Zinc Picolinate Research Paper

Zinc is one of the longest-studied nutrients that correlates with statistically significantly less acne. Some months ago, I discovered that around 200mg/day of zinc picolinate could, under some circumstances, make me dramatically acne-free for the first time ever. That led to a very long course of study, research and experiments.

For a megadose of zinc to affect acne dramatically, a good bet was that zinc is a cofactor in a reaction that affects acne. If you have a chemical reaction in the body like Zinc + X -> Y, then flooding the area with zinc will at least modestly increase the production of Y, since it makes it more likely that all the available "X" will get used up. After much study, I concluded that "Y" is actually zinc superoxide
For example, I have long struggled with the ability to consume legumes. I bought into the standard advice that it's a problem of gut flora, if you eat them long enough your gut will adjust and digest them better without gas, etc. If I had a large Coke and a large burrito, the result was 100% predictable: great intestinal discomfort. However, I now know that was simply another problem of failing to suppress daytime melatonin. By living in outdoor light all day, I can slam down a Coke+burrito with zero intestinal discomfort, hardly any gas at all. I've repeated this experiment reliably several times, and outdoor light exposure is like a light switch (heh!) on my ability to digest legumes. I speculate that the growth in acid reflux disease (and the esophageal cancer it can lead to) is probably another result of living in dim light during the day that produces carbohydrate malabsorption.

The unfortunate thing is, although the pill-free cure for my acne is conceptually very simple, it's also very hard for modern people to accomplish. I had to buy a laptop with an extra-bright screen so I could work outdoors during the day -- most people have indoor jobs with no option of working outdoors. Just look at some the many ways we guarantee we won't have a natural melatonin cycle:
Work indoors all day. Indoor light simply does not produce the definitive OFF signal for pineal melatonin that outdoor light does. Even on a severely overcast
Want to catch that late movie on the weekend? It's just like a form of jetlag -- your body's 24-hour clock just got bumped and may take days to settle back down to match your regular bedtime again.
Take in lots of caffeine. Caffeine will both depress your nocturnal melatonin peak and shorten the hours you sleep, both ways to become melatonin-deprived.
Vegetarianism. Without meat, it becomes more difficult to get enough tryptophan and zinc in the diet. If you combine that with eating high-fructose foods like apples, pears, etc. and living in dim light during the day to produce fructose malabsorption, that greatly raises the odds of acne. This is not to say you can't be a vegetarian and acne-free, but it is plausible that some vegetarians might have to take a couple of pills to get there.
Sunglasses, hats, travel in cars, etc. If you compare modern people to the completely acne-free primitive tribes that still exist, it's almost like we are comically trying to avoid getting any daylight in our eyes. We stay indoors all day. When we travel, we run from shaded building to shaded car (often with dark-tinted windows). We cover our eyes with dark glasses not just when the light is bright, but often just as a fashion statement when the light isn't even bright at