Cell Respiration Quiz

Topics: Oxidative phosphorylation, Adenosine triphosphate, Cellular respiration Pages: 3 (936 words) Published: February 22, 2014
The drug “dinitrophenol” (DNP) was prescribed by some physicians in the 1940’s to help patients lose weight. This unsafe method was abandoned after a few patients died. DNP uncouples the chemiosmotic machinery by making the lipid bilayer of the inner mitochondrial membrane leaky to H+. Explain how this could cause weight loss.

In chemiosmosis, NADH are passed along the electron transport chain, with energy used to pump protons across the inner mitochondrial membrane. As the protons are transferred across, a proton gradient is created. These protons can come back across the membrane with the help of the enzyme ATP synthase, thereby producing energy (ATP). If the membrane becomes leaky because of DNP, hydrogen ions would not be routed through ATP synthase to create energy (ATP) because the hydrogen ions would be leaking back across the inner mitochondrial membrane. If ATP were not created, there would be no net energy gain, which could result in weight loss. The drug “dinitrophenol” (DNP) was prescribed by some physicians in the 1940’s to help patients lose weight. This unsafe method was abandoned after a few patients died. DNP uncouples the chemiosmotic machinery by making the lipid bilayer of the inner mitochondrial membrane leaky to H+. Explain how this could cause weight loss.

In chemiosmosis, NADH are passed along the electron transport chain, with energy used to pump protons across the inner mitochondrial membrane. As the protons are transferred across, a proton gradient is created. These protons can come back across the membrane with the help of the enzyme ATP synthase, thereby producing energy (ATP). If the membrane becomes leaky because of DNP, hydrogen ions would not be routed through ATP synthase to create energy (ATP) because the hydrogen ions would be leaking back across the inner mitochondrial membrane. If ATP were not created, there would be no net energy gain, which could result in weight loss. The drug “dinitrophenol” (DNP) was...
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