A Journal Critique on the Synthesis of New Derivatives of Resveratrol and to Explore its Potential Health Benefits

Better Essays
A Journal Critique on the Synthesis of New Derivatives of Resveratrol and to Explore its Potential Health Benefits
Summary
The goal of the study is to extract and purify resveratrol from fresh skin of black grapevine. Resveratrol is a member of a group of plant compounds called polyphenols and belongs to the class called stilbene. Resveratrol is produced by grapes and some plants in response to stress, injury, fungal or bacterial attack and ultraviolet radiation. Studies show that it makes chemotherapy more effective, weaken viruses including influenza and HIV (Adams, 2011). It could also counter the effects of a high-fat diet and increase physical endurance, which some scientists believes that it is one of the factors behind the French Paradox or the concept that despite of the high intake of dietary cholesterol and saturated fat, there is a low percentage of coronary heart disease mortality in France (Ferrières, 2004). In rodent studies, a mice fed with a high-calorie diet lived longer than similarly fed mice not given resveratrol. Resveratrol protected mice fed a high-calorie diet from obesity-related health problems by imitating the effects of caloric restriction (Maddox, 2012). Resveratrol also incredibly lengthen the lifespan of worms, yeast, and some fishes (Adams, 2011). In the experiment, local black grapes were gathered and were classified as Vitis vinifera. The skin was separated from the fruit and was placed in dark, cool area. To avoid oxidation of the plant extract, the steps were done away from direct light. The skin was shaken with ethyl acetate and was kept for 72 hours and was filtered. The filtrate was dried using a rotary evaporator to get one-tenth of its original amount. The functional and phenolic groups present in the resveratrol were tested using standard methods. Aromaticity and the melting point were also determined. In the preparation of the resveratrol derivatives, the first two resveratrol extracts were dissolved in dry benzene. To



References: Adams, M. (2011). Amazing food fact: Miracle nutrient resveratrol is synthesized by grapes in response to fungal attacks. Retrieved February 18, 2013, from Natural News: http://www.naturalnews.com/033905_resveratrol_grapes.html Bertelli AA, et al. (1995). Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4 ',5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats. Retrieved February 27, 2013, from Europe PubMed Central: http://www.europepmc.org/abstract/MED/9063768 Bertelli AA, et al. (1996). Antiplatelet activity of synthetic and natural resveratrol in red wine. Retrieved February 27, 2013, from Europe PubMed Central: http://www.europepmc.org/abstract/MED/7499059 Ferrières, J. (2004). The French paradox: lessons for other countries. Retrieved February 18, 2013, from NCBI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1768013/ Lu, R. & Serrero, G. (1999). Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. Retrieved February 27, 2013, from Wiley Online Library: http://www.onlinelibrary.wiley.com/doi/10.1002/(SICI)1097-4652(199906)179:3%3C297::AID-JCP7%3E3.0.CO;2-P/abstract Maddox, T. (2012). Resveratrol Supplements. Retrieved February 18, 2013, from WebMD: http://www.webmd.com/heart-disease/resveratrol-supplements

You May Also Find These Documents Helpful

  • Better Essays

    Polyphenol Resveratrol

    • 2609 Words
    • 11 Pages

    Thomas D Extended Research Task “The health benefits of red wine have come to light in recent years. Hope is on the horizon, and it may be in your glass!” Despite a seemingly indulgent high saturated fat diet, the French have a substantially lower death rate from coronary disease than any other major country. This phenomenon had been named the French Paradox and it is suggested that their consumption red wine may account for this strange occurrence (Mark Gould, 12/03/2006). In recent years…

    • 2609 Words
    • 11 Pages
    Better Essays
  • Better Essays

    journal critique

    • 1052 Words
    • 5 Pages

    Journal Article Critique I. INTRODUCTION This journal article studies about the “Asian and Euro-American parents’ ethnotheories of play and learning: Effects on preschool children’s home routines and school behaviour.” It was written by Parminder Parmar, Sara Harkness, and Charles M. Super; Pamar is from the Pennsylvania State University, and the other two researchers came from the University of Conneticut, both universities can be found in the USA. The article is studying and discussing about…

    • 1052 Words
    • 5 Pages
    Better Essays
  • Good Essays

    Journal Critique

    • 742 Words
    • 3 Pages

    JOURNAL ARTICLE CRITIQUE of Terry, Justyn. “The Forgiveness of Sins and the Work of Christ: A Case for Substitutionary Atonement.” Anglican Theological Review 95.1 (Winter 2013): 9-24. THEO 510 LUO (Summer 2013) Survey of Theology Liberty Baptist Theological Seminary Joshua M. Peoples (ID# 22750743) May 26, 2013 A Journal Critique of “The Forgiveness of Sins and the Work of Christ: A Case for Substitutionary Atonement.”…

