3PO4) has three dissociable protons‚ with the pKa’s shown below. Which form of phosphoric acid predominates in a solution at pH 4? Explain your answer. Acid pKa H3PO4 2.14
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Acetylsalicylic Acid (Aspirin) Synthesis Telow‚ AJV Sumicad‚ CJ‚ Tavanlar‚ EMMT‚ Chem 40.1‚ Institute of Chemistry‚ University of the Philippines Los Baños I. Introduction Organic synthesis is the process where a desired organic compound is constructed or prepared from commercially available materials. The objective of organic synthesis is to design the simplest synthetic routes to a molecule. Aspirin‚ also known as acetylsalicylic acid is as salicylate drug often used as analgesic
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the percentage composition of the label (50% paracetamol‚ 40% aspirin and 10% sucrose) matches that of the percentage composition of the powder by following 10% ranges of each component in the powder. I am going to do this via a number of methods including vacuum filtration‚ heating‚ extraction and evaporation. Experimental method: The experiment was done in three parts: firstly the separation of sucrose‚ then the separation of Aspirin and the isolation of the unknown component. 1. Separation
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describe the functioning of Aspirin in our body‚ its various properties to fight pain‚ and its evolution over the years. Littlejohn describes how Aspirin claimed celebrity status as one of the world’s most popular‚ inexpensive painkillers by relieving headaches‚ sprains‚ blows‚ burns‚ swelling and fever. Furthermore‚ she added that Aspirin could also be used to reduce the risk of stroke and heart attack. The author supports the main idea by describing how the aspirin when taken with a modest stream
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future. The purpose of this experiment‚ is essentially to determine the purity of the product that is collected and filtered and recrystallized. Experimental Procedure: The experimental procedure used for this experiment was outlined in the CHEM 123L lab manual‚ Experiment #1. All steps were followed without deviation. Experimental Observations: Table 1: Experimental Data Values obtained in the Experiment Observation Value of
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! Isolation of the Components of BC Powder Introduction Aspirin‚ Caffeine and Salicylamide were extracted from an over-the-counter pain reliever (BC Powder). These components were separated by manipulating their solubilities by adjusting the acidity and basicity of the solution. By doing this‚ the three components were forced into conjugate acid (or base) forms‚ causing selective solubility in either an aqueous or organic solvent. These layers were then separated by use of a separation funnel
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Health and Human Services. (n.d.). Retrieved from http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/017463s104lbl.pdff‚ 2006 afely/UnderstandingOverthecounterMedicines/SafeDailyUseofAspirin/ucm291433.html‚ 2012. USDH published facts about Aspirin‚ including common and major side effects‚ the benefits of taking the drug‚ including heart health‚ and dosage information. Medline plus. (n.d.). Retrieved from http://www.nlm.nih.gov/medlineplus/druginfo/meds/a681004.html‚ 2012
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INTRODUCTION 3 2.1 The background information of Aspirin 3 2.11 History 3 2.12 chemical structures 4 2.2 The background information of Acetaminophen 5 2.21 History 5 2.22 Chemical Structures 6 3.0 BODY 6 3.1 Synthesis 6 3.11 Synthesis of Aspirin 6 3.12 Synthesis of Acetaminophen 7 3.2 Mechanism of Action in Human Body 9 3.2.1 Pain as a warning system 9 3.2.2 Aspirin 9 3.2.3 Acetaminophen 10 3.3 Side effects 10 3.3.1 Side effects of Aspirin 10 3.3.2 Side effects of Acetaminophen 11 4
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