Vitamin B12 Lab Report

A STUDY OF CORRELATION BETWEEN VITAMIN B12 DEFICIENCY AND CLINICAL, HAEMATOLOGICAL AND ELECTROPHYSIOLOGICAL PARAMETERS OF VITAMIN B12 DEFICIENCY
Dr. Chetan Anil Bhole1, Dr. Tarun Kumar Ralot2*, Dr. R L Meena3, Dr. Neera Samar4, Dr. Vignesh S.5 ,Dr. Chander Bafna6
1,5,6. Resident, Department of Medicine, RNT Medical college ,Udaipur
2. Assistant Professor, Department of Neurology, RNT Medical college
3. Professor, Department of Medicine, RNT Medical college ,Udaipur
4. Associate Professor, Department of Medicine, RNT Medical college ,Udaipur

*Email id of corresponding author- [e-mail]
Received: 30/01/2015 Revised: 16/04/2015 Accepted: 22/04/2015
ABSTRACT:
Objectives: Vitamin B12 is an essential micronutrient essential for appropriate
In type 1 and type 2 diabetes mellitus cases, Biochemical and clinical vitamin B12 deficiency has been demonstrated & highly prevalent. It presents with various clinical manifestations which ranging from megaloblastic anaemia, pancytopenia, impaired memory, delirium, dementia, peripheral neuropathy, and sub acute combined degeneration of the spinal cord.
Deficiency of vitamin B12 is not very uncommon because the human body can store vitamin B12 to last for up to five years. The commonly use investigation are Low serum vitamin B12 level or megaloblastic bone marrow or both which are basis of diagnosis of deficiency of vitamin B12 (1, 2). There has been much debate over establishing a universally accepted normal range for vitamin B12 and till date prevalence of B12 deficiency in the general population. (3,4). Vitamin B12, apart from causing neuropsychiatric symptoms, leads to hyperhomocysteinemia and methylmalonic acidemia which can have serious health implications. Low serum vitamin B12 levels have low sensitivity and specificity in terms of tissue deficiency (5). Homocysteine and methylmalonic acid estimations are adjunct and aid in diagnosis of B12 deficiency but still serum vitamin B12 measurement is the extensively applied standard method by practical
However, no such data are available in elderly Indian population. With increasing ageing population, varied socio-economic strata and high prevalence of Helicobacter pylori infection along with vegetarian diet followed in majority of Indian households, the prevalence of vitamin B12 and folate deficiency may be much higher in Indian population. There are two studies so far in India showing prevalence of vitamin B12 and folate deficiency. One study conducted by Yagnik et al, investigated the prevalence of low vitamin B12 concentration and hyperhomocysteinemia in rural and urban Indian men living in and around Pune, Maharastra (8). The analysis showed vitamin B12 level of 150 pmol/l in 67 per cent of men and hyperhomocysteinemia (100fl 49 63 112