Topics: Tricyclic antidepressant, Antidepressant, Imipramine Pages: 4 (1391 words) Published: October 21, 2014

Imipramine belongs to a group of medicines called tricyclic antidepressants.  It affects chemicals in the brain that may become unbalanced. It is generally used to treat symptoms of depression. However, it is also used to treat a completely unrelated condition in children, known as nocturnal enuresis (night-time bedwetting). TRADE NAMES :

TofranilAntidepAntipresMicrodepPraminGENERIC NAME : Imipramine hydrochloride ACTION : Antidepressant
Tablets (imipramine hydrochloride)—10, 25, 50 mg;
capsules (imipramine pamoate)—75, 100, 125, 150 mg
Depression: Hospitalized patients: initially, 100–150 mg/day PO in divided doses. Gradually increase to 200 mg/day as required. If no response after 2 wk, increase to 250–300 mg/day. Total daily dosage may be given hs. Outpatients: initially, 75 mg/day PO, increasing to 150 mg/day. Dosages > 200 mg/day not recommended. Total daily dosage may be given hs. Maintenance dose is 50–150 mg/day.  Chronic pain: 50–200 mg/day PO. 

Adolescent and geriatric patients
Depression: 30–40 mg/day PO; doses > 100 mg/day generally are not needed.  Pediatric patients ≥ 6 yr
Childhood enuresis: Initially, 25 mg/day 1 hr before bedtime. If response is not satisfactory after 1 wk, increase to 50 mg nightly in children < 12 yr, 75 mg nightly in children > 12 yr. Doses > 75 mg/day do not have greater efficacy but are more likely to increase side effects. Do not exceed 2.5 mg/kg per day.

Early-night bedwetters may be more effectively treated with earlier and divided dosage (25 mg midafternoon, repeated hs). Institute drug-free period after successful therapy, gradually tapering dosage. MECHANISM OF ACTION:

Mechanism of action unknown. The TCAs are structurally related to the phenothiazine antipsychotic drugs (eg, chlorpromazine), but unlike the phenothiazines, TCAs inhibit the presynaptic reuptake of the neurotransmitters norepinephrine and serotonin; anticholinergic...
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