Why Was Lispro Prescribed To Diabetes
. What type of medication is prescribed to diabetics? Insulin.
2. What type of medication is prescribed to diabetics? For human insulin, it is consists of two polypeptide chains in which the chain A has 21 amino acids and chain B has 30 amino acids (Beta Cell Biology Consortium, 2014). Other than that, the two polypeptide chains are connected by two inter-chain disulfide bridges (Beta Cell Biology Consortium, 2014). For insulin from other animals, the structure is almost the same as human insulin, the only difference is the sequence of amino acids (Walsh, 2007).
3. Why was Lispro prescribed to the patient immediately? Lispro is a man-made version of human insulin. Lispro can be prescribed to the patient immediately for immediate treatment of …show more content…
Describe the structure of Lispro. The structure of Lispro is engineered through the utilization of recombinant DNA technology, where the C-terminal end of the B-chain which contains the proline and penultimate lysine residues are reversed. Although modifications were done, receptor bind were not altered. However, this modification does alter the formation of insulin dimmers and hexamers. This modification does not alter receptor binding, but blocks the formation of insulin dimers and hexamers and this resulted in considerably larger amounts of active monomeric insulin to be available immediately for postprandial injections. (Sara, Pharm, Elizabeth & Bill, …show more content…
Describe the structure of the drug and how it differs from Lispro. Novolog is one of the modified form of insulin which its structure almost the same as insulin, which contains 2 polypeptide chains with 2 disulfide bridges (Beta Cell Biology Consortium, 2014). Novolog is modified to consist an aspartic acid instead of a proline at position 38 of normal insulin B-chain (Beta Cell Biology Consortium, 2014).
Molecular formula of Novolog is C₂₅₆H₃₈₇N₆₅O₇₉S₆ (PubChem Open Chemistry Database, 2012) whereas molecular formula of Lispro is C₂₅₇H₃₈₉N₆₅O₇₇S₆ (PubChem Open Chemistry Database, 2012). Novolog has aspartic acid at position 38 of its B-chain whereas Lispro has lysine at position 28 and proline at 29 of its B-chain (PubChem Open Chemistry Database,
2. What type of medication is prescribed to diabetics? For human insulin, it is consists of two polypeptide chains in which the chain A has 21 amino acids and chain B has 30 amino acids (Beta Cell Biology Consortium, 2014). Other than that, the two polypeptide chains are connected by two inter-chain disulfide bridges (Beta Cell Biology Consortium, 2014). For insulin from other animals, the structure is almost the same as human insulin, the only difference is the sequence of amino acids (Walsh, 2007).
3. Why was Lispro prescribed to the patient immediately? Lispro is a man-made version of human insulin. Lispro can be prescribed to the patient immediately for immediate treatment of …show more content…
Describe the structure of Lispro. The structure of Lispro is engineered through the utilization of recombinant DNA technology, where the C-terminal end of the B-chain which contains the proline and penultimate lysine residues are reversed. Although modifications were done, receptor bind were not altered. However, this modification does alter the formation of insulin dimmers and hexamers. This modification does not alter receptor binding, but blocks the formation of insulin dimers and hexamers and this resulted in considerably larger amounts of active monomeric insulin to be available immediately for postprandial injections. (Sara, Pharm, Elizabeth & Bill, …show more content…
Describe the structure of the drug and how it differs from Lispro. Novolog is one of the modified form of insulin which its structure almost the same as insulin, which contains 2 polypeptide chains with 2 disulfide bridges (Beta Cell Biology Consortium, 2014). Novolog is modified to consist an aspartic acid instead of a proline at position 38 of normal insulin B-chain (Beta Cell Biology Consortium, 2014).
Molecular formula of Novolog is C₂₅₆H₃₈₇N₆₅O₇₉S₆ (PubChem Open Chemistry Database, 2012) whereas molecular formula of Lispro is C₂₅₇H₃₈₉N₆₅O₇₇S₆ (PubChem Open Chemistry Database, 2012). Novolog has aspartic acid at position 38 of its B-chain whereas Lispro has lysine at position 28 and proline at 29 of its B-chain (PubChem Open Chemistry Database,