    • 742 Words
    • 3 Pages
    Good Essays
  • Powerful Essays

    Journal Critique

    • 1304 Words
    • 6 Pages

    Journal Paper Critique STUDY OF GEOTHERMAL POWER PLANT ELECTRICAL AND CONTROL SYSTEM WITH EMPHASIS ON RELIABILITY ASPECTS In Partial Fulfillment of the Requirements for the Subject Electrical Control System Submitted By: Stephen R. Chua BSEE5A Bulacan State University Submitted to: Engr. Erwin Magsakay Professor July 03, 2012 GEOTHERMAL TRAINING PROGRAMME Reports 2002 Orkustofnun, Grensásvegur 9, Number 7 IS-108 Reykjavík, Iceland STUDY OF GEOTHERMAL POWER PLANT ELECTRICAL AND…

    • 1304 Words
    • 6 Pages
    Powerful Essays
  • Powerful Essays

    Journal Article Critique

    • 1126 Words
    • 5 Pages

    Journal Article Critique Student’s Name Institution Affiliation Journal Article Critique The need to adopt and adapt to the ever-changing modern world coupled by the desire to improve productivity and efficiency means that new insights and effective ways of carrying out operations is a welcome reprieve in all professions. An important way through which individuals can identify fresh and effective perspectives and approaches that can foster organizational and profession efficiency and productivity…

    • 1126 Words
    • 5 Pages
    Powerful Essays
  • Good Essays

    Anti-Aging and the Benefits of Resveratrol in Red Wine Brandon Tietz SOC 400 Mitch Aagard Stevens-Henager College Anti-Aging and the Benefits of Resveratrol in Red Wine In a study carried out by Harvard professor, Dr. David Sinclair, he tested the effects of the compound Resveratrol in mice, a compound found in red wine. He “argued that the phytonutrient worked its magic by ‘turning on’ the SIRT1 gene, one of a family of genes called the Sirtuins.” (Healy, 2012). It is believed to control…

    • 619 Words
    • 3 Pages
    Good Essays
  • Powerful Essays

    Journal Article Critique

    • 1350 Words
    • 6 Pages

    Critique of Journal article The article being critiqued is titled; Randomised controlled trial of motivational interviewing compared with drug information and advice for early intervention among young cannabis users written by Jim McCambridge, Renee L Slym and John Strang published in 2008 in the journal Addiction, pages 103-111. Cannabis is the most widely used illegal drug and poses many physical, social and psychological risks especially in young people, it seems that even with the current primary…

    • 1350 Words
    • 6 Pages
    Powerful Essays
  • Powerful Essays

    Interior Journal Critique

    • 1150 Words
    • 5 Pages

    TORRES, MARIE ANGELINE V. 21D-1 Journal Critique 1 Understanding Controls, Behaviors and Satisfaction in the Daylit Perimeter Office: A Daylight Design Case Study Julia Day, M.A., Judy Theodorson, and Kevin Van Den Wymelenberg The literature and findings of this case study suggest that there is still much to know about how people use daylit environments. These results also suggest that interior designers must become more aware of the consequences related to the introduction of day lighting…

    • 1150 Words
    • 5 Pages
    Powerful Essays
  • Better Essays

    Journal Article Critique

    • 1695 Words
    • 7 Pages

    Journal Article Critique PRESENTED TO THE DEPARMENT OF PHYSICAL EDUCATION AND RECREATION STUDIES MOUNT ROYAL UNIVERSITY In Partial Fulfillment Of the Requirements for Course PHED # 1007 Section # 001 Lynne Lafave By Luis Bravo Vocabulary * Anthropometric Parameters: Different methods established to measure the proportions of the body. * Epigallocatechin Gallate: Powerful antioxidant found in green tea. * Atherosclerosis: Is the accumulation of fatty material in the inner walls of the…

    • 1695 Words
    • 7 Pages
    Better Essays
  • Powerful Essays

    Journal Article Critique

    • 1953 Words
    • 8 Pages

    Research Article 1 Roberts, T. (2003). Effects of Alphabet-Letter Instruction on Young Children's Word Recognition [Electronic Version]. Journal of Educational Psychology, 95 (1), 41-51. Title The title of the article gave a fair representation of the topic as it was clear and concise in the wording. The title encompassed the idea that alphabet letter instruction on young children's word recognition would be explored through experiments and analysis. Reading on through the article it was evident…

    • 1953 Words
    • 8 Pages
    Powerful Essays