Preparation of 4-bromoaniline Introduction Aromatic compounds tend to undergo electrophilic aromatic substitutions rather than addition reactions. Substitution of a new group for a hydrogen atom takes place via a resonance-stabilized carbocation. As the benzene ring is quite electron-rich‚ it almost always behaves as a nucleophile in a reaction which means the substitution on benzene occurs by the addition of an electrophile. Substituted benzenes tend to react at predictable positions. Alkyl groups
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the procedure outlined in Appendix A of the Lab Manual‚ approximately equal samples of p-Nitrophenol and acetanilide‚ which are known to have the same melting range of 113-114 degrees Celcius‚ were taken and inserted into the melting point apparatus. The melting points of the compounds were noted and found to be very similar. Next‚ approximately equal amounts of p-Nitrophenol and acetanilide were mixed on a clean watch glass. A sample of the mixture was placed in the Mel-temp apparatus as before
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Compounds by Solvent Extraction Introduction The purpose of this experiment was to use solvent extraction techniques in order to separate a mixture consisting of a carboxylic acid (p-toulic acid)‚ a phenol (p-tert-butylphenol)‚ and a neutral compound (acetanilide). Extraction is the process of selectively dissolving one or more of the compounds of a mixture into an appropriate solvent‚ the solution that contains these dissolved compounds is called an extract (Manion‚ 2004). Impurities that are present
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Mapua Institute of Technology Organic Chemistry Laboratory 2 Final Report Factors Affecting the Relative Rates of Electrophilic Aromatic Substitution Reaction Justiniano‚ Priscilla Raiza N. School of Chemical Engineering and Chemistry‚ Mapua Institute of Technology‚ Intramuros‚ Manila‚ Philippines Experiment No.1‚ Submitted on August 6‚ 2011 at N402. Abstract EXPERIMENT NUMBER ONE IS ALL ABOUT THE ELECTROPHILIC SUBSTITUTION OF AROMATIC COMPOUNDS. AROMATIC COMPOUNDS ARE THOSE ORGANIC
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Experiment 3 Objectives Separation by Solvent Extraction To separate a mixture consisting of a carboxylic acid and a neutral compound by using solvent extraction techniques. Introduction Frequently‚ organic chemists must separate an organic compound from a mixture of compounds‚ often derived from natural sources or products of synthetic reactions. One technique used to separate the mixture compounds is called extraction. Extraction is a process
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(2‚4‚6 tribromoaniline‚ mp of 108-110 C) respectively. Discussion and Conclusions: Interpreting these results have concluded that relative reactivity of these three anilines in order of most reactive to least reactive go; Aniline > Anisole > Acetanilide. Aniline‚ has an NH2 ‚ the most active substituent ‚ and adds to any ortho/para position available on the ring. This data is confirmed with the product obtained‚ (2‚4‚6 tribromoaniline‚ mp of 108-110 C). As for anisole‚ it has a strongly activating
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: Paracetamol (325mg)‚ a non-opioid and non-salicylate analgesic. It is indicated for the treatment of moderate to severe pain. Name Acetaminophen Drug Type Small Molecule Approved Description Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic‚ but may cause liver‚ blood cell‚ and kidney damage. Synonyms Acetaminofen Paracetamolo Paracetamol Brand Taken Crocin - Remidex Pharma Calpol -
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composed of sucrose (10%)‚ aspirin (40%)‚ and Tylenol (50%). Although this information is reported‚ the true composition of Panacetin is questionable. While sucrose and aspirin are present in Panacetin‚ Tylenol may be replaced by an unknown component (acetanilide or phenacetin). Separation of the components of a sample of Panacetin may prove valuable in identification of the unknown component‚ as well as the true percent composition of each component of Panacetin. This experiment involves two parts‚ covering
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Objective: Separate and purify acetanilide from a mixture by recrystallization. Compare the melting points of crude and recrystallized acetanilide. Introduction : The most common method of purifying solid organic compounds is by recrystallization. In this technique‚ an impure solid compound is dissolved in a solvent and then allowed to slowly crystallize out as the solution cools. As the compound crystallizes from the solution‚ the molecules of the other compounds dissolved
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The early twentieth century led to the discovery of penicillin‚ which revolutionized the use of curative agents to combat many bacterial contagions found around the globe. This was particularly useful in 1943 when the War Production Board outlined a plan to mass-produce a powdered formula of the drug to aid in the WWII American war effort.1 Penicillin’s use on Allied forces in the field reduced the number of amputations and deaths by an estimated 12-15%.2 Despite penicillin’s continued use today
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