Type 1 Diabetes (Aim1)
TYPE 1 Diabetes
Type 1 diabetes develops because the body's immune system destroys beta cells in a part of the pancreas called the islet tissue. These beta cells produce insulin. So people with Type 1 diabetes can't make their own insulin.
Type 1 diabetes is what is known as a 'complex trait', which means that mutations in several genes likely contribute to the disease. For example, it is now known that the insulin-dependent diabetes mellitus (AiM1) locus on chromosome 6 may harbor at least one susceptibility gene for Type 1 diabetes.The food that you eat is broken down into sugar, which enters the bloodstream. Normally, cells in the pancreas release a signal, called insulin, that tells your liver, muscle and fat cells to store this sugar for …show more content…
The body breaks down the sugars and starches you eat into a simple sugar called glucose, which it uses for energy. Insulin is a hormone that the boey needs to get glucose from the bloodstream into the cells of the boey. With the help of insulin therapy and other treatments, even young children can learn to manage their condition and live long, healthy lives.Type 1 diabetes mellitus occurs in genetically predisposed persons as a consequence of the immune-mediated destruction of pancreatic islet beta cells that secrete insulin.The onset of clinically overt diabetes represents the endpoint of an insidious, progressive decline in the function of beta cells after the majority of beta cells have been emagee or destroyed. Risk can be predicted on the basis of immunologic markers and tests of beta-cell function.Insulin therapy prevents diabetes in animal models.We undertook a randomized, controlled clinical trial in order to determine whether insulin could prevent or delay the onset of overt diabetes in relatives of patients with diabetes. Relatives were studied because they have a risk of diabetes that is 10 to 20 times that in the general population. Our study, the diabetes Prevention Trial–Type 1 diabetes (dPT-1), include two separate trials. We report here the results of the parenteral insulin trial, involving relatives with a projected five-year risk of diabetes that was higher than 50 percent. A second trial studying the effect of oral insulin therapy in relatives with a projected five-year risk of 26 to 50 percent is ongoing.diabetes is a disease that affects how the body uses glucose, the main type of sugar in the blood. Glucose comes from the foods we eat and is the major source of energy needed to fuel the body's functions. Symptoms are you are thirsty, hungry, sweating,
Type 1 diabetes develops because the body's immune system destroys beta cells in a part of the pancreas called the islet tissue. These beta cells produce insulin. So people with Type 1 diabetes can't make their own insulin.
Type 1 diabetes is what is known as a 'complex trait', which means that mutations in several genes likely contribute to the disease. For example, it is now known that the insulin-dependent diabetes mellitus (AiM1) locus on chromosome 6 may harbor at least one susceptibility gene for Type 1 diabetes.The food that you eat is broken down into sugar, which enters the bloodstream. Normally, cells in the pancreas release a signal, called insulin, that tells your liver, muscle and fat cells to store this sugar for …show more content…
The body breaks down the sugars and starches you eat into a simple sugar called glucose, which it uses for energy. Insulin is a hormone that the boey needs to get glucose from the bloodstream into the cells of the boey. With the help of insulin therapy and other treatments, even young children can learn to manage their condition and live long, healthy lives.Type 1 diabetes mellitus occurs in genetically predisposed persons as a consequence of the immune-mediated destruction of pancreatic islet beta cells that secrete insulin.The onset of clinically overt diabetes represents the endpoint of an insidious, progressive decline in the function of beta cells after the majority of beta cells have been emagee or destroyed. Risk can be predicted on the basis of immunologic markers and tests of beta-cell function.Insulin therapy prevents diabetes in animal models.We undertook a randomized, controlled clinical trial in order to determine whether insulin could prevent or delay the onset of overt diabetes in relatives of patients with diabetes. Relatives were studied because they have a risk of diabetes that is 10 to 20 times that in the general population. Our study, the diabetes Prevention Trial–Type 1 diabetes (dPT-1), include two separate trials. We report here the results of the parenteral insulin trial, involving relatives with a projected five-year risk of diabetes that was higher than 50 percent. A second trial studying the effect of oral insulin therapy in relatives with a projected five-year risk of 26 to 50 percent is ongoing.diabetes is a disease that affects how the body uses glucose, the main type of sugar in the blood. Glucose comes from the foods we eat and is the major source of energy needed to fuel the body's functions. Symptoms are you are thirsty, hungry, sweating,