Why Is Saferstein Important
CM8002 Drugs
Saferstein Chapter 8
Drugs
Natural
Used since ancient times, mostly by “medicine men”
Semi-synthetic
Modified natural compounds
Synthetic
Misuse of pharmaceutical results
Abuse of solvents
Physical and Psychological addiction www.cnb.gov.sg www.dea.gov
Drugs
“The fly agarics are dried and eaten in large pieces. After about half an hour, the person becomes completely intoxicated and experiences extraordinary visions.
CO2H
O
Those who cannot afford the high
N
NH2 price of the mushrooms drink the urine of those who have eaten,
HO
whereupon they become
Ibotenic acid - interferes intoxicated, if not more so” with neurotransmitters in the brain
Georg Steller in Siberia, 1774
Peyote and …show more content…
Saferstein page 207-208
Opium in art and medicine
Also used for gastrointestinal problems Samuel Taylor Coleridge:
“Xanadu”
"This fragment with a good deal more, not recoverable, composed, in a sort of Revery brought on by two grains of Opium taken to check a dysentry, at a Farm House between
Porlock and Linton, a quarter of a mile from
Culbone Church, in the fall of the year, 1797."
Opium in Art, War and Politics
Opium wars
1839-1842 and
1856-1860
Hector Berlioz:
Symphonie Fantastique
the 4th movement on U-tube
Herman Goering: morphine addict and head of the German airforce in WW2
Opium, Morphine and Heroin
Heroin was invented by the Bayer Co. It was diacetylmorphine - more potent than morphine.
Harold Shipman
215 victims?
May still be legally prescribed in the UK
Heroin - faster transport to the brain
H3C
HO
O
O
N
HO
Morphine
H3C
O
O
O
O
O
CH3
O
N
CH3
CH3 Acetic anhydride - H C
O
3 controlled in many
Diacetylmorphine
Asian countries or diamorphine
The term “heroin” now refers to the illegal drug …show more content…
Numerous fatalities.
Saferstein page 211
Amphetamines
CH3
NH2
CH3
HN
CH3
O
O
NH2
CH3
O
O
CH3
HN
Synthetic compounds. Method of making (synthesis) leaves characteristic impurities. Precursor chemicals are controlled. CH3
Saferstein page 213
Amphetamines
Smuggling of precursor chemicals is big business
US$207,000,000 seized in March 2007 by the US DEA www.usdoj.gov/dea/multimedia.html Amphetamines - natural relatives
O
CH3
NH2
cathinone
Qat - widely chewed in the Horn of
Africa and the Middle East, especially Yemen
ketamine
O
NHCH3
Cl
Originally an anaesthetic; now veterinary use only
Typically stolen
Hallucinogen
Affects memory, sensation, mood
Delirium, amnesia, depression
Has been used for date-rape
Solid or liquid
Ingested, smoked, injected
Saferstein page 215
Drugs
Analogs “Krokodil”
CH3
HO
O iodine red phosphorus hydrochloric acid gasoline or oil
O
N
HO
Saferstein Chapter 8
Drugs
Natural
Used since ancient times, mostly by “medicine men”
Semi-synthetic
Modified natural compounds
Synthetic
Misuse of pharmaceutical results
Abuse of solvents
Physical and Psychological addiction www.cnb.gov.sg www.dea.gov
Drugs
“The fly agarics are dried and eaten in large pieces. After about half an hour, the person becomes completely intoxicated and experiences extraordinary visions.
CO2H
O
Those who cannot afford the high
N
NH2 price of the mushrooms drink the urine of those who have eaten,
HO
whereupon they become
Ibotenic acid - interferes intoxicated, if not more so” with neurotransmitters in the brain
Georg Steller in Siberia, 1774
Peyote and …show more content…
Saferstein page 207-208
Opium in art and medicine
Also used for gastrointestinal problems Samuel Taylor Coleridge:
“Xanadu”
"This fragment with a good deal more, not recoverable, composed, in a sort of Revery brought on by two grains of Opium taken to check a dysentry, at a Farm House between
Porlock and Linton, a quarter of a mile from
Culbone Church, in the fall of the year, 1797."
Opium in Art, War and Politics
Opium wars
1839-1842 and
1856-1860
Hector Berlioz:
Symphonie Fantastique
the 4th movement on U-tube
Herman Goering: morphine addict and head of the German airforce in WW2
Opium, Morphine and Heroin
Heroin was invented by the Bayer Co. It was diacetylmorphine - more potent than morphine.
Harold Shipman
215 victims?
May still be legally prescribed in the UK
Heroin - faster transport to the brain
H3C
HO
O
O
N
HO
Morphine
H3C
O
O
O
O
O
CH3
O
N
CH3
CH3 Acetic anhydride - H C
O
3 controlled in many
Diacetylmorphine
Asian countries or diamorphine
The term “heroin” now refers to the illegal drug …show more content…
Numerous fatalities.
Saferstein page 211
Amphetamines
CH3
NH2
CH3
HN
CH3
O
O
NH2
CH3
O
O
CH3
HN
Synthetic compounds. Method of making (synthesis) leaves characteristic impurities. Precursor chemicals are controlled. CH3
Saferstein page 213
Amphetamines
Smuggling of precursor chemicals is big business
US$207,000,000 seized in March 2007 by the US DEA www.usdoj.gov/dea/multimedia.html Amphetamines - natural relatives
O
CH3
NH2
cathinone
Qat - widely chewed in the Horn of
Africa and the Middle East, especially Yemen
ketamine
O
NHCH3
Cl
Originally an anaesthetic; now veterinary use only
Typically stolen
Hallucinogen
Affects memory, sensation, mood
Delirium, amnesia, depression
Has been used for date-rape
Solid or liquid
Ingested, smoked, injected
Saferstein page 215
Drugs
Analogs “Krokodil”
CH3
HO
O iodine red phosphorus hydrochloric acid gasoline or oil
O
N
HO