Virtual Lab Cell Cycle and Cancer Worksheet

Topics: Mitosis, Cell cycle, Cell division Pages: 7 (929 words) Published: June 30, 2014

Week 2 Virtual Lab Score: 40/40 (100%)

Week 2 Virtual Lab: The Cell Cycle and Cancer
Worksheet

1. In which phase of mitosis do each of the following occur: a. Centromeres split and chromosomes move toward opposite sides of the cell occur during the anaphase. b. Chromatin coils to form visible chromosomes occur in the prophase. c. The nuclear membrane disappears occur in the prophase.

d. Sister chromatids line up in the center of the cell occur in the metaphase.

2. In which phases of mitosis are sister chromatids visible, and attached to each other at the centromere?

During the metaphase of mitosis, sister chromatids are visible and attach to each other at the centromere.

Table 1: Record your data for the number of cells in each stage of the cell cycle observed in normal tissues.

Tissue Type
# Cells in Interphase
# Cells in Prophase
# Cells in
Metaphase
# Cells in Anaphase
# Cells in
Telophase
Lung Tissue
Sample 1
19
1
0
0
0
Lung Tissue
Sample 2
19
0
0
1
0
Stomach Tissue
Sample 1
16
1
1
0
2
Stomach Tissue
Sample 2
18
0
1
0
1
Ovarian Tissue
Sample 1
17
0
1
2
0
Ovarian Tissue
Sample 2
19
0
0
1
0

Table 2: Record your data for the number of cells in each stage of the cell cycle observed in cancerous tissues (in order to get two samples you will need to reset the microscope image).

Tissue Type
# Cells in Interphase
# Cells in Prophase
# Cells in
Metaphase
# Cells in Anaphase
# Cells in
Telophase
Lung Tissue
Sample 1
15
1
3
0
1
Lung Tissue
Sample 2
16
0
2
1
1
Stomach Tissue
Sample 1
14
2
1
1
2
Stomach Tissue
Sample 2
13
2
2
2
1
Ovarian Tissue
Sample 1
11
2
2
3
2
Ovarian Tissue
Sample 2
12

2
1
2
3

Table 3: Use the data in Table 1 to calculate the Mitotic Index (average % cells dividing) for each normal tissue type.

Tissue Type
Avg. % cells at rest
Mitotic Index
Lung - normal
47.5%
2.5%
Stomach - normal
42.5%
7.5%
Ovary - normal
45%
5%

Table 4: Use the data in Table 2 to calculate the average % cells dividing and average % cells at rest in each cancerous tissue type.

Tissue Type
Avg. % cells at rest
Mitotic Index
Lung - cancerous
38.75%
11.25%
Stomach - cancerous
33.75%
16.25%
Ovary - cancerous
28.75%
21.25%

To calculate the Mitotic Index, the # of cells dividing were the # of cells in the prophase, metaphase, anaphase, and telophase.

Questions:

3. What does your data indicate about the rate of cell division in cancerous tissue compared to the rate of cell division in normal tissue? What data did you use to answer this question?

I compared the percentages of each tissue from the Mitotic Index in normal and cancerous tissue. The data indicated the cell division rate in normal tissue was less than, or slower than in cancerous tissue.

4. Which type of cancer is the fastest growing? Explain your answer, using your relevant data.

The data shows that the ovary cancerous tissue is growing the fastest. Cancerous ovary tissue has the highest Mitotic Index (cell division percentage) and less cells resting on average, which means this type of cancer grows faster than the rest of the other cancerous tissues.

5. With what you have observed in this lab, if you were to compare tissue sample from normal breast tissue and cancerous breast tissue:

a. Would you expect to see a difference in the rate of cell division in the cancerous breast tissue compared to the normal breast tissue? Explain your answer.

Yes, there would be a comparable difference in the cell division rate, due to the fact cancerous tissues divide faster than normal tissue does.

b. Could you make a prediction about the average % dividing cells in the cancerous breast tissue? Explain your answer....
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