Objective The present study was conducted to evaluate the neuroprotective effect of curcumin nanoparticles (CUR NP) against the neurotoxicity induced by cisplatin (CP) in rat. Material and methods: Rats were divided into control group that received saline solution; CP-treated rats that received a single i.p. injection of CP (12 mg/kg) and CP-treated rats that received a single i.p injection of CP (12 mg /kg) followed by a daily oral administration of CUR NP (50 mg/kg) for 14 days. At the end of the
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CHAPTER CHEICAL BASIS OF LIFE OUTLINE The human body is composed of chemicals. Chemistry describes the composition of substances & how chemicals react with each other. STRUCTURE OF MATTER ELEMENTS are composed of atoms‚ which are the smallest unit of element MATTER is composed of elements ATOMIC STRUCTURE • A complete atom is electrically neutral • Atom consists of elements‚ protons‚ & neutrons • Electrons are negative charge & • Neutrons are uncharged( neutral) • Atomic number is equal
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Needs to be well thought out Realistic and impactful How to pick a topic? Lecture slides Review articles- Nature reviews are the best As recent as possible Topics- CR‚ oxidative stress‚ mutation accumulation‚ autophagy‚ FOXO‚ sirtuins‚ mTOR‚ apoptosis‚ mitochondrial hormesis‚ antiaging pills How to design experiments? What model? What hypothesis? Its probably been done before so look for this How do I write proposal Background‚ objectives- how you will examine hypothesis‚ proposed research-
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created by pumping hydrogen ions into their interiors. ____ 4. The chief function of ribosomes is to provide sites for lipid synthesis. ____ 5. If cells are deprived of communication from extracellular chemical messengers‚ most cells experience apoptosis. ____ 6. Non-dividing cells‚ such as myocardial fibers‚ are capable of hypertrophy‚ but not hyperplasia. ____ 7. Dysplasia is a common type of normal cellular adaptation. ____ 8. Hypertrophy and hyperplasia rarely occur together. ____
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. Introduction A. Background of the Study One of the more common occurrences in our daily life is sustaining wounds ranging from mild abrasions to deep lacerations. Wounds that are left untreated can result to infections and other complications‚ so proper remediation must be done immediately. For the past several years‚ there has been a lot of advancement in the field of medicine. The discovery of new drugs has played a big role in the improvement of our health care. But due to the prohibitive
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Infertility/ Subfertility • one year of unprotected intercourse with the same partner without conception. • 10-15 % of couples • Multifactorial infertility male tubal & peritoneal ovulatory cervical & other Homocysteine & Fertility Dr. S. Bhanu Rekha Assoc. Prof SVS Pioneers Dr .Vigneaud 1933 Dr .Kilmer Mc Cully 1968 What is Homocysteine ? Protein diet Digestion Metabolism Methionine Auto-oxidation Protein synthesis 2)Homocystine 1)Homocysteine HS-CH2-CH2-CH-COOH NH2 Homocysteine •
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Coronary artery disease (CAD) is a progressive disease that causes narrowing or occlusion of the coronary arteries‚ causing a decreased blood supply to the myocardial layer of the heart‚ and prevents the arteries from dilating. As a result the tissue is deprived of oxygen necessary to thrive‚ which in turn can lead to myocardial ischemia‚ leading to several types of infarctions. Depending on the area of the ischemia‚ there can be several complications. For example‚ a ST segment elevation myocardial
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Glioblastoma (GBM) and the relationship with cancer stem cells Cancer stem cells may originate from normal stem cells‚ progenitor cells or from differentiated cells that revert to a stem-like phenotype. Under certain pressures such as therapy induce pressure the cell stems will potentiate the production of new cells that can be inherently resistance to the treatment that would be used4 . Cancer stem cell is known to have the ability to self-renew and maintain the tumor. Laboratory research have shown
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Cow’s milk allergy (CMA) is one of the major causes of food hypersensitivity in children. The clinical features of CMA express as immediate symptoms‚ ranging from mild local reactions to life-threatening anaphylaxis.‚ which may involve the skin (eg‚ urticaria and eczema)‚ respiratory tract (eg‚ asthma and rhinoconjuctivitis)‚ gastrointestinal tract (eg‚ vomiting‚ diarrhea‚ and colic)‚ or systemic anaphylactic shock. Cow’s milk contains more than 25 different proteins that are among the best characterized
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matrix pH when generation polyphosphates groups or decreasing magnesium of matrix [113]. During ischemia reperfusion‚ surprisingly at the‚ MPTP is opened and Pi is elevated. There is calcium overloading thanks to ROS generation‚ thus necrosis and apoptosis happen
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