Williams Syndrome Research Paper
Running Head: AMYGDALA & HYPERSOCIABILITY
The Role of the Amygdala and Abnormal Social Behavior in Williams Syndrome
Abstract
Williams syndrome (WS) is a genetic neurodevelopmental disorder often paired with unique behavioral abnormalities like hypersociability, reduced fear and a tendency to approach strangers. The amygdala is an integral component of the neural network and has been implicated in social phenotype particularly in emotion and fear. Functional magnetic resonance imaging (fMRI) and blood-oxygenation-level-dependent (BOLD) responses indicated abnormal structure and function of amygdala in individuals with WS during face processing tasks. In healthy individuals amygdala activity is controlled by dense axonal projections of the prefrontal …show more content…
Research in Developmental Disabilities. 32, 1169-1179
Capitao, L., Sampaio, A., Sampaio, C., Vasconcelos, C., Fernandez, M., Garayzabal, E., Shenton, M. E., and Goncalves, O. F. (2011b) MRI amygdala volume in Williams Syndrome. Research in Developmental Disabilities. 32, 2767–2772
Ghashghaei, H.T., Barbas, H., (2002). Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey. Neuroscience
115, 1261–1279.
Haas, B. W., Hoeft, F., Searcy, Y. M., Mills, D., Bellugi, U., and Reiss, A. (2009a). Individual differences in social behavior predict amygdala response to fearful facial expressions in Williams syndrome. Neuropsychologia 48, 1283–1288.
Haas, B. W., Mills, D., Yam, A., Hoeft, F., Bellugi, U., and Reiss, A. (2009b). Genetic Influences on Sociability: Heightened Amygdala Reactivity and Event-Related Response to Positive Social Stimuli in Williams Syndrome The Journal of Neuroscience 29(4),
The Role of the Amygdala and Abnormal Social Behavior in Williams Syndrome
Abstract
Williams syndrome (WS) is a genetic neurodevelopmental disorder often paired with unique behavioral abnormalities like hypersociability, reduced fear and a tendency to approach strangers. The amygdala is an integral component of the neural network and has been implicated in social phenotype particularly in emotion and fear. Functional magnetic resonance imaging (fMRI) and blood-oxygenation-level-dependent (BOLD) responses indicated abnormal structure and function of amygdala in individuals with WS during face processing tasks. In healthy individuals amygdala activity is controlled by dense axonal projections of the prefrontal …show more content…
Research in Developmental Disabilities. 32, 1169-1179
Capitao, L., Sampaio, A., Sampaio, C., Vasconcelos, C., Fernandez, M., Garayzabal, E., Shenton, M. E., and Goncalves, O. F. (2011b) MRI amygdala volume in Williams Syndrome. Research in Developmental Disabilities. 32, 2767–2772
Ghashghaei, H.T., Barbas, H., (2002). Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey. Neuroscience
115, 1261–1279.
Haas, B. W., Hoeft, F., Searcy, Y. M., Mills, D., Bellugi, U., and Reiss, A. (2009a). Individual differences in social behavior predict amygdala response to fearful facial expressions in Williams syndrome. Neuropsychologia 48, 1283–1288.
Haas, B. W., Mills, D., Yam, A., Hoeft, F., Bellugi, U., and Reiss, A. (2009b). Genetic Influences on Sociability: Heightened Amygdala Reactivity and Event-Related Response to Positive Social Stimuli in Williams Syndrome The Journal of Neuroscience 29(4),